2021 AACR: Bayer Cov Kev Npaj Mus Tshaj Tawm INHL Theem III Cov Ntaub Ntawv Soj Ntsuam Thiab Nws Txoj Kev Kawm Oncology

Raws li cov lus ceeb toom, Bayer npaj yuav qhia nws txoj kev tshawb fawb tshiab hauv kev ncig oncology ntawm virtual American Association rau Cancer Kev Tshawb Fawb (AACR) lub rooj sib tham txhua xyoo hauv 2021. Cov ntaub ntawv raws li theem III randomized, ob-dig muag, qhov chaw tswj hwm chaw kho mob. kev kawm uas siv Aliqopa (copanlisib) ua ke nrog rituximab rau cov leeg mob txhawm rau kho cov neeg mob uas tsis rov mob dua li tsis-Hodgkin' s lymphoma (iNHL) tom qab ≥1 chav kawm ntawm kev kho mob kom rov zoo, suav nrog rituximab (CHRONOS-3).

Hauv 2017, raws li cov txiaj ntsig ntawm ib txhais caj npab, ntau lub chaw, theem II hauv kev soj ntsuam kuaj mob CHRONOS-1, Aliqopa tau pom zoo rau kev kho mob rau cov neeg mob laus uas muaj cov kab mob ua paug rov qab los ua kab mob (FL) uas tau txais tsawg kawg ob txoj kev kho mob. ua ntej. Raws li tus lej teb tag nrho (ORR), kev pom zoo nrawm ntawm qhov ntsuas, qhov kev pom zoo txuas ntxiv ntawm qhov kev ntsuas no yog nyob ntawm kev txheeb xyuas qhov tseeb thiab piav qhia txog cov txiaj ntsig kho mob hauv kev sim tshuaj xyuas.

Hauv lub rooj sib tham no, Bayer tseem yuav nthuav tawm cov ntaub ntawv tsim nyog ntawm kev siv tshuaj tua kab mob biomarker. Vitrakvi (larotrectinib) yog thawj TRK inhibitor rau TRK fusion mob cancer hauv cov qog, nrog rau cov kev ua kom ntev ntawm TRK fusion mob cov neeg mob uas tau txais Vitrakvi, thiab 100,000 cov neeg muaj caj ces engineering cov ntaub ntawv tshawb fawb ntawm cov khoom muaj feem nrog neurotrophic receptor tyrosine Kev muaj sia nyob ntawm cov neeg mob qog nrog kua qaub kinase (NTRK) noob fusion. Cov ntaub ntawv tshiab dua tau lees paub Bayer' s kev siv zog mus kawm kev soj ntsuam kev cuam tshuam ntawm kev siv biomarker rau cov neeg mob.

Vitrakvi tau txais kev pom zoo rau kev kho mob ntawm cov neeg laus thiab cov menyuam yaus cov tawv nqaij cov neeg mob uas nqa NTRK fusion noob tab sis tsis paub txog kev hloov pauv, kev mob metastasis lossis phais mob phais yuav ua rau muaj kab mob loj, thiab leej twg tsis muaj lwm txoj kev kho zoo lossis kev vam meej tom qab kev kho mob. Cov neeg mob yuav tsum raug xaiv rau kev kho mob raws li kev pom zoo los ntawm FDA, thiab qhov ntsuas no tau txais kev tso cai nrawm raws li tus lej teb tag nrho.

Lub sijhawm no, lub tuam txhab tseem yuav tshaj tawm NUBEQA (darolutamide) kev tshawb fawb qog nqaij hlav cancer rau kev kho mob ntawm non-metastatic castration-resistant prostate cancer (nmCRPC). Xws li NUBEQA tsom xam ntawm androgen kev tsim kho thiab cov ntaub ntawv tshaj tawm txog cov teebmeem ntawm NUBEQA kev kho mob. Tsis tas li ntawd, cov ntaub ntawv ua ntej kho mob ntawm cov nyhuv los tiv thaiv qog ua ke ntawm kev tshawb fawb Xofigo thiab enzalutamide kev coj ua ke hauv LNCaP prostate cancer xenograft qauv hauv tibia yuav muab. TTCs yog hom tshiab ntawm cov hom phiaj alpha radiotherapy, uas tej zaum yuav yog txoj kev kho rau cov neeg mob qog noj ntshav. Cov kev tshawb fawb tshwj xeeb TTC yuav hais txog PSMA-TTC BAY 2315497 (raug lees paub los tsom hom prostate tshwj xeeb antigen (PSMA) hauv qog nqaij hlav prostate) thiab nws siv nrog kev sib xyaw nrog PARP inhibitor olaparib hauv preclinical prostate cancer qauv tiv thaiv qog ua haujlwm hauv. PSMA -TTC tseem tab tom raug kawm nyob rau theem kuv kawm. Cov ntaub ntawv no ntxiv rau Bayer' s kev tshawb nrhiav cov qauv thiab txhawb lub tuam txhab' s kev cog lus los pab tus txiv neej tau txais kev kho mob tsim nyog hla ntau theem ntawm prostate cancer.

NUBEQA yog androgen receptor inhibitor (ARi) nrog cov qauv tshuaj tshwj xeeb uas muaj peev xwm sib tw los tiv thaiv androgen khi, AR nuclear hloov chaw thiab AR-mediated hloov. NUBEQA yog siv hauv Tebchaws Asmeskas los kho cov tsis muaj metastatic castration-resistant prostate cancer. Xofigo yog qhov tsim nyog rau kev kho mob ntawm kev tawm tsam prostate-resistant prostate cancer, mob pob txha metastases, thiab cov neeg mob tsis paub visceral metastases.

Bayer tseem yuav tso tawm cov ntaub ntawv tshiab tshaj plaws ntawm nws qhov sib txawv ntawm cov kav dej sib txawv thaum ntxov hauv lwm qhov chaw tseem ceeb, suav nrog qhov ntsuas cov thev naus laus zis thiab kev txhaj tshuaj tiv thaiv kab mob. Thawj thawj zaug, Bayer yuav muab cov ntaub ntawv tseem ceeb ntawm kev tshawb nrhiav me me cov qauv tshuaj tiv thaiv kab mob kev loj hlob (EGFR) exon 20 inhibitor BAY 2476568. Qhov kev tshawb pom tau ua los ntawm kev sib koom ua ke ntawm kev tshawb fawb ntawm cov tuam txhab thiab Massachusetts Institute of Technology thiab Harvard University. Bayer yuav nthuav tawm qhov kev nrhiav pom ntawm qhov ncauj kev tshawb nrhiav qhov ncauj me me molecule inhibitor BAY-405.