Tebchaws Askiv Pom Zoo Qhov Taw Qhia Thib Peb Ntawm Epidyolex: Kev Kho Mob Tub Rog Sclerosis (TSC) cuam tshuam txog kev mob vwm!

GW Pharma, lub hauv paus ntawm Jazz Pharmaceuticals, yog tus thawj coj thoob ntiaj teb hauv kev tshawb fawb thiab kev txhim kho ntawm cov khoom cog los ntawm cannabinoid kho tshuaj. Nws tau mob siab rau nrhiav pom, tsim kho thiab ua lag luam cov tshuaj kho tshiab los ntawm cannabis. Tsis ntev los no, GW Pharma tshaj tawm tias Cov Tshuaj thiab Kev Tswj Xyuas Khoom Noj Qab Haus Huv (MHRA) ntawm Tebchaws Askiv tau pom zoo qhov kev qhia tshiab rau Epidyolex (cannabidiol, CBD) kev npaj ua kua hauv qhov ncauj: raws li kev kho mob ntxiv rau cov neeg mob ≥2 xyoos. Kev qaug dab peg txuam nrog tuberous sclerosis syndrome (TSC).

MHRA kev pom zoo siv rau Askiv, Wales thiab Scotland. Nws tau kwv yees tias muaj 3700-11,000 TSC cov neeg mob hauv tebchaws Askiv. TSC tuaj yeem ua rau txog 85% ntawm cov neeg mob txhawm rau mob vwm, thiab txog li 60% ntawm lawv tsis teb rau cov tshuaj tiv thaiv tus mob vwm. MHRA' kev pom zoo ntawm Epidyolex TSC qhov qhia yog qhov kev nce qib tseem ceeb rau TSC cov neeg mob hauv tebchaws Askiv, ntau tus neeg yuav muaj peev xwm tau txais txiaj ntsig los ntawm txoj kev kho tshiab no.

GW thaum pib tau txais kev tso cai ua lag luam Epidylex hauv tebchaws Askiv thaum lub Cuaj Hlis 2019: rau cov neeg mob ≥ 2 xyoos, kev kho mob ntxiv ntawm qaug dab peg cuam tshuam nrog Lennox-Gastaut syndrome (LGS) thiab Dravet syndrome (DS). Qhov kev pom zoo TSC no qhia txog plaub qhov kev pom zoo tshuaj cannabinoid rau GW hauv tebchaws Askiv.

Thaum Lub Ob Hlis xyoo no, Jazz Pharma tshaj tawm kev yuav GW Pharma rau US $ 7.2 nphom. Qhov no yog qhov tau txais ntau tshaj plaws hauv kev lag luam cannabis txog tam sim no thiab qhov tseem ceeb txav mus rau Jazz kom nkag mus rau cannabinoid chaw ua tshuaj. Tom qab kev sib koom ua ke, Jazz yuav dhau los ua tus thawj coj hauv thaj chaw ntawm neuroscience.

Epidyolex/Epidiolex yog thawj tsob nroj cog los ntawm cannabinoid tshuaj pom zoo rau kev kho tus mob vwm nyob hauv Tebchaws Meskas thiab Europe. Cov tshuaj no yog qhov ncauj, ua kua ua kom muaj cov ntshiab huv CBD rho tawm. CBD yog cov khoom tsis muaj kev puas siab ntsws tau muab los ntawm tsob ntoo hemp thiab muaj ntau yam tshuaj muaj txiaj ntsig ntawm lub paj hlwb. Muaj ntau qhov kev tshawb fawb tau qhia tias CBD muaj cov tshuaj tiv thaiv kab mob vwm thiab tiv thaiv kev ua kom tsis muaj zog, thiab muaj cov kev mob tshwm sim tsawg dua li cov tshuaj tiv thaiv kab mob vwm tam sim no.

Hauv Tebchaws Meskas, Epidiolex tau txais kev pom zoo rau 3 qhov qhia: rau cov neeg mob ≥ 1 xyoos, kev kho tus mob qaug dab peg ntsig txog LGS, DS, thiab TSC. Hauv Tebchaws Europe, Epidyolex kuj tseem tau pom zoo rau 3 qhov qhia: (1) raws li kev kho mob ntxiv rau cov neeg mob ≥2 xyoos rau kev kho mob qaug dab peg cuam tshuam nrog TSC; (2) ua tshuaj ntxiv nrog clobazam, Siv rau cov neeg mob ≥ 2 xyoos los kho qaug dab peg ntsig txog LGS thiab DS. Hauv Tebchaws Meskas thiab European Union, Epidylex/Epidiolex tau txais kev tso cai tshuaj menyuam ntsuag rau kev kho DS, LGS, thiab TSC ntsig txog qaug dab peg. Txhua tus kab mob yog qhov tsis tshua muaj, mob hnyav, thiab thaum menyuam yaus pib siv tshuaj-ua kom tsis zoo ntawm tus mob vwm.

TSC yog ib yam kab mob tsis tshua muaj thiab loj uas tshwm sim thaum tseem me. Epilepsy yog qhov ua rau lub paj hlwb feem ntau ntawm TSC. TSC tuaj yeem ua rau qaug dab peg txog li 85% ntawm cov neeg mob, thiab ntau npaum li 60% ntawm cov neeg mob tsis teb rau cov tshuaj tiv thaiv kab mob txheem thiab ua rau qaug dab peg tshuaj. Muaj qhov xav tau tseem ceeb rau kev kho tshiab hauv kev hais daws qaug dab peg cuam tshuam nrog TSC. Cov ntaub ntawv los ntawm theem III kev tshawb fawb qhia pom tias piv nrog cov placebo, Epidiolex txo qis TSC cuam tshuam txog kev qaug dab peg (suav nrog focal thiab dav dav) thiab txhim kho tag nrho cov neeg mob. Epidyolex/Epidiolex yuav muab qhov kev kho mob tseem ceeb rau cov neeg mob TSC.