Midostaurin CAS 120685-11-2

Product Description:

Khoom npe: Midostaurin CAS NO: 120685-11-2

Synonyms:

4'-N-benzoylstaurosporine;

PKC412,9S-(9 ,10 ,11 ,13 )-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo1,2,3-gh:3',2',1'-lmpyrrolo3,4-j1,7benzodiazonin-11-yl)-N-methylbenzamide;

Cgp 41 251;

Chemical Physical Properties:

Cov tsos: Tan solid

Assay: Ntau dua lossis sib npaug rau 99.0 feem pua

Qhov ceev: 1.46g / cm3

Refractive Index: 1.76

Cia txias: Khaws ntawm 2-8 degree

Solubility: Soluble hauv DMSO (15 mg / ml), MDC (10 mg / ml), methanol (5 mg / ml), 100% ethanol (2.5 mg / ml), thiab DMF (20 mg / ml).

Cov ntaub ntawv kev nyab xeeb:

Kev nyab xeeb Code: T

Cov nqe lus pheej hmoo: R36/37/38

HS Code: 29329990

Midostaurin (PKC412) yog ib qho multi-lub hom phiaj protein kinase inhibitor raug soj ntsuam rau kev kho mob ntawm myeloid leukemia (AML) thiab myelodysplastic syndrome (MDS). Nws yog ib nrab -synthetic derivative ntawm staurosporine, ib qho alkaloid los ntawm cov kab mob Streptomyces staurosporeus, thiab ua haujlwm rau cov neeg mob uas muaj kev hloov pauv ntawm CD135 (FMS-zoo li tyrosine kinase 3 receptor, FLT3).

Tom qab kev sim tshuaj Phase II ua tiav, Phase III sim rau AML tau pib xyoo 2008. Nws tab tom sim tshuaj midostaurin ua ke nrog daunorubicin thiab cytarabine. Hauv lwm qhov kev sim, cov tshuaj tau pom tias tsis muaj txiaj ntsig hauv metastatic melanoma.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom raws li patent yog muab rau RD lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: Midostaurin CAS 120685-11-2, tuam ntxhab, lwm tus muag khoom, Hoobkas, yuav, hauv Tshuag

• Tug: Plitidepsin CAS 137219-37-5
• Tom ntej: Illudin S CAS 1149-99-1