Novo Nordisk Yuav Pib Ua Qhov Piv Txwv Theem 3a Kev Kuaj Txog Ntawm Qhov Ncauj Ntawm Smeglutide

Novo Nordisk tshaj tawm tias nws npaj yuav pib ua piv txwv Theem 3a soj ntsuam kev sim ntawm 2.4 mg qhov ncauj GLP-1 agonist semaglutide txhawm rau tshawb kev rog (BMI ≥ 30 kg / m2) lossis Kev Kho Mob rau cov neeg laus uas nyhav dhau los (BMI≥27kg / m2) thiab muaj tsawg kawg ib qho hnyav sib xws ntsig txog kev hnyav.

Nrog kev txhim kho ntawm cov neeg' s txoj kev ua neej nyob, kev rog tau dhau los ua lub ntiaj teb kev noj qab haus huv cov teeb meem. Raws li kev txheeb cais, kwv yees li 650 lab tus neeg laus thoob ntiaj teb raug kev rog. Tus neeg tua neeg no tso lub nra hnyav rau lub cev thiab tuaj yeem ua rau muaj kev cuam tshuam txog teeb meem xws li ntshav qab zib hom 2, kab mob plawv, pw tsaug zog tsis tsaug zog, tsis mob cawv rog thiab mob qog nqaij hlav. Tsis tas li ntawd xwb, kev rog dhau rog tuaj yeem ua rau muaj kev pheej hmoo mob hnyav thiab pw hauv tsev kho mob vim yog KEVID-19.

Semaglutide (semaglutide) yog tib neeg glucagon zoo li peptide-1 (GLP-1) analog, uas txhawb cov tshuaj insulin zais thiab txwv tsis pub glucagon tso pa tawm los ntawm cov kua nplaum concentration-dependant mechanism, uas tuaj yeem ua rau hom 2 mob ntshav qab zib mellitus tus neeg mob' s ntshav qab zib cov qib tau zoo tuaj thiab muaj kev pheej hmoo txo ​​ntshav qab zib tsawg tsawg. Ntxiv rau, semaglutide kuj tseem tuaj yeem pab tib neeg noj tsawg dua, txo cov calories kom tsawg, thiab ua rau poob phaus los ntawm kev txo kev tshaib plab thiab nce satiety.

Tam sim no, Novo Nordisk tau tsim qhov kev npaj txhaj tshuaj (Ozempic) thiab kev npaj ntawm qhov ncauj (Rybelsus) rau semaglutide.

Kev npaj kev txhaj tshuaj (Ozempic)

Lub npe lag luam ntawm smeglutide txhaj tshuaj yog Ozempic. Lub Rau Hli xyoo tas los, Novo Nordisk tshaj tawm cov ntsiab lus saum toj kawg nkaus ntawm ob lub sijhawm kawg Theem IIIa kev kuaj mob (STEP 2, STEP 3) hauv qhov project Phase III STEP rau qhov hnyav-poob ntawm kev txhaj tshuaj smegaglutide (Ozempic) Qhov kev sim tau nrhiav 4,500 cov neeg rog rog lossis rog dhau, thiab txoj kev tshawb nrhiav pom tias cov neeg mob uas tau txhaj tshuaj semaglutide qhia txog qhov hnyav poob ntawm 16-18%.

Kev npaj ntawm lub qhov ncauj (Rybelsus)

Rybelsus yog lub npe lag luam ntawm lub qhov ncauj smeglutide, thawj qhov ncauj GLP-1 receptor agonist tshuaj (GLP-1RA) pom zoo los ntawm FDA. Nws qhov tshwm sim tawg tus qauv ntawm txhua hnub lossis txhua lub limtiam GLP-1RA kev txhaj tshuaj rau cov neeg mob ntshav qab zib hom 2, thiab muab cov kev kho mob uas tsis muaj kev tiv thaiv zoo rau cov ntshav qab zib. Hauv Tebchaws Meskas, European Union thiab Nyij Pooj, kev tswj hwm qhov ncauj ntawm 7 mg lossis 14 mg Rybelsus tau pom zoo ua cov tshuaj noj rau kev noj haus thiab kev tawm dag zog txhawm rau txhim kho cov ntshav qab zib kom tswj tau hauv cov neeg muaj ntshav qab zib hom 2.

Nws tau tshaj tawm tias 68 lub lis piam mus sib hais hauv ntiaj teb tau npaj rau xyoo no yuav pib nyob rau lub sijhawm thib ob ntawm lub xyoo, thiab npaj yuav nrhiav 1,000 tus neeg rog rog lossis cov neeg mob nyhav dua qub nrog rau kev kuaj mob kom ua tau zoo thiab muaj txiaj ntsig ntawm qhov ncauj ntawm qhov ncauj. kev nyab xeeb.

Nws xav tias qhov ncauj semaglutide tuaj yeem nqa xov xwm zoo rau cov neeg mob rog.