Ib Qho Tshiab Cov Tshuaj Hypoglycemic Tshuaj Imeglimin Xa Daim Ntawv Thov Hauv Ntiaj Teb Cov Ntawv Thov Ua Ntej: Qhov Kev Txawv Ntawm Qhov Siv Tau Siv Peev Xwm Tsis Muaj Peev Xwm!

Poxel SA yog lub tuam txhab biopharmaceutical chaw ua haujlwm nyob Lyon, Fabkis, mob siab rau kev tsim kho tshiab rau kev kho mob rau cov kab mob metabolic, suav nrog cov ntshav qab zib hom 2 thiab cov ntshav tsis haum cawv (NASH). Tsis ntev los no, lub tuam txhab tshaj tawm tias nws tus khub Sumitomo Dainippon Pharma tau xa Daim Ntawv Thov Tshuaj Tshiab (NDA) hauv Nyij Pooj rau qhov tshuaj tiv thaiv kab mob ntshav qab zib tshiab imeglimin, uas yog siv los kho ntshav qab zib hom 2. Ob tog cia siab tias tom qab kev pom zoo, imeglimin yuav mus muag rau xyoo 2021.

Imeglimin yog thawj-hauv-chav tshuaj uas muaj tus txheej txheem tshiab ntawm kev ua (MOA) kev tsom rau mitochondrial bioenergetics, uas tuaj yeem txhim kho insulin secretion cuam tshuam thiab insulin rhiab heev, ob qho tib si yog qhov tseem ceeb ua rau muaj ntshav qab zib hom 2. Imeglimin muaj qhov tshwj xeeb dual mechanism ntawm kev ua thiab muaj lub peev xwm los kho tus mob ntshav qab zib hom 2 hauv txhua theem ntawm cov qauv kho tam sim no. Nws tuaj yeem raug siv los ua tshuaj kho mob lossis ntxiv rau lwm qhov kev kho ntshav qab zib.

Daim ntawv thov no yog saib raws cov ntaub ntawv los ntawm Theem III kev kho mob hauv phiaj xwm kev tsim kho. Txoj haujlwm suav nrog 3 qhov kev tshawb fawb tseem ceeb nyob qib III (TIMES1, TIMES2, TIMES3), koom nrog ntau dua 1,100 tus neeg mob hauv Nyij Pooj. Hauv cov kev tshawb fawb no, koob tshuaj imeglimin yog 1000 mg, qhov ncauj ob zaug ib hnub. Cov txiaj ntsig ntawm txoj kev tshawb fawb tau lees paub cov kev ua tau zoo, kev nyab xeeb, thiab kev thev taus ntawm imeglimin uas yog tshuaj kho mob, ua ke nrog kev lag luam tshuaj hauv qhov ncauj hypoglycemic lossis insulin npaj, los kho cov neeg mob ntshav qab zib hom 2.

Kev xa ntawm Nyij Pooj NDA ua rau muaj kev txhim kho kev vam meej them nyiaj ntau txog 500 lab yen (kwv yees li 4.1 lab daus las) los ntawm Sumitomo Pharmaceuticals mus rau Poxel SA. Ib qho ntxiv, thaum imeglimin tau txais kev pom zoo, Poxel tau tsim nyog rau kev them nqi tseem ceeb ntawm 17.5 billion yen (kwv yees li 1,42 lab euros). Tom qab cov khoom lag luam mus rau tom khw, Poxel tsim nyog tau txais 2-lej muaj txiaj ntsig raws li kev muag khoom thiab them nyiaj raws li cov hom phiaj muag.

imeglimin chemical qauv (duab los ntawm: Wikipedia)

Imeglimin belongs rau cov chav kawm tshiab ntawm kev npaj tshuaj hauv qhov ncauj hu ua Glimins. Nws yog thawj tus neeg sib tw khoom ntawm hoob kawm ntawm cov tshuaj no kom nkag mus kho mob. Nws muaj cov txheej txheem tshwj xeeb ntawm kev nqis tes ua, lub hom phiaj mitochondrial bioenergetics, thiab yog tus tsuas yog ib qho uas tuaj yeem sib txuas ua ke Qhov ncauj tshuaj hypoglycemic hauv lub cev uas ua haujlwm hauv tag nrho peb lub plab hnyuv siab raum (nplooj siab, leeg, thiab txiav) rau cov ntshav qabzib homeostasis.

Imeglimin tau ua pov thawj rau txo cov ntshav qab zib los ntawm kev ua kom cov kua dej ntau ntxiv, txhim kho cov tshuaj insulin, thiab inhibiting gluconeogenesis. Qhov kev ua haujlwm ntawm kev ua haujlwm no tseem muaj peev xwm tiv thaiv endothelial kawg thiab diastolic kawg, thiab muaj cov kev tiv thaiv ntawm microvascular thiab macrovascular cov teeb meem tshwm sim los ntawm ntshav qab zib. Ntxiv rau, imeglimin tseem muaj qhov ua kom zoo tiv thaiv kev muaj sia nyob thiab ua haujlwm ntawm β hlwb.

Qhov kev hloov kho uas tsis tseem ceeb no muab cov imeglimin uas tsis muaj peev xwm kho tus mob ntshav qab zib hom 2 nyob rau yuav luag txhua theem ntawm cov qauv kev kho mob ntshav qab zib tam sim no, suav nrog kev kho mob monotherapy lossis ntxiv cov tshuaj ntxiv rau lwm cov tshuaj hypoglycemic.

Poxel thiab Sumitomo Pharmaceuticals tau tsim txoj kev sib koom tes koom ua ke nyob rau lub Kaum Hlis 2017 los tsim thiab ua lag luam imeglimin rau kev kho mob ntshav qab zib hom 2 hauv Nyiv, Suav, Kaus Lim Qab Teb thiab 9 lwm cov teb chaws Esxias yav Qab teb sab hnub tuaj thiab Asia. Thaum Lub Ob Hlis 2018, Roivant Sciences thiab Poxel tau kos npe rau $ 650 lab kev pom zoo los tsim thiab ua lag luam imeglimin hauv kev ua lag luam sab nraud ntawm cov teb chaws thiab thaj chaw, suav nrog Tebchaws Meskas thiab European Union. Tam sim no, Metavant Sciences thiab Poxel, cov tuam txhab nyob hauv Roivant Science, tab tom npaj yuav ua lub luag haujlwm III kho mob hauv Tebchaws Meskas thiab European Union.