Dovato ua tau zoo heev thiab yuav pib ua nyob rau Suav teb thaum Lub Rau Hli!

ViiV Kev Kho Mob yog kev tshawb fawb thiab txhim kho tshuaj HIV/AIDS tshuaj los ntawm GlaxoSmithKline (GSK) thiab Pfizer thiab Shionogi. Tsis ntev los no, lub tuam txhab tshaj tawm 48-lub lim tiam cov ntaub ntawv los ntawm Phase 3 SALSA txoj kev tshawb fawb ntawm 11th International AIDS Society (IAS) HIV Science Conference nyob rau xyoo 2021. Cov txiaj ntsig tau qhia pom tias muaj ntau hom kab mob HIV-1 cov neeg laus uas tau ua tiav kev tiv thaiv kab mob virological thiab muaj yav dhau los tsis tau ntsib virological tsis ua haujlwm, hloov mus rau ib-ntsiav tshuaj ob-tshuaj regimen (2DR) Dovato (dolutegravir/lamivudine tshuaj, DTG /3TC, 50mg) /300mg), piv nrog txuas ntxiv kom tau txais cov tshuaj tiv thaiv kab mob tiv thaiv kab mob tam sim no tam sim no (CAR) suav nrog tsawg kawg 3 tshuaj, nws pom tias tsis muaj txiaj ntsig zoo li kev ua tau zoo, tsis muaj cov neeg mob virological tsis ua haujlwm, thiab tsis muaj neeg mob tsim tshuaj tiv thaiv kab mob.

SALSA txoj kev tshawb fawb pejxeem muab cov neeg sawv cev dav dav ntawm cov neeg laus uas muaj tus kabmob HIV-1 uas raug kho nrog ntau yam tshuaj tiv thaiv kab mob tiv thaiv kab mob tiv thaiv kab mob (CAR) suav nrog yam tsawg 3 yam tshuaj uas niaj hnub siv niaj hnub no. Txoj kev tshawb fawb no suav nrog ntau dua 120 lub chaw tshawb fawb hauv North America, Europe, Asia Pacific, South America, thiab Africa, thiab suav nrog ib feem tseem ceeb ntawm cov poj niam cov neeg mob (39%), cov neeg mob hnub nyoog 50 xyoo lossis tshaj saud (39%), thiab cov neeg mob ntawm haiv neeg sib txawv (59% dawb, 19% dub, 14% Neeg Esxias).

Nws yog qhov tsim nyog hais tias SALSA txoj kev kawm yog kev tshawb fawb kho mob thib ob los ua pov thawj qhov tsis zoo ntawm Dovato' kev ua haujlwm zoo thiab muaj kev tiv thaiv siab. 48-lub lim tiam cov ntaub ntawv los ntawm SALSA txoj kev tshawb fawb sawv cev rau cov neeg mob sib txawv thiab ua pov thawj tias kev hloov mus rau ob txoj kev siv tshuaj Dovato muaj qhov tsis zoo thiab muaj kev nyab xeeb raws li kev ua tau zoo piv nrog txuas ntxiv kom tau txais kev kho dav dav suav nrog tsawg kawg 3 tshuaj. zoo heev. Cov ntaub ntawv no ntxiv dag zog rau daim ntawv thov Dovato hauv kev hloov pauv kev kho ib puag ncig.

Tus thawj kws tshawb fawb ntawm SALSA txoj kev tshawb fawb, Dr. Josep Llibre, Lub Tsev Haujlwm Saib Xyuas Kab Mob Sib Kis, Puyol University Tsev Kho Mob hauv Barcelona, ​​tau hais tawm:&"; Nws zoo siab heev uas cov ntaub ntawv qhia ntxiv txog Dovato' kev ua tau zoo thiab muaj tshuaj ntau tiv thaiv teeb meem, qhia tias cov neeg mob tuaj yeem siv tau ntau Nws tuaj yeem tswj hwm HIV thaum siv tshuaj tsawg. Muab hais tias cov pej xeem cov ntaub ntawv ntawm SALSA txoj kev tshawb fawb sawv cev rau cov neeg muaj tus kabmob HIV uas peb pom hauv kev coj ua niaj hnub, suav nrog poj niam, cov neeg muaj hnub nyoog 50 xyoo, thiab ntau pawg neeg sib txawv, cov txiaj ntsig ntawm txoj kev tshawb fawb no muaj txiaj ntsig tshwj xeeb. Cov kev tshawb pom no muab cov kws kho mob lwm qhov laj thawj kom ntseeg tau tias cov neeg mob uas tau ua tiav kev tiv thaiv kab mob virological yuav tig mus rau qhov kev kho tshuaj ob."

