Hu rau:Errol Zhou (Mr.)
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Ntxiv:1002, Huanmao Tsev, No.105, Mengcheng Txoj kev, Hefei Lub zos, 230061 Tuam Tshoj
CAS TSIS TAU: 737789-87-6
Cov Qauv Nqaij: C29H29F2N7O5S
Molecular Luj: 625.64600
EINECS TSIS TAU: 864-997-1
MDL TSIS TAU: MFCD37789876
Khoom Qhia:
Khoom npe: relugolix CAS TSIS: 737789-87-6
Txhais:
1- [4- [1 - [(2,6-difluorophenyl) methyl] -5 - [(dimethylamino) methyl] -3- (6-methoxypyridazin-3-yl) -2,4-dioxothieno [2,3- d] pyrimidin-6-yl] phenyl] -3-methoxyurea;
TAK-385;
Tshuaj& Cov Khoom Uas Lub Cev:
Tsos: lub teeb daj ua daj
Ntsuas: ≥99.0%
Qhov ceev: 1.442 ± 0.06 g / cm3 (Pom zoo)
Melting point: 228 ℃ (decomp)
Cia: -20 ℃
Solubility Soluble hauv DMSO
Kev ruaj khov: ≥ 2 xyoos
Relugolix (INN) (kev loj hlob kev cai lub npe TAK-385) yog qhov tsis yog peptide, muaj qhov ncauj, muaj kev xaiv tsis haum ntawm gonadotropin-tso cov tshuaj hormones receptor (GnRHR) (IC50=0.12 nM) uas tab tom txhim kho kev siv tshuaj los ntawm Takeda. Nws yog tam sim no nyob rau theem II kev kuaj mob rau kev kho mob ntawm endometriosis, uterine leiomyoma, thiab mob qog nqaij hlav cancer.
Kev tswj hwm qhov ncauj ib leeg ntawm relugolix ntawm koob tshuaj 3mg / kg tau pom tias yuav luteinizing qib tshuaj luteinizing rau ntau tshaj 24 teev hauv castrated cynomolgus liab, qhia hais tias lub sijhawm ua haujlwm ntev. Cov tshuaj (80–160mg / hnub) tau pom tias yuav txo qis testosterone kom muaj kev cuam tshuam ntawm castrate ntau ntau hauv cov txiv neej nrog kev tswj hwm ib zaug ib hnub. Kev noj tshuaj qis dua (10–40mg / hnub) tseem tab tom kawm hauv kev kho mob ntawm endometriosis thiab uterine leiomyoma kom ua tiav ib feem ntawm kev sib deev hormone tawm. Qhov laj thawj tom qab ib nrab kev tsuj rau cov mob no yog kom txo qhov tshwm sim thiab qhov mob ntawm cov tsos mob ntawm lub cev lawm xws li kub lub cev thiab kom tsis txhob muaj pob txha ntxhia hloov pauv los ntawm cov tshuaj estrogen uas tuaj yeem ua rau txha.
Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!
Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.
Cim npe nrov: relugolix cas 737789-87-6, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag
