AZD-4635 CAS 1321514-06-0

Khoom Piav Qhia:

Khoom Lub Npe: AZD-4635 CAS TSIS TAU: 1321514-06-0

Lub ntsiab lus:

HTL-1071;

1,2,4-Triazin-3-amine, 6- (2-chloro-6-methyl-4-pyridinyl) -5- (4-fluorophenyl)-;

6- (2-chloro-6-methylpyridin-4-yl) -5- (4-fluorophenyl) -1,2,4-triazin-3-amine;

Tshuaj& Lub Cev Muaj Zog:

Tshwm sim: Khoom los yog hmoov

Kev Ntsuas: ≥99.0%

Kub Point: 491.5 ± 55.0 ℃ (Kwv yees)

Ceev: 1.387 ± 0.06 g/cm3 (Kwv yees)

PKa: 1.75 ± 0.63 (Kwv yees)

Imaradenant (AZD4635, HTL1071) yog qhov ncauj A2AR antagonist uas tuaj yeem khi rau tib neeg A2AR nrog Ki tus nqi ntawm 1.7 nM, uas yog ntau dua 30 lub sijhawm xaiv ntau dua rau A2AR dua li lwm cov adenosine receptors. Hauv CHO hlwb ruaj khov qhia tib neeg A2AR, AZD4625 txwv tsis pub tsim cAMP nrog IC50 qhov tseem ceeb ntawm 0.79, 10.0 thiab 142.9 nM thaum muaj 0.1, 1 thiab 10 μmadenosine, feem. Kev txwv tsis pub siv A2AR los ntawm AZD4625 tuaj yeem txo cov qog nqaij hlav thiab txhim kho kev tiv thaiv qog nqaij hlav.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: azd-4635 cas 1321514-06-0, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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