BLU9931 CAS 1538604-68-0

Khoom Piav Qhia:

Khoom Lub Npe: BLU9931 CAS TSIS TAU: 1538604-68-0

Lub ntsiab lus:

2-Propenamide, N- [2-[[6- (2,6-dichloro-3,5-dimethoxyphenyl) -2-quinazolinyl] amino] -3-methylphenyl]-;

LM-3610;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Khoom los yog hmoov

Kev Ntsuas: ≥98.0%

Ceev: 1.361 ± 0.06 g/cm3 (Kwv yees)

PKa: 13.15 ± 0.70 (kwv yees)

Index ntawm Refraction: 1.677

BLU9931 yog lub zog, xaiv tau, thiab hloov tsis tau FGFR4 inhibitor nrog IC50 ntawm 3 nM thiab xaiv tau ntawm 297,184 thiab 50 zaug siab dua rau FGFR1/2/3, feem. Hauv MDA-MB-453 cov hlwb, BLU9931 ua rau muaj txiaj ntsig zoo tiv thaiv phosphorylation ntawm FGFR4 teeb tsa txoj hauv kev. Blu9931 txwv tsis pub nthuav tawm HCC xovtooj ntawm kab, xws li Hep3B, Huh-7, Chemicalbook, thiab JHH-7, qhia txog qhov ua tsis tau zoo FGFR4 teeb liab nrog EC50< 1="" μm.="" blu9931="" tseem="" tiv="" thaiv="" kev="" nthuav="" dav="" hauv="" pdx-muab="" cov="" kab="" xovtooj="" ntawm="" tes="" nrog="" fgfr4="" teeb="" tsa="" txoj="" hauv="" kev.="" hauv="" cov="" nas="" uas="" muaj="" fgf19-nthuav="" dav="" hep3b="" qog="" nqaij="" hlav,="" blu9931="" (300mg/kg,="" po)="" ua="" rau="" cov="" qog="" puas="" thiab="" tiv="" thaiv="" kom="" cov="" qog="" poob="" phaus.="" blu9931="" (300mg/kg,="" po)="" kev="" kho="" mob="" kuj="" tseem="" ua="" rau="" cov="" qog="" ua="" haujlwm="" tsis="" zoo="" nyob="" hauv="" phau="" ntawv="" tshuaj="" ntshav="" tau="" ntim="" cov="" nas="" nrog="" fgf19-="" kev="" tshaj="" tawm="" ntawm="" pdx-tau="" txais="" lixc012="">

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: blu9931 cas 1538604-68-0, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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