Ibrutinib CAS TSIS 936563-96-1

Khoom Qhia:

Khoom npe: Ibrutinib CAS TSIS: 936563-96-1

Txhais:

(R) -1- (3- (4-amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl) piperidin-1-yl) prop-2-en- 1-ib;

1 - [(3R) -3- [4-Amino-3- (4-phenoxyphenyl) pyrazolo [3,4-d] pyrimidin-1-yl] piperidin-1-yl] prop-2-en-1-ib ;

1- {3- [4-Amino-3- (4-phenoxy-phenyl) -pyrazolo [3,4-d] pyrimidin-1-yl] -piperidin-1-yl} -but-3-en-1- ib tug;

Tshuaj& Cov Khoom Uas Lub Cev:

Zog: Dawb kom dawb-dawb hmoov.

Ntsuas: ≥99.0%

Qhov ceev: 1.34g / cm3

Melting point: 153-158 ℃

Lub Ntsiab Kub: 715.0 ℃ ntawm 760 mmHg

Flash Point: 386.2 ℃

Qhov Taw Qhia Txaus Nruab Nrab: 1.696

Vapor Siab: 0.0mmHg ntawm 25 ° C

PSA: 99.16000

LogP: 4.73640

Pka: 4.09

Kev Solubility: DMSO: ≥ 30 mg / mL (68.10 mM), H2O:< 0.1="" mg="" ml="">

Chloroform (Me ntsis), Methanol (Me ntsis, Sonicated).

Pawg: Tus Txwv Tshuaj; Cov Tshuaj Hluav Taws Xob; Anticancer; Kws Tshuaj / API Tshuaj Tshuaj Nruab Nrab;

Cov Ntaub Ntawv Kev Nyab Xeeb:

HS Code: 2933599090

Cia:Muab cia rau hauv qhov chaw txias thiab qhuav zoo kaw lub thawv. Cia kom deb ntawm ya raws thiab muaj zog lub teeb / cua sov.

Daim ntawv thov:

Ibrutinib yog qhov ncauj qhov ncauj ntawm Bruton tus mob tyrosine kinase uas tau siv rau hauv kev kho mob refractory lymphocytic mob ntsws (CLL) thiab mantle cell lymphoma. Ibrutinib tsis tau cuam tshuam nrog cov ntshav enzyme nce thaum kho, tab sis tau txuas rau qee yam mob tsawg kawg ntawm kev kho mob rau daim siab mob hnyav thiab ua kom rov mob kab mob siab B.

1 - [(3R) -3- [4-Amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl] -1-piperidinyl] -2-propen-1- oneis ib qho kev xaiv zoo heev Bruton tus tyrosine kinase (Btk) irreversible inhibitor.

Peb lub Hoobkas tsim khoom Ibrutinib, tshuab thev naus laus zis, ruaj khov zis, ua haujlwm zoo.

Cov Ntaub Ntawv Nres: Muaj Hauv Tshuag.

Peb tuaj yeem muab 2-Propen-1-ib, 1 - [(3R) -3- [4-amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl] - 1-piperidinyl] -COA (daim ntawv pov thawj ntawm kev soj ntsuam), piperidin-1-yl] prop-2-en-1-one1- {3- [4-AMino-3- (4-phenoxy-phenyl) -pyrazolo [3, 4-d] pyriMidin-1-yl] -piperidin-1-yl} -propenone MOA (Txoj Kev Ntsuam Xyuas), Ibrutinib (PCI-32765) ROS (Txoj kev ntawm kev sib txuas), 1- {3- [4-Amino-3 - (4-phenoxy-phenyl) -pyrazolo [3,4-d] pyrimidin-1-yl] -piperidin-1-yl} -propenone MSDS (Cov Khoom Siv Kev Nyab Xeeb Cov Ntaub Ntawv) thiab lwm yam kev txhawb nqa rau koj!

