Tus Kab Mob Cancer: Kev Tshawb Pom Tshiab! Mob hlwb myeloid rau cov ntshav yuav siv cov vitamin B 6 kom loj hlob mus thiab kis tau

Tsis ntev los no, hauv tsab ntawv tshawb fawb tshaj tawm hauv thoob ntiaj teb phau ntawv Xov Xwm Cancer Cell, cov kws tshawb fawb los ntawm Cold Spring Harbour Laboratory thiab lwm lub koom haum tau pom tias mob ntshav qab zib myeloid tuaj yeem siv cov vitamin B 6 txhawm rau nrawm ntawm tes kom yog li, los ntawm kev txwv txoj haujlwm ntawm cov enzymes uas txhawb cov vitamin B 6 los txhawb kev loj hlob ntawm tes thiab kev faib tawm, lossis nws xav tias yuav thaiv kev loj hlob qog nqaij hlav, txoj kev no yuav cuam tshuam kev loj hlob ntawm cov qog nqaij hlav cancer yam tsis muaj teebmeem rau lub hlwb zoo.

Cov duab los ntawm: Zhang lab / CSHL, 2020

Tam sim no, tsuas yog ib feem peb ntawm cov neeg mob AML muaj sia nyob 5 xyoo tom qab kev kuaj mob. Qhov no yog vim tias, zoo li ntau lwm cov qog nqaij hlav ua kom tuag, lub hlwb koom nrog kev loj hlob ntawm cov qog ntshav qog ntshav txuas ntxiv mus thiab sib kis, thiab feem ntau cov tshuaj yuav tsis tuaj yeem tua tau zoo. Cov kws tshawb nrhiav xav paub tias AML ua tiav kev loj hlob sai npaum li cas, yog li lawv tau tshawb xyuas cov noob keeb hauv qog nqaij hlav cancer ntshav thaum pib mob, thiab pom tias ntau dua li 230 noob tau ua haujlwm nyob hauv cov ntshav muaj ntshav roj. Lub noob tau kawm qhov tob.

Siv CRISPR gene kho tshuab, cov neeg tshawb nrhiav tua cov haujlwm ntawm cov caj ces tsis txaus ntseeg kom pom tias tshem tawm cov noob no tuaj yeem thaiv kev loj hlob ntawm cov qog hlwb. Ntawm cov cov noob tau tshawb xyuas los ntawm cov kws tshawb nrhiav, lawv pom ib tus qauv tshwj xeeb ntawm lawv, uas muaj cov gene tsim cov enzyme PDXK, uas pab cov cell siv cov vitamin B 6, uas yog qhov tseem ceeb rau kev mob qog noj ntshav. Txawm hais tias qhov kev cuam tshuam ntawm qee cov vitamins tau yav dhau los xav tias cuam tshuam nrog kev loj hlob mob cancer, cov kws tshawb nrhiav hauv txoj kev tshawb no pom qhov sib txuas tseeb ntawm cov vitamin B 6 thiab mob cancer.

Vitamin B 6 yog qhov tseem ceeb rau cov cell metabolism, kev tsim khoom ntawm lub zog thiab lwm yam kev pab rau kev loj hlob ntawm tes. Hauv cov hlwb noj qab haus huv, PDXK enzymes tuaj yeem tswj hwm kev ua haujlwm ntawm cov vitamin B 6, uas tuaj yeem ua kom cov vitamins muaj peev xwm ua haujlwm thaum xav tau vim tias cov hlwb tsis muaj peev xwm ib txwm faib, yog li PDXK enzymes ib txwm tsis txhawb nqa cov haujlwm ntawm cov vitamin B {{1 .}}. Txawm li cas los xij, qhov no yog lwm lub xeev txawv hauv cov kabmob hlwb. Kab mob khees xaws faib ntau tshaj li cov kab mob hlwb. Hauv AML cov hlwb, PDXK cov enzymes yuav ib txwm txhawb cov haujlwm ntawm cov vitamin B 6.

Ntshav cov qe ntshav muaj yees rau cov vitamin B 6, yog li cov kws tshawb nrhiav pom tau lub hom phiaj muaj feem ua rau mob qog noj ntshav; hauv txoj kev tshawb nrhiav no, cov kws tshawb nrhiav tau qhia tawm tias cov qog nqaij hlav cancer siv cov vitamin B 6 kom loj hlob zoo li cas, tab sis qhov no tsis txhais tau tias cov vitamin B 6 tuaj yeem muaj txiaj ntsig zoo rau cov neeg mob qog nqaij hlav thaum noj ib feem ntawm kev noj haus. Vitamin B 6 kuj tseem yog qhov tseem ceeb rau kev muaj sia nyob ntawm cov hlwb noj qab haus huv. Cov qog nqaij hlav cancer tuaj yeem siv cov PDXK enzymes los ua kom cov haujlwm ntawm cov vitamins B 6, yog li tuaj yeem txhawb txoj kev nce qib thiab kis ntawm AML.

Thaum kawg, tus kws tshawb nrhiav Zhang tau hais tias hauv cov kauj ruam tom ntej, lawv yuav tsim ib cov tshuaj tshwj xeeb los thaiv qhov kev ua haujlwm ntawm cov roj ntsha hlwb kom ua rau PDXK enzymes. Los ntawm kev tswj txoj hauv kev enzyme no txhawb kev ua si vitamin B 6 , cov tshuaj tshiab no yuav tsum cia siab lossis qeeb ntawm kev loj hlob ntawm cov qog nqaij hlav cancer yam tsis muaj teeb meem tshwm sim (tshem tawm cov kev mob tshwm sim ntawm vitamin B {{0 .}} los ntawm cov hlwb zoo). Nws ntseeg tau tias los ntawm kev tshawb nrhiav qhov tob tob los ntawm cov kws tshawb fawb tom qab, lawv yuav muaj peev xwm txhim kho cov tshuaj no los kho AML. (los ntawm Bioon.com, sau hsppharma.com)

Siv:

Chi-Chao Chen, Bo Li, Scott E. Millman, li al. 0010010 nbsp;Vitamin B 6 kev quav rau cov leeg ntshav txha caj qaum myeloid, 0010010 nbsp;Mob Hlwb Cell, Lub Ib Hlis 13, 2020. DOI: 10. 1016 / j.ccell. 2019. 12. {{6)