Zelgen Biopharmaceuticals Obeticholate Magnesium ntsiav tshuaj Tau Txais Tshuaj Ntsuam Xyuas Kev Pom Zoo Ncaj Ncees

Thaum Lub Kaum Ib Hlis 18, Suzhou Zelgen Biopharmaceuticals Co., Ltd tau tshaj tawm hais tias lub tuam txhab tsis ntev los no tau txais" Daim Ntawv Ceeb Toom Kev Tshuaj Ntsuam Xyuas Pom Zoo Tshuaj" pom zoo thiab xa tawm los ntawm Lub Xeev Lub Chaw Saib Xyuas Khoom Noj thiab Tshuaj. Lub sijhawm no, nws raug pom zoo ua tiav Phase I / II thiab Theem III kev soj ntsuam kuaj pom ntawm magnesium obeticholate ntsiav tshuaj rau kev kho mob thawj biliary cholangitis (PBC) thiab tsis muaj cawv steatohepatitis (NASH). Magnesium obeticholate yog chav kawm 2.1 cov tshuaj tshiab, thiab nws yog kev hloov kho tshiab cov tshuaj tshiab ntawm cov ntsev thiab cov qauv siv lead ua ntawm obeticholic acid uas tau muag hauv Tebchaws Europe thiab Tebchaws Asmeskas.

Daim ntawv tshaj tawm qhia tias cov tshuaj magnesium obeticholate yog hom 2.1-tshuaj tshiab ywj siab tsim los ntawm lub tuam txhab, thiab yog cov tshuaj tshiab txhim kho uas yog hloov kho cov ntsev thiab cov qauv siv lead ua ntawm obeticholic acid uas tau muag hauv Tebchaws Europe thiab Tebchaws Asmeskas. Magnesium obeticholate yog farnesol X receptor agonist, uas tsis tsuas tuaj yeem tswj cov metabolism ntawm cov roj lipoprotein thiab cov kua tsib cov kua qaub (BAs), tab sis kuj tseem txhim kho kev tiv thaiv kab mob thiab fibrosis. Yog li no, magnesium obeticholate vam tias yuav tsim los kho tus mob chilangitis (PBC), tsis muaj cawv steatohepatitis (NASH), tsis muaj dej cawv lossis mob siab ua rau lub siab (NAFLD), mob qog, thiab thawj sclerosing bile ducts Inflammation (PSC) thiab lwm yam tshuaj.

Tus thawj tshuaj,obeticholic acid,tau pom zoo los ntawm Asmeskas FDA thiab European Commission kev kho tus mob cholangitis (PBC) thaum Lub Rau Hli thiab Kaum Ob Hlis 2016, ua kom tiav. Raws li kev tshaj tawm ntawm obeticholic acid cov chaw tsim tshuaj paus Kev cuam tshuam Raws li cov ntaub ntawv pej xeem, muag ntawm obeticholic acid nyob hauv European thiab Asmeskas kev lag luam hauv 2019 yog $ 249.6 lab, thiab cov muag hauv European thiab Asmeskas kev lag luam hauv thawj peb lub hlis twg ntawm 2020 yog Teb Chaws Asmeskas $ 229.4 lab. Txog tam sim no, obeticholic acid tsis tau muaj npe nyob hauv Suav teb.