Xwm sub-tshaj tawm lwm txoj hauv kev kho mob qog noj ntshav! Ua kom nce qib kev ua tiav los ntawm 20% txog 75%?

Raws li ib qho kev npau suav loj tshaj plaws hauv keeb kwm ntawm tib neeg kab mob, mob qog noj ntshav tau ib txwm hu ua&"huab tais ntawm txhua yam kab mob &"; vim nws qhov nyuaj thiab qhov ua tsis tau. Txawm hais tias lawv yog neeg nplua nuj los yog neeg pluag, lawv raug coj los sib luag thaum lawv coj tib neeg txoj sia.

Xyoo tsis ntev los no, txhawm rau txhawm rau kov yeej kev cuam tshuam ntawm kev mob qog noj ntshav hauv tib neeg kev noj qab haus huv, ntau tus kws tshawb fawb tau mob siab rau ntau lub sijhawm thiab lub zog los tshawb fawb hauv cov haujlwm ntsig txog mob qog noj ntshav.

Xyoo 2013, ntawm American Oncology Annual Conference (hu ua ASCO hauv kev lag luam), tshuaj hu ua" tiv thaiv kab mob tiv thaiv kab mob" ci ntsa iab vim yog lawv cov tshuaj tiv thaiv qog zoo, thiab dhau los ua lub rooj sib tham&"; Lub hnub qub ci tshaj plaws&"; Hauv tib lub xyoo," New York Times" ntawm Tebchaws Meskas thiab muaj cai tshaj" Science" cov ntawv xov xwm hauv kev tshawb fawb ntuj xwm txheej hu ua lub chaw tiv thaiv kab mob tiv thaiv kab mob rau kev kho mob qog noj ntshav raws li&"Top Ten Breakthroughs &"; nyob rau hauv natural science ntawm lub xyoo.

Tab sis tsis yog txhua tus neeg mob qog noj ntshav teb rau qhov tshuaj tiv thaiv kab mob no. Piv txwv li, tsuas yog 20% ​​ntawm cov neeg mob melanoma muaj txoj hauv kev kho tau.

Ib qho kev piav qhia vim li cas ntau qhov kev tiv thaiv kab mob tsis teb zoo yog tias lub chaw tiv thaiv kab mob tiv thaiv kab mob tso siab rau lub cev kom pib ua lub cev tiv thaiv kab mob, uas tom qab ntawd ua rau lub cev tiv thaiv tsis tau ntev. Yog tias tib neeg lub cev tsis tuaj yeem lees paub nws cov qog qog ua lub cev txawv teb chaws, tom qab ntawd cov tshuaj tiv thaiv kab mob tiv thaiv kab mob yuav tsis muaj lub cev tiv thaiv kab mob ua haujlwm.

Yog li ntawd, yuav ua li cas txhawm rau txhim kho kev ua tau zoo ntawm cov tshuaj tiv thaiv kab mob uas twb muaj lawm xws li tshuaj tiv thaiv kab mob tiv thaiv kab mob tau dhau los ua qhov tseem ceeb heev.

Tsis ntev los no, kws tshuaj tiv thaiv kab mob los ntawm University of Konstanz tau tshaj tawm tsab ntawv tshawb fawb hu ua" PLGA-cov tshuaj tiv thaiv kab mob nqa TLR3/RIG-I ligand Riboxxim ua ke nrog kev tiv thaiv kab mob tiv thaiv kev tiv thaiv kab mob qog noj ntshav kom zoo&" hauv phau ntawv xov xwm Nature Communications. . Txoj kev tshawb no qhia tias tshuaj tiv thaiv kab mob qog noj ntshav tshiab tuaj yeem txhim kho qhov txiaj ntsig zoo ntawm cov tshuaj tiv thaiv kab mob uas twb muaj lawm, ua rau kom muaj kev kho tiav los ntawm 20% txog 75%.

Duab qhov chaw: https://www.nature.com/articles/s41467-021-23244-3

Hauv txoj kev tshawb fawb no, pab pawg tshawb fawb tau tsim tshuaj tiv thaiv kab mob qog noj ntshav:&"Riboxxim &". Qhov tshuaj tiv thaiv kab mob qog noj ntshav me me no siv cov tshuaj tiv thaiv kab mob uas tau pom zoo siv rau tib neeg, uas tuaj yeem pib tus neeg mob' tiv thaiv kev tiv thaiv kab mob rau qog. Nws tuaj yeem txhawb lub cev' T cell teb, yog li txhawb kev ua haujlwm ntawm cov tshuaj tiv thaiv kab mob tiv thaiv kab mob.

Nano lossis micron PLGA hais txog muaj cov protein pebble (OVA) thiab carboxyoxime yog cov tshuaj tiv thaiv kab mob zoo rau kev txhaj tshuaj tiv thaiv kab mob. Cov tshuaj tiv thaiv kab mob me me muaj cov qog nqaij hlav protein thiab Riboxxim molecules.

