EW-7197 CAS 1352608-82-2

Khoom Piav Qhia:

Khoom Lub Npe: EW-7197 CAS TSIS TAU: 1352608-82-2

Lub ntsiab lus:

1H-Imidazole-2-methanamine, N- (2-fluorophenyl) -5- (6-methyl-2-pyridinyl) -4- [1,2,4] triazolo [1,5-a] pyridin-6-yl -;

Vactosertib (EW-7197;

CS-2287;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Crystalline khoom

Kev Ntsuas: ≥98.0%

Ceev: 1.40 ± 0.1 g/cm3 (Kwv yees)

PKa: 8.51 ± 0.10 (kwv yees)

Index ntawm Refraction: 1.725

EW-7197 yog qhov tshiab ALK-5 kinase inhibitor ntxiv rau TGF-β Hom I Receptor Kinase Inhibitor. Txoj kev tshawb fawb tau qhia tias nws tuaj yeem tiv thaiv lub mis kom mob ntsws metastasis. Kev tshawb fawb nas tau pom tias EW-7197 txwv tsis pub Smad/TGFβ teeb liab, hloov chaw ntawm tes, txav mus los, thiab mob ntsws metastasis hauv MMTV/c-Neu nas thiab 4T1 orthotopic-grafted nas. EW-7197 kuj tseem txwv tsis pub hloov pauv epithelial-to-mesenchymal (EMT) hauv ob qho tib si TGF-kho cov qog nqaij hlav qog noj ntshav thiab 4T1 cov kab mob orthotopic-grafted. Tsis tas li ntawd, EW-7197 txhim kho cytotoxic T lymphocyte kev ua haujlwm hauv 4T1 orthotopic-grafted nas thiab nce lub sijhawm muaj sia nyob ntawm 4T1-Luc thiab 4T1 lub mis mob qog noj ntshav. Nws tseem tuaj yeem tiv thaiv kab mob siab, lub raum, thiab mob ntsws los ntawm kev thaiv TGF-β/Smad thiab ROS teeb liab. Yog li, nws yog qhov muaj peev xwm antitumor reagent.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: ew-7197 cas 1352608-82-2, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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