Tsoom Fwv Asmeskas FDA Pom Zoo Muab Kev Sib Koom Tes Thib Ob Thib Tus Kheej Tus Neeg Tshaj Lij ABI-H2158 Kev Nrauj Qho Tsis Tau!

Lub Rooj Sib Tham Biosciences yog lub chaw tsim kho mob biotechnology soj ntsuam txog kev tsim kho tshiab rau kev kho tus kab mob siab hom B (HBV) thiab kab mob ntsig txog microbiota. Tsis ntev los no, lub tuam txhab tshaj tawm tias Asmeskas Chaw Tswj Khoom Noj thiab Tshuaj Yeeb Tshuaj (FDA) tau tso cai rau ABI-H2158 Kev Tawm Tshav Tawm Ceev (FTD), uas yog lub sijhawm thib ob cov tub ntxhais hluas protein inhibitor (CI) ntawm Lub Rooj Sib Tham, thiab tam sim no nyob rau hauv lub ntiaj teb theem II. Kev soj ntsuam hauv kev soj ntsuam kuaj mob.

Nws tsim nyog teev tias ua ntej, lub tuam txhab' s thawj-tiam tub ntxhais protein inhibitor ABI-H0731 tseem tau tso cai FTD los ntawm FDA, thiab cov tshuaj tam sim no nyob rau theem II kev txhim kho chaw kho mob.

Kev khiav ceev ceev (FTD) lub hom phiaj ua kom nrawm nrawm txhim kho thiab tshuaj xyuas sai sai ntawm cov tshuaj rau cov kab mob loj los daws cov kev kho mob tsis txaus ntseeg nyob hauv thaj chaw tseem ceeb. Tau txais cov txuj ci nrawm rau tshuaj tshawb nrhiav txhais tau tias cov tuam txhab tshuaj tuaj yeem cuam tshuam nrog FDA ntau dua thaum lub sijhawm tshawb fawb thiab kev txhim kho. Tom qab xa cov ntawv thov kev lag luam, yog tias lawv ua tau raws cov qauv tsim nyog, lawv tsim nyog rau kev pom zoo nrawm thiab kev tshuaj xyuas ua ntej. Ntxiv rau, lawv kuj tsim nyog rau cov ntawv thov dov. Cov.

Luisa Stamm, Tus Thawj Saib Xyuas Kev Kho Mob ntawm Assembly Biosciences, hais tias: "Peb zoo siab tias peb cov tub ntxhais hluas thib ob txwv tsis pub muaj tus kabmob ABI-H2158 tau tso cai sai ntawm FDA rau kev kho kab mob siab B mob ntev. Kab mob siab hom B cuam tshuam rau lub ntiaj teb 2,5 100 lab tus tib neeg thiab ntau dua 1 lab tus neeg nyob hauv Tebchaws Meskas muaj tus mob. FTD qhov kev tsim nyog tuaj yeem muab ntau qhov zoo tseem ceeb, uas tuaj yeem ua kom nrawm nrawm txhim kho thiab tswj xyuas ABI-H2158, thiab hais txog qhov tseem ceeb ntawm kev muab cov tshuaj tshiab rau cov neeg mob."

Tam sim no, nucleoside (acid) analog transcriptase inhibitor (NRTI) yog cov tshuaj tu mob rau HBV. Cov tshuaj muaj kev nyab xeeb, zoo tiv thaiv, muaj tshuaj tiv thaiv qis, thiab tuaj yeem txo HBV DNA. Txawm li cas los xij, cov tshuaj no tsis tuaj yeem tshem tawm tus kabmob, tsis tuaj yeem tiv thaiv kev tsim ntawm cccDNA tshiab, thiab yuav tsum tau kho mus ib txhis. Thiab yog tias tus kab mob uas tseem tshuav tsis tau muab tua pov tseg, tsis muaj kev kho kom zoo.

Cov tub ntxhais hluas protein inhibitor (CI) tuaj yeem tiv thaiv ntau kauj ruam ntawm tus kabmob hloov mus los, ua tiav qib siab / sib sib zog nqus ntawm cov kabmob inhibition piv nrog NRTI, thiab tuaj yeem tiv thaiv kev tsim ntawm cccDNA.

Tam sim no, Los ua ke tab tom tsim ntau yam ntawm CI, lub hom phiaj ntawm qhov kawg yog siv cov tshuaj sib xyaw ua ke kom tiav qhov kev tiv thaiv kab mob thiab kis tus kab mob, thiab txhim kho tus nqi kho mob nrog tsawg lub sijhawm kho mob.

Kev sib dhos HBV cov cuab tam muaj xws li peb qhov chaw kuaj mob-theem me me cov tshuaj molecule, tag nrho cov no yog HBV tiv thaiv kab mob, tsom mus rau ntau theem ntawm HBV lub neej. Hauv theem II cov kev sim tshuaj, thawj-lub cim tseem ceeb inhibitor ABI-H0731 ua ke nrog NRTI tau pom zoo zoo. Piv nrog NrtI kev kho mob ib leeg, nws tau qhia ntau dua kev ua haujlwm tiv thaiv kab mob siab rau HBV DNA, thiab Qhia kom txo qis HBV pregenomic RNA (pgRNA), uas qhia tau tias HBV cccDNA qib qis hauv lub siab.

Cov khoom sib dhos' s HBV cov cuab tam rau cov kav dej sib txuas kuj muaj ob qhov muaj zog, qhov thib ob tsim cov khoom sib tw, ABI-H2158 yog nyob rau theem II kev kuaj mob, thiab ABI-H3733 yog nyob rau theem I kev txhim kho.