Xwm: Lom Zem! Nyias Hlau Membrane Xa Tawm Tsheb T-Mob Hlav Tau yooj yim rau hauv cov khoom ua kom lub pob

Yuav ua li cas yog tias cov hlau twb siv los kho pob txha lov, ncaj hniav thiab tiv thaiv cov hlab ntshav txhaws kuj tseem siv tau los txwv kev mob qog noj ntshav?

Hauv txoj kev tshawb nrhiav tshiab, cov kws tshawb nrhiav los ntawm Fred hutchinson kev tshawb nrhiav kab mob qog nqaij hlav hauv Tebchaws Meskas tau pom tias thawj zaug tias cov kabmob me me thiab cov menyuam mos qog ua haujlwm nrog cov kabmob tiv thaiv kabmob tuaj yeem ua rau cov mob qog nqaij hlav cancer tsis muaj mob. Cov txiaj ntsig tau nyuam qhuav luam tawm nyob rau hauv Nature Biomedical Engineering nyob rau hauv lub npe "Nitinol nyias zaj duab xis ua haujlwm nrog lub tsheb-t rau lub hlwb rau kev kho cov qog ua pob."

Cov duab los ntawm Fred Hutchinson Cancer Research Center

Matthias Stephan, tus kws tshawb fawb ntawm Fred hutchinson lub chaw tshawb nrhiav kabmob cancer thiab tus kws sau ntawv tau hais tias, "kev kho cell los tua mob qog noj ntshav tau zoo heev rau cov ntshav qog ntshav, tab sis tsis yog cov qog. nyias daim phiaj hlau thauj khoom nrog lub cev tsim cov t-cell los tiv thaiv qog ntawm zes qe menyuam muaj peev xwm tshem tawm cov qog hlav hauv 70 feem pua ntawm cov nas kho, muab peb ua cov kauj ruam tseem ceeb ua kev kho cell zoo tiv thaiv qog hlav. "

Cov qog ua kom tawv nqaij, suav nrog lub mis, mob ntawm zes qe menyuam thiab mob qog nqaij hlav, muaj ntau lub tswv yim txhawm rau tiv thaiv thiab rov qab tiv thaiv cov kab mob qog ntshav uas tua cov mob qog nqaij hlav, xws li T cell, lossis qog nqaij hlav hauv lub cev, uas qhia txog chimeric antigen receptor (CAR). -nyob rau hauv hlwb ib leeg yuav tsis ua haujlwm; Lawv yuav kis tsis tau cov qog, lossis yog tias lawv kis rau cov kabmob kheesxaws, lawv nkees sim tua cov qog nqaij hlav cancer thiab poob mus.

Stephan tau tsim cov khoom siv uas muaj kev nyab xeeb rau tib neeg thiab tuaj yeem nqa cov qog nqaij hlav cancer rau hauv cov qog. "Ntxiv rau kev txo cov kev mob tshwm sim rau cov neeg mob, peb lub hom phiaj kawg yog ua kom t-cell kho sai dua, pheej yig dua thiab yooj yim xa mus rau cov neeg mob, "nws hais.

Ua kom tiav qhov no, Stephan txoj kev tshawb nrhiav tshiab thauj cov t-t cell lub hom phiaj mob cancer ntawm zes qe menyuam mus rau cov ntxaij hlau ntawm cov leeg nqaij, uas tau muab tso rau ntawm cov qog.

"Nws tsis yog cov khoom siv dhau los xa khoom. Nws tseem yog lub chaw tso tawm rau kev ua kom loj hlob ntawm lub tsheb-t cell, uas tuaj yeem kov yeej cov kabmob tiv thaiv tawm tsam cov T cell no."

Cov kws tshawb nrhiav tau siv cov ntawv sib txawv, yuav luag pom cov hlau ua los ntawm Monarch Biosciences. Cov yeeb yaj kiab hlau, uas yog 10 microns tuab thiab ua los ntawm Nitinol alloy, tuaj yeem muab cov khoom ntub rau hauv lub cev thiab siv tau rau hauv lwm cov khoom siv kho mob.

Hauv qab lub tshuab tsom iav haib, cov zaj duab xis hlau muaj qhov Chaw Me me uas tuaj yeem tsim kho mus rau hauv cov qauv sib txawv. Qhov chaw no tau ntim nrog tshuaj lossis lwm yam kua, thiab cov qog hlau tuaj yeem nkag mus rau hauv lub cev, qhov chaw uas cov kua dej tawm hauv thiab nrhiav lawv lub hom phiaj.

