Twymeeg (imeglimin) Mus Muag hauv Nyiv: Lub Hom Phiaj Mitochondrial Dysfunction, Cim Mechanism Muab Kev Muaj Peev Xwm Tsis Muaj Peev Xwm!

Poxel SA thiab nws tus khub Sumitomo Dainippon Pharma tsis ntev los no tau tshaj tawm cov phiaj xwm tsim tawm Twymeeg (imegliminhydrochloride, 500mg ntsiav tshuaj) hauv Nyij Pooj thaum lub Cuaj Hlis 16, 2021. Cov tshuaj tuaj yeem siv los ua monotherapy thiab ua lwm yam kev kho mob hypoglycemic. Kev kho ntxiv rau kev kho mob ntshav qab zib hom 2.

Thaum Lub Rau Hli 2021, Twymeeg tau pom zoo hauv Nyij Pooj. Qhov kev pom zoo no yog thawj zaug uas imeglimin tau dhau qhov kev tso npe tso npe thoob ntiaj teb. Nyiv yog thawj lub tebchaws pom zooimeglimin.

Targeting mitochondrial dysfunction, Twymeeg yog ib hom tshiab ntawm qhov ncauj hypoglycemic tus neeg saib xyuas nrog ob lub tswv yim ntawm kev ua, los ntawm kev cuam tshuam rau pancreatic (txhawb cov piam thaj concentration-dependent insulin secretion) thiab ntxiv-pancreatic cuam tshuam ( txhim kho cov piam thaj metabolism hauv lub siab thiab cov leeg pob txha [inhibition ntawm qabzib Kev Noj Qab Haus Huv thiab txhim kho cov ntshav qabzib]) ua lub luag haujlwm hauv kev txo cov ntshav qab zib.

Twymeeg (imeglimin) yog Poxel' thawj cov khoom lag luam. Sumitomo Pharmaceuticals tau tsim kev sib koom tes nrog Poxel thaum Lub Kaum Hli 2017 los tsim thiab ua lag luamimegliminHauv Nyiv, Tuam Tshoj (xws li Taiwan), Kaus Lim Qab Teb thiab 9 lwm lub tebchaws Esxias sab hnub tuaj.

Nyiv kev tswj hwm kev pom zoo ua rau muaj kev them nyiaj tseem ceeb ntawm 1.75 billion yen (kwv yees li 13.3 lab euros) rau Poxel SA los ntawm Sumitomo Pharmaceuticals. Tsis tas li ntawd, tom qab cov khoom tawm mus rau hauv kev ua lag luam, Poxel tsim nyog tau txais 2-tus lej royalties raws li kev muag khoom thiab kev them nyiaj raws li cov hom phiaj muag, txog li 26.5 billion yen (kwv yees li 200 lab euros).

imeglimin chemical qauv

Imeglimin yog cov tshuaj thawj zaug hauv chav kawm nrog cov txheej txheem tshiab ntawm kev ua haujlwm (MOA) lub hom phiaj mitochondrial tsis ua haujlwm, uas tuaj yeem txhim kho insulin secretion disorders thiab insulin rhiab heev, ob qho tib si yog qhov tseem ceeb ua rau mob ntshav qab zib hom 2. Imeglimin muaj ib qho tshwj xeeb ntawm ob lub tswv yim ntawm kev ua haujlwm thiab muaj peev xwm kho mob ntshav qab zib hom 2 hauv txhua theem ntawm cov qauv kho tam sim no. Nws tuaj yeem siv los ua monotherapy lossis ntxiv rau lwm cov kev kho mob hypoglycemic.

Hauv Nyij Pooj, qhov kev pom zoo kev tswj hwm ntawm Twymeeg yog raws li cov ntaub ntawv los ntawm Phase III qhov kev txhim kho kho mob TIMES. Txoj haujlwm no suav nrog 3 qhov tseem ceeb ntawm Kev Kawm Qib III (TIMES1, TIMES2, TIMES3), suav nrog ntau dua 1,100 tus neeg mob hauv Nyij Pooj. Hauv cov kev tshawb fawb no, koob tshuaj imeglimin yog 1000 mg ntawm qhov ncauj ob zaug ib hnub. Hauv tag nrho peb qhov kev sim, imeglimin tau mus txog qhov kawg ntawm cov ntsiab lus thiab cov hom phiaj: cov txiaj ntsig tau lees paub qhov ua tau zoo thiab kev nyab xeeb ntawm imeglimin raws li kev kho mob monotherapy, ua ke nrog kev lag luam ntawm qhov ncauj hypoglycemic tshuaj lossis insulin npaj, hauv kev kho mob ntawm Japanese hom 2 mob ntshav qab zib mellitus, Tolerability.

Kev sib txawv mechanism ntawm imeglimin

Imeglimin yog thawj zaug hauv chav kawm tshiab ntawm cov tshuaj chemical (Glimins) uas muaj tetrahydrotriazine molecules. Nws ntseeg tiasimegliminua rau mitochondria, los ntawm kev cuam tshuam rau pancreatic (txhawb cov piam thaj hauv cov tshuaj insulin secretion) thiab cov teebmeem ntxiv rau pancreatic (txhim kho cov piam thaj metabolism hauv daim siab thiab cov leeg pob txha [inhibiting gluconeogenesis thiab txhim kho cov piam thaj]) kom txo cov ntshav qab zib.

imeglimintuaj yeem ua rau tib lub hom phiaj rau tag nrho peb lub cev tseem ceeb (lub siab, cov leeg, thiab pancreas) koom nrog hauv cov piam thaj homeostasis. Cov txheej txheem no tseem muaj peev xwm tiv thaiv endothelial thiab diastolic tsis ua haujlwm, thiab muaj kev tiv thaiv ntawm microvascular thiab macrovascular defects los ntawm ntshav qab zib. Tsis tas li ntawd, imeglimin kuj muaj peev xwm tiv thaiv txoj sia nyob thiab ua haujlwm ntawm β hlwb.

Cov txheej txheem tshwj xeeb ntawm kev ua no muab imeglimin uas tsis muaj peev xwm los kho hom 2 mob ntshav qab zib mellitus hauv yuav luag txhua theem ntawm cov qauv kho hypoglycemic tam sim no, suav nrog kev kho mob monotherapy lossis kev kho ntxiv rau lwm cov tshuaj hypoglycemic.