Tshuaj qog qis Doxorubicin Yuav dhau mus los ua lub cev tiv thaiv kab mob

Hauv txoj kev tshawb nrhiav tshiab tshaj tawm hauv online ntawm Nature-Cell Biology ntawm lub Plaub Hlis 20 th, Suav cov kws tshawb fawb Suav thiab Asmeskas tau tshaj tawm cov qauv tshiab uas yuav kov yeej cov tshuaj tiv thaiv kab mob ntsws: kev siv cov tshuaj qis yog siv los kho ntau yam Cancer cov tshuaj khomob doxorubicin.

Txawm hais tias kev siv tshuaj kho mob lossis tshuaj tua hluav taws xob rau kev mob qog nqaij hlav muaj qee yam tshwm sim thaum ntxov ntawm kev kho, qhov kev tawm tsam nws tshwm sim feem ntau ua rau mob qog noj ntshav. Xyoo tsis ntev los no, kev sim tshuaj tiv thaiv kab mob kev tiv thaiv kab mob (tiv thaiv kab mob) tau dhau los ua txoj kev kho mob qog nqaij hlav tshiab, tab sis kev tiv thaiv kab mob tsuas pom cov txiaj ntsig zoo hauv kev mob qes, thiab feem ntau ntawm cov neeg mob tseem rov qab tom qab siv tshuaj tiv thaiv. Yog li, cov txheej txheem yooj yim ntawm kev siv tshuaj tiv thaiv suav nrog kev tiv thaiv kev tiv thaiv khiav tawm yog qhov teeb meem tseem ceeb uas yuav tsum tau daws sai.

Sij hawm dhau los, cov kws tshawb nrhiav tau txiav txim siab tias kev tiv thaiv Akt phosphorylation ntawm β-catenin yuav txo qis qhov qub' s kev ua haujlwm thiab inhibit mob leukemia. Txhawm rau sim cov kev xav no, cov kws tshawb fawb los ntawm Asmeskas Stowers Medical Research lub koom haum, University of Kansas, thiab Tsinghua University hauv Suav teb ua cov kev tshuaj ntsuam kab mob siab rau cov tsev qiv ntawv tshuaj pom zoo los ntawm Asmeskas Chaw Tswj Khoom Noj thiab Yeeb Tshuaj thiab nrhiav tau 24 cov tshuaj txhuas. Yog li ntawd, nws tau pom tias cov tshuaj siv tshuaj kho mob doxorubicin tshwj xeeb tshaj yog inhibited kev sib cuam tshuam ntawm Akt thiab β-catenin ntawm kev txhaj tshuaj qis.

Cov kws tshawb nrhiav tau siv cov tshuaj doxorubicin tsawg kawg ua ke nrog cov kws khomob siv tshuaj tua kab mob nairabine los kho ob tus nas me. Lawv tau pom tias kev siv tshuaj kho mob tuaj yeem tshem tawm cov feem ntau ntawm cov roj ntsha leukemia, tab sis qhov tsim kev nthuav dav ntawm qee tus neeg mob hlwb leukemia. Hauv kev sib piv, cov koob tshuaj doxorubicin tsawg dua tsis muaj cov teebmeem rau cov ntshav muaj leukemia, tab sis txo cov roj ntsha qog ua ntshav. Kev sib xyaw ntawm tsawg-koob tshuaj doxorubicin thiab nairabine muaj qhov zoo tshaj plaws. Txhawm rau kom paub tseeb ntxiv cov nyhuv inhibitory, cov kws tshawb nrhiav tau sib koom tes hauv kev sim tshuaj me me los sim cov lus teb ntawm 10 rau 20 cov neeg mob uas muaj tus mob myeloid zoo uas tau tsim kho cov tshuaj kho mob rau daunorubicin. Cov txiaj ntsig tau pom tias 50% ntawm cov neeg mob uas muaj tus mob myeloid zoo uas twb tau siv tshuaj kho mob tau teb rau daunorubicin tsawg thiab txo cov neeg mob hlwb mob hlwb.

Txoj kev tshawb nrhiav tseem pom tias cov nyhuv inhibitory txo qis-doxorubicin ntawm cov roj ntsha qog ua haujlwm nyob ntawm cov qog ntshav tiv thaiv T hlwb qhia tawm CD 8. Yog li, txoj kev kho tshiab tsis tsuas yog tsom cov neeg mob ntshav qia hlwb ncaj qha, tab sis kuj tseem ua rau lawv txais cov lus teb rov qab tiv thaiv kab mob. (Bioon.com)