Stephan thiab nws cov npoj yaig xav pom tias lub npov hlau puas tuaj yeem muaj T cell thiab xa cov hlwb tua cov qog nqaij hlav mus rau qog hlav.

"Peb yuav tsum nrhiav qhov chaw sib txawv ntawm cov xim hlau uas haum rau cov t-cells. Cov qauv hauv qhov chaw yuav tsum me me kom tsis txhob cia lub hlwb poob ntawm qhov puas, tab sis tsis yog me me uas cov T hlwb xav tias muaj neeg coob dhau mus. . "

Lawv pom tias tus qauv kab, zoo ib yam li tus saib sab saum toj-hauv qab, zoo tshaj plaws rau T-hlwb. Lawv tau muab cov xim hlau ua ke nrog ntau cov ntaub ntawv, tso cai rau lub cev tsheb-t kom loj hlob thiab nce ib zaug hauv lub cev.

Cov kws tshawb nrhiav tau siv lub tshuab nqus hlau nrog lub tsheb t-qog uas tau tsim los nrhiav lub zes qe menyuam zes qe menyuam cov kabmob ROR1.These cov kws kho tsheb tau tso rau lub tsheb-tsheb tau muab tso rau ob sab ntawm cov xov hlau thiab tom qab ntawd nqus mus rau hauv nruab nrab ntawm cov khoom siv coated. Cov.

Stephan hais tias "Nws zoo li lub ncuav ci nrog cov kua txiv kab ntxwv ntawm ob sab," Stephan hais. Lub tshuab hlau no yog lub khob cij, thiab tom qab ntawd peb muab tso rau lub tsheb-t cov nqaij ntshiv ntawm ob sab ntawm nws, thiab cov roj ntsha no tau tso rau hauv nruab nrab. "

Siv lub chaw kuaj ntsuas tus kabmob kheesxaws ntawm zes qe menyuam, cov kws tshawb nrhiav cog ib daim ntawv tso rau hauv cov hlau uas muaj cov kab mob tso rau hauv lub qog. T qog tau tsiv tawm los ntawm cov qog hlau thiab metastasize mus rau qhov chaw ze ntawm cov qog. Tsis pub dhau 10 hnub, tag nrho cov qog hauv cov nas tau ploj lawm. Hauv 20 hnub, 70 feem pua ntawm cov nas tseem tsis tuaj yeem mob qog.

Yog tias pom tseeb los ntawm kev tshawb fawb ntau ntxiv thiab kev sim tshuaj, cov qauv txheej txheem ua kom cov qog hlau txhawm rau txhawm rau txhawm rau qog hlav hlav tuaj yeem siv los kho cov kab mob xws li mob pancreatic thiab mob qog qe menyuam.

Hauv lwm qhov kev sim, cov kws tshawb nrhiav pom tias cov leeg tub ua pa nrog lub cev ua kom cov leeg nqaij tiv thaiv qog los tiv thaiv qog los ntawm kev loj hlob mus rau hauv cov qog nqaij ntawd. Cov txheej txheem tuaj yeem siv los kho cov qog nqaij hlav uas ua rau muaj qhov ua pa ntawm txoj hlab pa lossis lub plab zom mov, xws li mob ntsws, mob hlab ntsha hlwb lossis txoj hlab pas, uas cov hlab ntsha yog siv los tua cov qog cuam tshuam nrog nqos.

"Peb tab tom tsom mus rau hauv lub cev-t cell hauv peb cov kev sim tam sim no, tab sis kuv tuaj yeem pom txoj kev ua no ua haujlwm nrog t-cell receptor kev kho mob, kev tua cov kab mob tua neeg thiab lwm yam kev tiv thaiv kabmob uas lub hom phiaj mob cancer," Stephan hais.

Siv ： 1.Michael E. Coon li al. Nitinol nyias zaj duab xis ua haujlwm nrog CAR-T hlwb rau kev kho cov qog ua haujlwm. Xwm Biomedical Engineering, 2019, doi: 10.1038 / s41551-019-0486-0.

2.Sistists qhia pom cov xaim npuag me me uas thau T cell ntsws cov qog

https://medicalxpress.com/news/2019-12-scientists-thin-metal-mesh-cells.html