Merck's Qhov ncauj tshuaj tiv thaiv kab mob Molnupiravir nkag mus rau Phase 3 Kev Kho Mob Kuaj Mob: Rau Kev Tiv Thaiv Tom Qab Kev Tiv Thaiv ntawm COVID-19!

Tsis ntev los no, Merck& Co thiab Ridgeback Biotherapeutics koom ua ke tshaj tawm tias lawv tau pib theem 3 MOVe-AHEAD (MK-4482-013, NCT04939428) kev sim tshuaj ntsuam xyuasmolnupiravir(MK-4482/EIDD-2801) rau kev tiv thaiv tom qab kis tau tus kab mob COVID-19. Txoj kev tshawb fawb thoob ntiaj teb no yuav tso npe rau cov neeg hnub nyoog 18 xyoo uas nyob hauv tib tsev neeg raws li kev kuaj pom-kuaj pom thiab tus tsos mob SARS-CoV-2 tus neeg mob.

Molnupiravir yog tshuaj tua kab mob hauv qhov ncauj, sib koom tsim los ntawm Merck thiab Ridgeback Biotherapeutics, rau kev kho mob ntawm COVID-19 thiab rau kev tiv thaiv tom qab kis tau tus kab mob COVID-19.

Dr Nick Kartsonis, Tus Lwm Thawj Coj ntawm Kev Tshawb Fawb Txog Kev Tshuaj Tiv Thaiv thiab Kab Mob Sib Kis ntawm Merck Research Laboratories, tau hais tias:&"; Nrog kev txhim kho txuas ntxiv ntawm COVID-19 muaj thoob qhov txhia chaw, ntau qhov hauv ntiaj teb tau tshaj tawm txog kev nce hauv sib kis mus. Peb yuav tsum kawm txoj hauv kev tshiab los tiv thaiv kev kis mob. Cov tib neeg uas vam khom tus kab mob no tau tiv thaiv los ntawm cov tsos mob. Yog ua tiav,molnupiravirxav tias yuav muab qhov kev xaiv tseem ceeb ntxiv los pab txo lub nra hnyav ntawm CVID-19 hauv zej zog."

Thaum ib nrab Lub Yim Hli xyoo no, ob tog tau tshaj tawm qhov pib xa tawm ntawm molnupiravir rau Kev Noj Qab Haus Huv Canada raws li kev kho kab mob tiv thaiv kab mob tau hais tawm ob zaug ib hnub rau qhov muaj peev xwm kho tau ntawm COVID-19. The Phase 2 cov txiaj ntsig ib ntus ntawm The Phase 2/3 MOVe-OUT kev sim tshuaj kho mob tau tshaj tawm ntawm European Conference on Clinical Microbiology and Infectious Diseases (ECCMID) thaum Lub Xya Hli xyoo no. Cov ntaub ntawv tau qhia tias ntawm cov neeg mob tsis nyob hauv tsev kho mob COVID-19 nrog cov tsos mob tsawg dua 5 hnub, Molnupiravir qhia tau zoo tshaj plaws.

Theem 3 ntu ntawm MOVe-OUT kev sim tseem tab tom ua, suav nrog hauv qee qhov chaw kuaj mob hauv tebchaws Canada, rau cov neeg mob tsis mus pw hauv tsev kho mob uas tau kuaj pom tus mob coronavirus tshiab (SARS-CoV-2) thiab muaj tsawg kawg ib qhov kev pheej hmoo cuam tshuam nrog nrog rau cov teeb meem tsis zoo tshwm sim rau cov neeg laus tau muab molnupiravir ob zaug ib hnub rau 5 hnub hauv 5 hnub lossis tsawg dua tom qab pib muaj tsos mob. Cov ntaub ntawv hauv ntu no cia siab tias yuav tso tawm nyob rau ib nrab ntawm xyoo 2021.

Cov qauv tshuaj ntawmmolnupiravir(daim duab qhov chaw: scinexx.de)

Molnupiravir yog qhov muaj peev xwm hais tau zoo ntawm cov tshuaj ribonucleoside uas tuaj yeem tiv thaiv kev rov ua ntau yam ntawm RNA tus kab mob, suav nrog tus kabmob tshiab (SARS-CoV-2), uas yog tus kabmob uas ua rau COVID-19.molnupiravirtau pom tias ua haujlwm nyob rau ntau qhov qauv ua ntej ntawm SARS-CoV-2, suav nrog rau kev tiv thaiv, kev kho mob, thiab kev tiv thaiv kev sib kis, thiab tseem tau qhia ua haujlwm hauv preclinical qauv ntawm SARS-CoV-1 thiab MERS.

MOVe-AHEAD (MK-4482-013, NCT04939428) yog theem 3, ntau tus lej, sib piv, ob-qhov muag tsis pom, cov tshuaj placebo tswj hwm uas yuav ntsuas qhov ncauj molnupiravir thiab cov placebo los tiv thaiv SARS hauv tsev neeg ntawm cov neeg uas tau kis nrog COVID-19- Kev ua tau zoo thiab nyab xeeb ntawm kev sib kis CoV-2. Qhov kev sim yuav cuv npe txog 1332 tus neeg koom, uas yuav raug faib ua 2 pawg, nojmolnupiravir(800mg) lossis cov placebo hais lus txhua txhua 12 teev rau 5 hnub.

Txoj kev tshawb no yuav cuv npe koom nrog ≥18 xyoo uas nyob hauv ib qho chaw ib yam li cov uas tau kuaj pom tus mob SARS-CoV-2, muaj tsawg kawg yog ib qho cim lossis tsos mob ntawm COVID-19, thiab cov cim thiab tsos mob tsis tshaj 5 hnub qub. Hauv tsev neeg. Cov neeg koom nrog uas tau txais thawj koob tshuaj tiv thaiv COVID-19 ntau dua 7 hnub ua ntej rau npe kawm, tau muaj tus kab mob COVID-19 yav dhau los, lossis tau pom cov cim lossis tsos mob ntawm COVID-19 yuav tsis tsim nyog.

Cov ntsiab lus kawg ntawm txoj kev tshawb no suav nrog: feem pua ​​ntawm cov neeg koom nrog uas tsim COVID-19 (kuaj pom-pom cov tsos mob ntawm SARS COV-2 kis) nyob rau lub sijhawm 14-hnub, feem pua ​​ntawm cov neeg koom nrog uas muaj xwm txheej tsis zoo, thiab feem pua ​​ntawm cov neeg koom nrog leej twg txiav kev kawm cuam tshuam vim muaj xwm txheej tsis zoo.

Kev sim yuav ua thoob ntiaj teb, suav nrog Argentina, Brazil, Colombia, Fabkis, Guatemala, Hungary, Nyij Pooj, Mexico, Peru, Philippines, Romania, Russia, South Africa, Spain, Turkey, Ukraine thiab Tebchaws Meskas.