Acoladine los ntawm Cov Tshuaj Hauv Tebchaws Suav: Cov Kev Txhim Kho Tshiab hauv Kev Tshawb Fawb ntawm Cov Txheej Txheem Me Me Molecule Immunomodulation thiab Kev Tshaj Tawm Mob qog

Tsis ntev los no, European Journal of Immunology, phau ntawv sau xov xwm kev tiv thaiv kab mob hauv ntiaj teb, tau tshaj tawm online ntawm cov kev tshawb fawb ntawm cov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv qog ntshav ntawm Akoladine" (DOI: 10.1002 / eji .202048905).

Acoladine yog chav kawm tshiab 1 Suav tshuaj uas tam sim no tseem tab tom kho mob Lub Tsev III cov kev tshawb fawb los ntawm Beijing Sheng Nuoji Pharmaceuticals. Cov kev tshawb fawb dhau los tau qhia tias Acoladine, raws li cov tshuaj me me uas tau muab los ntawm cov tshuaj Hmoob ib txwm muaj Epimedium, muaj cov khoom tiv thaiv, ncaj qha tiv thaiv qog cell kev loj hlob thiab Anti-qog cell loj hlob immunomodulatory nyhuv.

European Journal of Immunology luam tawm ib tsab ntawv hais txog kev tswj hwm ntawm PD-L1 los ntawm acoradine ntawm lub hau npog ntawm 12th xyoo 2019. NF-KB yog qhov tseem ceeb ntawm lub teeb liab tseem ceeb tshaj plaws ntawm txoj kev hloov pauv ntawm kev siv roj ntsha tiv thaiv kab mob xws li apoptosis, tiv thaiv. -inflammatory, thiab tiv thaiv kev kis, thiab kev ua kom thiab tsiv teb tsaws ntawm NF-KB yog tswj los ntawm cov lwg me me uas tsis xws li IKK. Pab pawg ntawm Beijing Sheng Nuoji thiab cov koom haum tshawb fawb txog kev kho mob tau koom tes hauv kev siv cov txheej txheem biochemical ua ke nrog cov tshuab ntsuas siab siab ntawm cov phiaj xwm molecular, thiab pom tias Akoladine tuaj yeem ncaj qha rau IKKα thiab IKKβ hauv NF-KB cov paib kev taug, thiab cuam tshuam nrog IKK kinase ua txoj. Ua khoom, inhibit qhov kev tsiv teb tsaws ntawm NF-KB los ntawm cytoplasm mus rau lub keeb, yog li down-tswj cov lus qhia ntawm cov tshuaj tiv thaiv kab mob qog ntshav ligand molecule PD-L1.

Cov kev tshawb pom ntawm cov kev tshawb fawb no muab cov hauv paus tseem ceeb molecular rau kev tshawb fawb ntxiv rau ntawm cov teeb liab los tiv thaiv thiab immunomodulatory cov kab mob, los tiv thaiv qog ua cov txheej txheem thiab cov tshuaj sib xyaw ntawm acocladine. Nws yuav tsum ua lub luag haujlwm ntawm qhov tsis tseem ceeb ntawm cov tshuaj me me ntawm cov tshuaj kab mob tsoos suav tshuaj acocladine. Muab ntau lub tswv yim tshiab thiab kev xaiv ntau ntxiv rau kev tshawb fawb txog kev kho mob kom sib xyaw ua ke ntawm cov neeg mob cancer