Pab pawg tsim cov khoom me me nrog qhov loj me ntawm 1 micron (lossis 0.001 mm), suav nrog cov qog nqaij hlav protein thiab Riboxxim, cov qauv uas ua rau lub cev tiv thaiv kab mob pib ua cov lus teb, tsim los ntawm Riboxx Pharmaceuticals hauv Dresden, Lub Tebchaws Yelemees. Los ntawm suav nrog cov qog nqaij hlav thiab Riboxxim cov lwg me me hauv cov microparticles, lawv tau txhaj rau hauv cov nas sim. Tom qab tau txhaj tshuaj tiv thaiv kab mob me me no, cov nas sim tau tsim cov tshuaj tiv thaiv qog tiv thaiv kab mob tseem ceeb, thiab cov lus teb no tseem tuaj yeem kuaj pom 8 lub lis piam tom qab.

Riboxxim cov tshuaj tiv thaiv kab mob microparticle tuaj yeem ua rau muaj kev loj hlob ntawm CD8+ T cells thiab ua rau cov tshuaj tiv thaiv qog tiv thaiv kab mob tsis zoo.

Txawm li cas los xij, vim yog kev tswj hwm lub cev' kev tiv thaiv kab mob tsis zoo, cov qog hauv cov nas yuav maj mam rov zoo li 30 hnub tom qab txhaj tshuaj tiv thaiv kab mob. Yog li, txhawm rau txhawm rau tua cov qog nqaij hlav tag, cov kws tshawb fawb tau ua ke cov tshuaj tiv thaiv kab mob nrog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob. Qhov kev kho ua ke no tau qhia txog kev kho kom zoo dua qub, thiab cov qog nqaij hlav nas kuj tseem raug tshem tawm.

Pab pawg tshawb fawb tau sim tshuaj tiv thaiv kab mob qog noj ntshav ntau yam, suav nrog mob qog noj ntshav prostate, mob qog noj ntshav thiab mob qog noj ntshav. Lub zog tiv thaiv kab mob ntawm tes tiv thaiv tag nrho cov antigen tawg tsam tau txais hauv cov nas, qhia tias txoj hauv kev tshiab tuaj yeem siv rau ntau hom qog nqaij hlav.

Txawm li cas los xij, vim yog kev cai tswj hwm tib neeg txoj kev tiv thaiv kab mob tsis zoo, pab pawg pom hauv txoj kev tshawb fawb tias cov qog maj mam rov tshwm sim 30 hnub tom qab txhaj tshuaj tiv thaiv kab mob. Txawm li cas los xij, yog tias siv tshuaj tiv thaiv kab mob ua ke nrog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob, cov txiaj ntsig kho yuav txuas ntxiv mus thiab cov qog yuav raug tshem tawm.

Hauv qhov no, thawj tus kws sau ntawv ntawm txoj kev tshawb fawb no, Xibfwb Dennis Horvath thiab xibfwb Julia Koerner tau hais tias: "Peb tuaj yeem tsim kho kev kho mob qog noj ntshav uas siv tshuaj kho mob uas ua tiav cov tshuaj tiv thaiv kab mob." Horvath yog tus tswv cuab ntawm University of Konstanz (CASCB). ) Ib tus kws kho mob cov tub ntxhais kawm ntawv ntawm Lub Chaw Zoo Tshaj Plaws rau Kev Tshawb Fawb Txog Kev Coj Tus Cwj Pwm. Nws kuj tseem siv txoj kev txhaj tshuaj no los kawm txog kev cuam tshuam ntawm kev nyuaj siab hauv zej zog ntawm kev tiv thaiv kab mob ntawm cov nas, thiab txhawm rau ntsuas seb puas muaj kev tiv thaiv kab mob los ntawm kev ntxhov siab yuav txwv txoj kev txhaj tshuaj tiv thaiv kab mob.

Kev tiv thaiv kab mob tiv thaiv kab mob CTLA-4 txhim kho kev kho mob ntawm kev tiv thaiv kab mob qog noj ntshav siv PLGA-MP, ua rau cov qog loj tuaj thiab ua kom lub neej nyob ntev.

Raws li kev tshawb pom ntawm txoj kev tshawb fawb no, cov kws tshawb fawb pom zoo tias cov txiaj ntsig zoo no tau muab txhais ua cov ntawv kho mob. Groettrup tau hais tias:" Qhov no yuav muaj txiaj ntsig zoo rau kev tiv thaiv kab mob ntawm qee hom mob qog noj ntshav."

Tam sim no, Dutch txoj haujlwm koom tes ntawm pab pawg tshawb fawb tab tom sim cov tswv yim kho tsim hauv txoj kev tshawb fawb no hauv thawj theem me me 1 kev sim tshuaj, vam tias kev kho mob tuaj yeem ua tiav tib yam kev ua tau zoo hauv tib neeg daim ntawv thov kev kho mob.

Raws li cov kws tshawb fawb tau nkag mus tob dua thiab nkag mus rau kev tshawb fawb mob qog noj ntshav, lub neej zoo thiab kev muaj sia nyob ntawm cov neeg mob qog noj ntshav kuj tseem yuav zoo dua qub. Cia peb tos ntsoov rau daim ntawv thov kev kho mob ntawm cov txiaj ntsig tshawb fawb no.