TAK-438, Vonoprazan Fumarate CAS 1260141-27-2

Khoom Qhia:

Cov Khoom Npe: TAK-438 Vonoprazan fumarate CAS TSIS: 1260141-27-2

Txhais:

1- [5- (2-Fluorophenyl) -1- (3-pyridinylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamine (2E) -2-butenedioate (1: 1);

1- (5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl) -N-methylmethanamine fumarate;

1- [5- (2-fluorophenyl) -1-pyridin-3-ylsulfonylpyrrol-3-yl] -N-methylmethanamine, (E) -4-oxopent-2-enoic acid;

5- (2-Fluorophenyl) -N-methyl-1- (3-pyridinylsulfonyl) -1H-pyrrole-3-methanamine (2E) -2-butenedioate;

Tshuaj& Cov Khoom Uas Lub Cev:

Zog: hmoov.

Ntsuas: ≥99.0%

Soluble: DMSO> 10 hli

CAS Lwm Yam #: Dawb Puag: 881681-00-1

Tak-438 (vonoprazan fumarate) yog qhov ncauj tawm tshiab tiv thaiv lub plab acid acid tsim los ntawm Takeda kws tshuaj thiab Otsuka kws.

[rau npe kev faib tawm] tshuaj kho mob 3.1

[kev ntsuas] rau kev kho mob ntawm txoj hlab pas leeg, mob plab thiab mob hnyuv duodenal. Thaum Lub Ob Hlis 28, 2014, Takeda kws tshuaj tau xa daim ntawv thov tshuaj tshiab (NDA) ntawm vonoprazan (tak-438) rau Ministry of Labor, Health thiab welfare ntawm Nyij Pooj (MHLW). Kev xa ntawm daim ntawv thov cov tshuaj tshiab tshiab yog ua raws li cov ntaub ntawv zoo ntawm theem III kev sim tshuaj. Takeda kws tshuaj tau ua tiav ntau theem III kev soj ntsuam hauv tebchaws Nyij Pooj los tshawb xyuas qhov ua tau zoo ntawm tak-438 hauv kev kho mob ntawm txoj hlab pas, mob plab, mob plab, duodenal mob thiab Helicobacter pylori. Hauv kev sim kho mob, piv nrog cov PPI tam sim no, cov khoom siv tshuaj ntsuab သတိပေး ceeb toom razan (tak-438) tsis muaj CYP2C19 metabolism, yog li nws pom tias kev ua tau zoo dua hauv kev sim kho mob: nws zoo dua li lansoprazole hauv kev kho mob plab hnyuv / duodenal mob plab, tsis kam rov qab. txoj hlab pas, txoj hauv kev tshem tawm Helicobacter pylori, thiab muaj kev tiv thaiv zoo thiab kev nyab xeeb. Thaum Lub Kaum Ob Hlis 26, 2014, tak-438 (vonoprazanfumarate) tau pom zoo rau kev lag luam hauv Nyij Pooj (npe lag luam: takecab) rau kev kho mob ntawm cov kua qaub ntsig txog cov kab mob. Piv nrog rau cov tsoos tsis tuaj yeem tiv thaiv cov twj tso kua mis inhibitors (xws li omeprazole, esomeprazole, thiab lwm yam), takecab muaj cov txiaj ntsig zoo li hauv qab no: ① pib sai, thawj hnub ntawm kev tswj hwm yuav ua tiav qhov siab tshaj plaws acid inhibition effect; Administration tswj hwm qhov ncauj, tsis muaj kev cuam tshuam los ntawm kev mob plab zom mov, tsis tas yuav tsum tau ua kev daws teeb meem ③ txhawm rau txhim kho hmo ntuj acid breakthrough phenomenon.

Daim ntaub ntawv: Vonoprazan Fumarate yog qhov tshiab potassium-sib tw acid blocker rau kev kho mob ntawm cov kab mob acid.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: tak-438, vonoprazan fumarate cas 1260141-27-2, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

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