Hauv Vitro

Ibrutinib (PCI-32765) xaiv tsis tau B-cell teeb liab thiab ua kom muaj zog. Nws inhibits autophosphorylation ntawm Btk (IC50=11 nM), phosphorylation ntawm Btk' s physiological substrate PLCγ (IC50=29 nM), thiab phosphorylation ntawm ib qho ntxiv nqes kinase, ERK (IC50=13 nM) [1]. Ibrutinib (PCI-32765) inhibits BCR-qhib cov thawj B cell loj hlob (IC50=8 nM). Ua raws li FcγR kev txhawb nqa, Ibrutinib (PCI-32765) inhibits TNFα, IL-1β thiab IL-6 ntau lawm hauv thawj monocytes (IC50=2.6, 0.5, 3.9 nM, feem).

Hauv Vivo

Ibrutinib (PCI-32765) (3.125-50 mg / kg, po) txo cov qib ntawm cov roj ntsha hauv lub cev thiab ua rau muaj kev mob caj dab ntau nyob hauv cov nas. Ibrutinib (PCI-32765) inhibits autoantibody ntau lawm thiab kev loj hlob ntawm lub raum mob rau hauv MRL-Fas (lpr) lupus qauv. Ibrutinib (PCI-32765) (3.125-50 mg / kg, po) txo cov kab mob raum thiab autoantibody ntau lawm hauv MRL-Fas (lpr) nas [1]. Ibrutinib (PCI-32765) (0.1 μM) inhibits kev ua kom muaj kev loj hlob ntawm CLL hlwb, ntxias xaiv cytotoxicity hauv B hlwb piv nrog T cell, tab sis hloov cov kev ua kom muaj T-cell cytokine ntau lawm [2]. Ibrutinib (PCI-32765) koob tshuaj-dependently thiab potently rov qab ua pob qij txha hauv kev kho tus qauv CIA nrog ED50 ntawm 2.6 mg / kg / hnub. Ibrutinib (PCI-32765) tseem tuaj yeem tiv thaiv kev mob caj dab hauv cov qauv CAIA.

peb tuaj yeem muabIbrutinib Thiab Intermediates:

FAQ:

1. Yuav ua li cas kom paub meej tias cov khoom ua tau zoo ua ntej tso cov xaj?

a. Peb yuav muab koj cov khoom lag luam kev cai tshwj xeeb rau koj, thiab peb sim txhua pob ntawm peb cov khoom los ntawm HPLC, GC thiab HNMR thiab lwm yam.

b. Kev kuaj dawb ntawm qee cov khoom xa tuaj yeem xa tuaj, tsuas yog yuav tsum them tus nqi thauj khoom lossis npaj tus neeg xa xov rau peb thiab coj mus kuaj.

c. Xa peb koj cov khoom specifications thiab thov, peb yuav tsim rau koj.

2. Yuav ua li cas thiaj yuam& them nyiaj?

a. Proforma invoice yuav muab xa tom qab koj paub meej ntawm kev txiav txim.

b. Peb tuaj yeem txais kev them nyiaj los ntawm T / T, L / C, DA thiab lwm yam.

3. Yuav ua li cas ntim thiab khaws cia?

a. Pob: 1kg / Aluminium ntawv ci lub hnab nrog Carton nyob sab nraud.

25kg / Fiber nruas nrog ob lub hnab PE sab hauv.

b. Cia: Muab cia rau hauv qhov txias& qhov chaw qhuav, cia kom deb ntawm lub teeb muaj zog thiab kub.

4. Yuav tiv tauj peb li cas?

Koj tuaj yeem sib tham nrog peb los ntawm Xa Xa nug thiab sib tham tam sim no ntawm nplooj ntawv khoom.

Lossis online ntawm sab xis thiab Skype Online, yog' s app.

Koj tuaj yeem xaiv koj cov khoom txaus siab thiab xa kev nug rau peb.

Koj tuaj yeem hu peb tus xov tooj ncaj qha, koj yuav tau txais peb lub teb.

Koj tuaj yeem Xa Email rau peb.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: ibrutinib cas tsis muaj 936563-96-1, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: 1-Piperidinecarboxylicacid, 3- [4-amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl] -, 1,1-dimethylethylester, (3R) - CAS TSIS MUAJ 1022150 -11-3
• Tom ntej: Zanubrutinib CAS TSIS: 1691249-45-2