Inter J Cancer: Cocoon! Ua Rau Lub Siab Quav Yooj Yim Hloov Mus Rau Txoj Kev Mob Khees Xaws!

Cov kws tshawb fawb ntawm Centennial Research Institute hauv Sydney, Australia tau tshaj tawm txog lub tswvyim tshiab los tawm tsam tus mob melanoma. Melanoma yog ib tus neeg mob qog nqaij hlav tawv tshaj plaws, tua kwv yees li 1, 700 tib neeg nyob hauv Australia txhua txhua xyoo.

Cov kws tshawb nrhiav tau siv cov tshuaj los tiv thaiv ob qho kev sib txawv ntawm cov protein thiab pom tias lawv tuaj yeem tua cov mob melanoma tau zoo los ntawm kev coj cov apoptosis (txoj kev mob ntawm tus kheej kev puas tsuaj uas tshwm sim thaum lub cell tsis xav tau ntxiv lawm).

Lub tswv yim kho tshiab no yuav muaj txiaj ntsig zoo rau pab pawg neeg mob melanoma uas tsis teb rau kev kho mob lossis kev txhaj tshuaj tiv thaiv kab mob.

Cov duab los ntawm: Wikipedia CC BY-SA 3 .0

Tus kws sau txog txoj kev tshawb no, Dr. Hsin-Yi Tseng, tus kws tshawb fawb ntawm Centennial Institute' s Melanoma Oncology thiab Immunology Program, hais tias:" Vim tias qib siab ntawm anti-apoptotic protein lossis' tiv' cov protein nyob hauv kab mob qog nqaij hlav cancer melanoma Vim li no, nws tsis yooj yim rau induce apoptosis. Cov roj ntsha tiv thaiv kab mob no pab ua rau cov hlwb melanoma muaj sia nyob thiab loj hlob, thiab qee qhov xwm txheej tseem yuav pab tiv thaiv kev tshaj lij ntawm kev siv tshuaj."

Hauv txoj kev tshawb fawb no, cov kws tshawb fawb sib koom ua ke inhibited cov protein MCL 1 thiab cov protein los ntawm bromodomain thiab sab nraud lub tsev (BET) tsev neeg. Ob qho ntawm cov tshuaj no tau ntseeg ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab pab txhawb kev mob qog ntshav melanoma hauv lub cev.

Dr. Tseng tau hais tias:" Peb qhov kev tshawb fawb qhia tau tias kev sib xyaw ua ke ntawm BET thiab MCL 1 cov tshuaj tiv thaiv kab mob ua rau muaj kev tua tau tus mob melanoma zoo heev. Qhov kev tiv thaiv kev muaj peev xwm ntawm BET thiab MCL 1 cov nqaijrog tsawg zuj zus nyob rau hauv qhov kev txiav txim ntawm cov tshuaj tiv thaiv kab mob thiab ua rau cov qog nqaij hlav tua tus kheej."

Dr. Jessamy Tiffen, tus sau ua ke ntawm txoj kev tshawb no, kuj yog tus tswv cuab ntawm Centennial Institute' s Melanoma Oncology thiab Immunology Program. Nws tau hais tias kev tshawb fawb txog pab pawg yog qhov tseem ceeb thiab muab lub peev xwm tshiab kho cov neeg mob melanoma.

GG quot; Txog li ib nrab ntawm cov neeg mob melanoma tsis teb rau kev siv tshuaj tiv thaiv kab mob, thiab feem ntau cov neeg mob feem ntau pib txhim kho cov kev tiv thaiv kom zoo rau cov tshuaj kho mob. Peb txoj kev tshawb no sim ntau cov tib neeg cov kab mob cell melanoma thiab cov qauv nas. Hauv ob qho xwm txheej no, muaj qhov txo qis ntawm qhov mob melanoma, uas qhia tau tias txoj kev tshawb no yuav nkag mus rau theem tom ntej ntawm txoj kev loj hlob," Dr. Tiffen hais.

Txoj kev tshawb no tau luam tawm nyob rau hauv" International Journal of Cancer" ;. Melanoma yog hom mob khees xaws feem ntau rau cov tub ntxhais hluas hauv Australia, thiab cov neeg no muaj hnub nyoog txij li 15 txog rau 39 xyoos. (los ntawm Bioon.com)