JDTic. 2 HCl CAS 785835-79 - 2

Khoom Piav Qhia

Khoom npe: JDTic. 2 HCl CAS 785835-79 - 2

Txhais:

(3 R) -7-hydroxy-N - [({4}} S) -1 - [(3 R, 4 R) - {{ 7}} - (3 - hydroxyphenyl) - 3, 4 - dimethylpiperidin-1-yl] - 3 - methylbutan - {{4}} -yl] -1, {{4}},, 3, 4 - tetrahydroisoquinoline - 3 - carboxamide dihydrochloride;

JDTic dihydrochloride;

(3 R) -7-hydroxy-N - [({4}} S) - {{4}} - {[(3 R, { {7}} R) - 4 - (3 - hydroxyphenyl) - 3, 4 - dimethyl - {{4}} - piperidinyl] methyl } - 2 - methylpropyl] - {{4,}, 2, 3, 4 - tetrahydro - 3 - isoquinolinecarboxamide;

1, {{1}}, 3, 4 - tetrahydro-7-hydroxy-N - [(1 S) - {{0} } - [[(3 R, 4 R) - 4 - (3 - hydroxyphenyl) - 3, 4 - dimethyl- 1 - piperidinyl] methyl] - {{1}} - methylpropyl] - (3 R) -isoquinolinecarboxamide;

Tshuaj& Lub cev nqaij daim tawv

Zog: Dawb rau off-dawb Khoom

Ntsuas: ≥ 99. 0%

Hauv Vivo:

JDTic (2. 5 - 1 6 mg / kg, sc) koob tshuaj-tiv thaiv kev txiav txim siab cov lus teb ntawm nicotine hauv qhov sim-tw tawm tab sis tsis muaj dab tsi cuam tshuam rau qhov kub-phaj soj lossis qhov kub ntawm lub cev cov kev ntsuas ntawm txhua qhov tshuaj ntsuas hauv cov nas txhaj muaj nicotine [1]. JDTic (3 mg / kg, ip) muaj peev xwm thim qhov kev ntxhov siab zoo li tus cwj pwm hauv nas qauv ntawm kev ntxhov siab hangover. JDTic (1 0 mg / kg, ip) txo kev haus cawv rau tus kheej kev tswj hwm, txwv tsis pub haus cawv rov qab los nrhiav kev haus cawv, thiab tshwj xeeb txwv qhov cuam tshuam ntawm KOR agonist ntawm 2 h lub sij hawm sib deev ua ntej taw tes [ 2]. JDTic ({{1 3}} mg / kg, ig) ho tseem ceeb U U 50, 488-hle diuresis tam sim hauv nas [3].

Cov thawj coj tsiaj:

Cov nas: Cov nas tsuag uas hno yog txhaj nrog JDTic (1, 4, {{2}}, lossis 1 6 mg / kg) 1 {{ 12}} h ua ntej tso tawm cov nicotine (2. 5 mg / kg, sc). Vim JDTic lub sijhawm ntev heev ntawm kev nqis tes ua, 1 8-h preinjection tau xaiv rau kev tshawb fawb. Antinociception siv tus tw-flick thiab kub-phaj ntsuas yog ntsuas 5 min tom qab kev txhaj tshuaj nicotine lossis 2 0 feeb tom qab morphine (8 mg / kg, sc), thiab cov kev hloov hauv lub cev kub raug ntsuas 30 min tom qab txhaj. Txhawm rau kom paub tseeb tias tsis muaj mu cov kev cuam tshuam los ntawm JDTic hauv cov kev tshawb fawb no, JDTic (1 6 mg / kg) tseem tau txais kev tswj 1, 6, 1 8, thiab { {5}} 4 h ua ntej morphine (8 mg / kg, sc) hauv kev sim ntsuas tus Tsov tus tw, thiab qhov tshuaj tiv thaiv kev tiv thaiv yog ntsuas 2 0 min tom qab morphine.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: 2 hcl cas 785835-79 - 2, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: Ramelteon CAS 196597-26-9
• Tom ntej: IRAK Tus Neeg Tso Cai Kev Tso Npe 6 CAS 1042672-97-8