Dovato ua tiav, ib zaug ib hnub, ib ntsiav tshuaj, ob hom tshuaj (2DR), suav nrog kev tsau tshuaj ntawm dolutegravir (DTG, 50mg) thiab lamivudine (3TC, 300mg). Ntawm lawv: Dolutegravir yog lub cim thib ob HIV sib txuas sib txuas hloov pauv hloov pauv (INSTI), uas thaiv qhov rov ua dua ntawm HIV los ntawm kev tiv thaiv kev sib koom ntawm cov kab mob DNA mus rau hauv cov khoom sib txuas ntawm tib neeg lub cev tiv thaiv kab mob (T cells), thiab lamivudine yog Ib qho nucleoside thim rov qab transcriptase inhibitor (NRTI), feem ntau siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob rau kev kho mob HIV.

Dovato yog thawj qhov tau pom zoo hauv Tebchaws Meskas thaum lub Plaub Hlis 2019. Nws tau hais qhia rau kev kho cov neeg laus thiab cov tub ntxhais hluas hnub nyoog tshaj 12 xyoos uas tau kis tus kabmob HIV-1 thiab tsis tau paub lossis xav tias tsis kam tiv thaiv integrase inhibitors lossis lamivudine ( hnyav tsawg kawg 40 kg) cov neeg mob. Dovato tsim nyog rau cov neeg suav nrog: kho tshiab (kho thawj kab) HIV-1 cov neeg muaj mob thiab cov uas tau ua tiav kev tiv thaiv kab mob virological (kho kab thib ob) HIV-1 cov neeg muaj mob. Vim yog kev kho mob tshiab, cov neeg mob HIV tam sim no tuaj yeem xav tias yuav nyob ntev li cov neeg zoo tib yam, tab sis cov neeg mob zoo li no tseem ntsib kev kho tshuaj tiv thaiv kab mob mus ib txhis kom muaj kev tiv thaiv kab mob virological. Dovato yog thawj qhov ua tiav, ib hnub ib zaug, ib ntsiav tshuaj, ob hom tshuaj (2DR) pom zoo los ntawm Asmeskas FDA, uas tuaj yeem txo tus naj npawb ntawm kev kis rau ARV tshuaj txij thaum pib ntawm kev kho mob (thawj kab kev kho mob) thaum tswj hwm cov qauv ib txwm muaj txiaj ntsig thiab tiv thaiv kev tiv thaiv siab ntawm peb txoj kev siv tshuaj.

Hauv Suav Teb, Dovato tau pom zoo thaum Lub Peb Hlis 2021 thiab pib thaum Lub Rau Hli 2021. Cov tshuaj yog Tuam Tshoj' thawj zaug ua tiav, ib hnub ib zaug, ib-ntsiav tshuaj AIDS ob txoj kev kho tshuaj, uas tsim nyog rau kev kho mob ntawm tib neeg cov kab mob tiv thaiv kab mob tsis zoo 1 Cov neeg laus thiab cov hluas tshaj 12 xyoos (hnyav tshaj 40 kg) nrog HIV-1 (HIV-1) thiab tsis paub lossis xav tias tsis muaj tshuaj tiv thaiv rau integrase inhibitors lossis lamivudine. Sib piv nrog kev kho peb zaug peb zaug, Dovato tuaj yeem tsis tsuas yog txo cov tshuaj antiretroviral uas tau siv los ntawm cov neeg mob HIV, tab sis tseem ua tiav kev tshawb fawb pov thawj pom muaj kab mob tiv thaiv kab mob.