Roche thiab NeuExcell tau mus txog qhov kev koom tes zoo los tsim cov kev kho tshiab siv Cov Nerve Regeneration Gene Therapy Platform!

Roche' lub tuam txhab kho noob caj ces Spark Therapeutics thiab NeuExcell Therapeutics tau mus txog kev sib koom tes kho noob los tsim kho kev nyab xeeb thiab zoo rau Huntington' tus kab mob (HD) cov neeg mob.

HD yog ib qho kab mob hauv lub hlwb uas kho tsis tau uas tshwm sim los ntawm cov noob tsis zoo ntawm chromosome 4. Vim tias tus kab mob cuam tshuam rau ntau qhov chaw ntawm lub hlwb, nws cuam tshuam rau kev txav, kev coj cwj pwm, thiab kev paub. Nws nyuaj zuj zus rau cov neeg mob taug kev, xav, xav, nqos, thiab hais lus. Thaum kawg, yuav tsum muaj kev saib xyuas puv sij hawm. Cov teeb meem cuam tshuam nrog HD feem ntau ua rau tuag taus.

Raws li cov lus pom zoo, Spark Therapeutics yuav tau txais NeuExcell' cov tswv cuab ntawm cov paj hlwb regeneration gene therapy platform thiab muaj peev xwm. NeuExcell' pab pawg tshawb fawb yuav ua haujlwm ze nrog Spark Therapeutics txhawm rau txhim kho qhov project. Raws li daim ntawv tso cai xaiv, NeuExcell tsim nyog tau txais cov nyiaj them ua ntej, nqi daim ntawv tso cai, R& D thiab kev muag khoom tseem ceeb them, txog li kwv yees li US $ 190 lab, ntxiv rau cov khoom lag luam. Spark Therapeutics muaj cai xaiv rau daim ntawv tso cai NeuExcell' cov cai thoob ntiaj teb tshwj xeeb rau HD project.

Qhov kev pom dav dav tam sim no yog cov neeg laus cov neurons hauv cov tsiaj txhu tsis tuaj yeem hloov tau, yog li kev kho mob ntawm cov kab mob hauv lub hlwb feem ntau tsom rau kev ua kom qeeb ntawm cov kab mob. NeuExcell tej zaum yuav tau pib ib txoj hauv kev tsim kho cov paj hlwb. Lub tuam txhab' lub paj hlwb rov tsim kho noob kho lub platform yog tsim nyob ib ncig ntawm cov khoom siv hloov pauv raws li kev hloov pauv tshuab. Lub platform sim reprogram endogenous glial hlwb (xws li astrocytes) nyob ib puag ncig cov neurons rau hauv cov haujlwm tshiab neurons, uas feem ntau teb tom qab neurons raug mob lossis tuag.

Txawm hais tias cov neurons tsis tuaj yeem faib thiab rov tsim dua lawv tus kheej, glial hlwb yog qhov chaw txuas ntxiv ntawm kev tsim cov neurons tshiab ntawm qhov chaw raug mob, thiab lawv cov nplai loj txaus los tsim cov txiaj ntsig kho mob. NeuExcell tab tom tsim tus kab mob adeno-associated virus (AAV)-raws li paj hlwb regeneration gene therapy kom rov tsim kho cov hlwb tshiab ntawm qhov chaw ntawm neurodegeneration.

Spark Therapy' qhov kev tshaj lij AAV cov neeg nqa khoom platform rau lub hauv paus paj hlwb yuav muab qhov zoo dua rau HD R& D tej yaam num. Lub tuam txhab tau ua tus thawj coj ntawm kev tshawb fawb txog kev kho noob rau ntau tshaj 20 xyoo thiab muaj kev paub dav thiab muaj peev xwm hauv daim teb no, uas yuav siv los txhawb kev txhim kho HD cov haujlwm.

Los ntawm kev sib txuas Spark Therapy' qhov kev txawj ntse uas twb muaj lawm hauv kev kho noob caj noob ces nrog NeuExcell' cov kev tshawb fawb ntawm cov noob caj noob ces neural regeneration, qhov kev sib koom tes no yog tsim los txhawb cov peev txheej ntawm kev kho noob rau Huntington' s kab mob.