Ramelteon CAS 196597-26-9

Khoom Piav Qhia

Khoom npe: Ramelteon CAS 196597-26-9

Txhais:

N- [2 - [(8 S) -2, 6, 7, 8 - tetrahydro - 1 H-cyclopenta [e] [{ {9}}] benzofuran - 8 - yl] ethyl] propanamide

[14 C] -Ramelteon;

(S) -N- [2 - (1, 6, {{{9-}}}}, 8-tetrahydro-2H-indeno [5, 4-b] furan-8-yl) ethyl] propionamide;

Propanamide, N- [2 - [(8 S) -1, 6, {{5},, 8 - tetrahydro-2H-indeno [{{9 }}, 4-b] furan - 8 - yl] ethyl] -;

Ramelteon;

Rozerem;

TAK-375;

Tshuaj& Lub cev nqaij daim tawv

Zog: Dawb rau off-dawb Khoom

Ntsuas: ≥ 99. 0%

Ntom: 1. 1 g / cm 3

Lub Hauv Boiling Point: 455. 3 ℃ ntawm 760 mmHg

Melting Point: 113-115 ℃

Flash Point: 229. 2 ℃

Ramelteon, ua lag luam raws li Rozerem los ntawm Takeda Pharmaceuticals North America, yog tus neeg sawv cev pw tsaug zog uas xaiv khi rau MT 1 thiab MT 2 receptors hauv lub suprachiasmatic nucleus (SCN), tsis txhob khi rau GABAA receptors, xws li raws li nrog cov tshuaj zoo ib yam li zolpidem.

Txawm li cas los xij nws tsis tshwm sim los ua kom qhov pib ntawm kev pw tsaug zog lossis qhov ntau npaum li cas kev tsaug zog. Nws tau pom zoo los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj (FDA) rau siv ntev.

Ramelteon tsis qhia tias muaj kev lees paub qhov khi rau GABAA receptors, uas cuam tshuam nrog anxiolytic, myorelaxant, thiab amnesic cuam tshuam.

Ramitelon, lub npe lag luam: rozerem, lub npe tshuaj (S) -N - [2 - (1, 6, {{{{9 9}}}, 8-tetrahydro- { {17}} H-indeno [5, 4-b] furan-8-yl) ethyl] propionamide, pom zoo los ntawm FDA tau teev rau hauv Tebchaws Asmeskas thaum Lub Cuaj Hli 2 00 {{9} }, lag luam lub npe: rozerem, tuaj yeem siv rau kev kho mob ntawm insomnia ntawm nyuaj pw tsaug zog hom, thiab muaj cov ntsiab lus zoo rau mob ntev insomnia thiab insomnia luv. Cov khoom no tuaj yeem xaiv hom melatonin hom 1 receptor thiab hom {{1 5}} receptor (MT 1, MT 2), nce qeeb yoj pw tsaug zog (SWS) thiab ceev ceev qhov muag txav pw tsaug zog (rew), thiaj li txo qis insomnia.

Rimetidine yog thawj qhov tsis quav tshuaj insomnia kho mob tsis muaj npe raws li kev tswj tshwj xeeb. Tus txheej txheem ntawm kev ua yog tias rimetidine yog tshuaj lom neeg Phau ntawv agonist ntawm melatonin receptor, uas muaj qhov sib thooj siab siab nrog MT 1 thiab MT 2 receptors ntawm melatonin. Tsis tas li ntawd, nws tsis khi rau cov neurotransmitter receptors xws li GABA receptor complex, thiab tsis cuam tshuam cov kev ua haujlwm ntawm cov enzymes feem ntau hauv qee qhov kev kawm. Yog li, nws tuaj yeem zam qhov kev cuam tshuam uas cuam tshuam nrog GABA tshuaj (uas yuav ua rau muaj tsheb sib tsoo, ntog thiab pob txha), kev quav yeeb tshuaj thiab kev vam khom. Tag nrho cov nyiaj ntawm nws cov ntsiab metabolite M-II yog 20-100 npaug ntawm niam, tab sis nws cov haujlwm tseem tsawg. Nws qhov sib cuam tshuam nrog MT 1 thiab MT 2 receptors yog hais txog 1 / 5 thiab 1 / 10 ntawm tus niam, feem. Piv nrog rau cov tshuaj qub, nws cov tshuaj pharmacological tau txo los ntawm 17-25 zaug. Lwm cov khoom siv ua pa tawm ntawm cov khoom no tsis muaj kev ua ub no.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov hu rau peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: ramelteon cas 196597-26-9, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

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