Heplatin's Batoclimab Theem 1 b / 2 Kev Tshuaj Ntsuam Xyuas Ua tiav Tus Thawj Neeg Mob

Heplatin Cov Chaw Muag Tshuaj tau tshaj tawm tias nws qhov kev tiv thaiv kab mob rau tib neeg los tiv thaiv FcRn batolimab (HBM 9161) tau ua tiav thawj tus neeg mob tuaj rau hauv qhov chaw soj ntsuam theem 1 b / 2 ib qho kev kawm txog optic neuromyelitis spectrum kab mob. Cov kev tshawb fawb soj ntsuam no tsom rau kev nyab xeeb, kev tiv taus, cov chaw muag tshuaj, thiab kev ua tau zoo ntawm batolimab (HBM 9161) hauv cov neeg mob uas muaj kab mob optic neuromyelitis spectrum kab mob hauv Suav. Qhov no tseem yog lub ntiaj teb' s thawj zaug kawm txog tshuaj tiv thaiv FcRn phiaj tshuaj hauv optic neuromyelitis caj ces mob.

Batoclimab (HBM 9161) yog cov tshuaj tiv thaiv kab mob hauv tib neeg lub hom phiaj kom zoo rau neonatal Fc receptor (FcRn). Nws tuaj yeem kho qhov sai sai ntawm cov kab mob autoantibodies hauv cov neeg mob uas cov kab mob optic neuromyelitis spectrum kab mob thiab lwm yam kab mob autoimmune. Raws li nws lub tswv yim tsim kho tshiab thiab cov kev xav tau tsis zoo ntawm cov kab mob autoimmune hauv Suav teb, Heplatin Tshuaj yuav ua nws qhov zoo tshaj plaws los txhawb nws txoj kev tiv thaiv kab mob nrog rau myasthenia gravis, thyroid qhov muag kab mob, optic neuromyelitis spectrum kab mob, cov laus tiv thaiv kab mob thrombocytopenia Kev kuaj mob ntawm kev sib deev.

Optic neuromyelitis (NMO) yog kev tiv thaiv kab mob kev tiv thaiv kab mob hauv lub nruab nrab cov hlab ntsha uas feem ntau cuam tshuam rau cov leeg kho qhov muag thiab pob txha caj qaum. Nws yog tus cwj pwm mob viav vias mob rau hauv tus txha caj qaum thiab cov hlab qhov muag uas tuaj yeem ua rau tuag tes tuag taw thiab dig muag. Nws lub ntsiab pathogenesis yog vim muaj kev sib txuas ntawm pathogenic IgG rau nws lub hom phiaj AQP 4, thiab ua kom muaj kev cuam tshuam-cytotoxicity thiab theem nrab mob, nrog los ntawm infiltration ntawm granulocytes thiab macrophages, kev rhuav tshem cov ntshav-hlwb teeb meem thiab oligodendrocytes kev puas tsuaj. Cov. Hauv 2015, International NMO Diagnostic Group (IPND) tau tsim cov kev soj ntsuam tshiab rau cov kab mob ntawm cov kab mob tsis muaj qhov muag (NMOSD), tau muab cov ntsiab lus cais ntawm NMO cais, thiab muab NMO tso rau hauv ntau cov kabmob NMOSD.