Kev Hloov Cell: Tus txheej txheem ntawm kev txiav txim ntawm dopamine ntawm kev tso ntshav sab xub ntiag

A recent study revealed for the first time how dopamine changes the function of the prefrontal cortex. In this study published in the journal Cell Reports, the researchers found that dopamine had little effect on individual cells. Instead, it produces continuous activity in the collection of cells in the prefrontal cortex for up to 20 minutes.

& quot;Assembling brain cell activities, like the ensemble of musicians performing together, can have a different and greater effect than individual neuronal activity, & quot; the authors said.

The coordinated overall activity triggered by dopamine lasted a few minutes after release. & quot;This may provide a mechanism by which dopamine can support complex functions that must continue, such as motivation and attention to complete tasks. & quot;

Cov kws tshawb nrhiav tau siv optogenetics hauv cov nas lub hlwb thaum lub sijhawm ntsuas, siv lub teeb tsa los txhawb dopamine neurons hauv lub hlwb, thiab tom qab ntawd sau cov lus teb hauv lub prefrontal cortex.

Ntxiv rau qhov tshwm sim ntawm dopamine rau kev ua si tag nrho, txoj kev tshawb no kuj tau qhia txog cov nyhuv ntawm lub hlwb dopamine rau kev ua rau lub hlwb hloov zuj zus. Qhov siab txog - kev cuam tshuam ntau zaus ntawm lub hlwb oscillations yav dhau los cuam tshuam nrog kev saib xyuas thiab lwm yam kab mob xws li mob schizophrenia thiab ADHD, tab sis qhov ua rau muaj kev cuam tshuam no tseem tsis tau paub meej.

Qhov tshawb pom ntawm lub luag haujlwm ntawm dopamine muab kev pom tshiab rau cov txheej txheem tseem ceeb hauv lub hlwb. Dopamine nyob rau hauv qhov prefrontal cortex ntawm lub hlwb ua lub luag haujlwm ntawm yuav luag txhua qhov chaw siab dua - kev txiav txim kom to taub, suav nrog kev saib xyuas thiab tus cwj pwm ua kom yooj yim. Nws tseem cuam tshuam txog kev mob siab thiab kev xav ntawm kev puas hlwb hauv cov kab mob hlwb xws li mob schizophrenia, kev quav yeeb quav tshuaj thiab saib xyuas qhov tsis txaus ntseeg / cuam tshuam. (Bioon.com)

source: & nbsp;Sweyta Lohani li al. & nbsp;Dopamine Modulation of Prefrontal Cortex Activity Is Manifold and Operates at Multiple Temporal and Spatial Scales. & nbsp;Qhia Txog Cell, 2019; 27 (1): 99 DOI: 10.1016/j.celrep.2019.03.012