Ribociclib CAS 1211441-98-3

Khoom Qhia:

Cov Khoom Npe: Ribociclib CAS TSIS: 1211441-98-3

Txhais:

7-cyclopentyl-N, N-dimethyl-2 - ((5- (piperazin-1-yl) pyridin-2-yl) amino) -7H-pyrrolo [2,3-d] pyrimidine-6-carboxamide;

LEE 011;

Tshuaj& Cov Khoom Uas Lub Cev:

Zog: Dawb kom dawb-dawb hmoov

Ntsuas: ≥99.0%

Qhov ceev: 1.39g / cm3

Lub Ntsiab Kub: 730.8 ℃ ntawm 760 mmHg

Flash Point: 395.8 ℃

Solubility: Soluble hauv DMSO, tsis yog soluble hauv dej.

Cov lus piav qhia: Ribociclib Lub Hauv Paus Dawb, tseem hu ua LEE011, yog qhov ncauj muaj nyob rau ntawm lub zos kinase (CDK) cov kev txwv tsis pub muaj lub hom phiaj rau cyclin D1 / CDK4 thiab cyclin D3 / CDK6 lub voj voog ntawm tes, uas muaj peev xwm ua cov tshuaj tiv thaiv antineoplastic. CDK4 / 6 inhibitor LEE011 tshwj xeeb inhibits CDK4 thiab 6, yog li inhibiting retinoblastoma (Rb) protein phosphorylation. Kev txwv tsis pub cov Rb phosphorylation tiv thaiv CDK-mediated G1-S theem hloov, yog li ntes lub voj voog ntawm tes hauv G1 theem, txwv tsis pub DNA synthesis thiab inhibiting kev loj hlob ntawm tes mob hlwb Kev kho mob ntau dhau ntawm CDK4 / 6, raws li pom muaj qee yam mob qog noj ntshav, ua rau lub voj voos tawm ntawm tes.

Yam CAS #

1211441-98-3 (Ribociclib free puag)

1211443-80-9 (Ribociclib hydrochloride)

1374639-75-4 (Ribociclib succinate)

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

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Cim npe nrov: ribociclib cas 1211441-98-3, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

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