Pem Hauv Ntej Oncol: Qhov Tshawb Pom Tshiab! Cov kab mob lactic Acid yuav txhawb nqa Cov Tsim thiab Kev Loj Hlob Ntawm Cancer

Lub Ib Hlis 18, 2020, Tsis ntev los no, hauv kev tshawb fawb tshaj tawm hauv phau ntawv xov xwm thoob ntiaj teb Frontiers hauv Oncology, cov kws tshawb fawb los ntawm Anschutz University Lub Tsev Kawm Ntawv ntawm Tshuaj thiab lwm lub tsev pom tias lub npe siv los ntawm txhua lub cell hauv lub cev Cov Kua nplaum los ntawm kev ua haujlwm ntawm cov kab mob lactic acid tuaj yeem txhawb nqa canceration ntawm mutant hlwb.

Duab credit: Cov Tsev Noj Qab Haus Huv Hauv Tebchaws

Tus kws tshawb fawb Inigo San Millan tau hais tias peb pom tias cov lactic acid yuav pab ua lub hauv paus hauv kev hloov hlwb, thiaj li qhib lub cell 0010010 # 39; s txheej txheem mob qog noj ntshav. Cov kev tshawb fawb ntsig txog yam yuav pab tau elucidate cov mechanism ntawm kev mob qog noj ntshav qib. Nws xav tias yuav pab tsim kho cov kev kho mob tshiab kom muaj txiaj ntsig zoo tiv thaiv mob qog nqaij hlav los ntawm kev tua cov lactic acid. Lactic acid tsis yog pov tseg, nws yog lub hauv paus ntawm lub zog ntawm tes, tshwj xeeb yog mitochondria.

Kwv yees li ib puas xyoo dhau los, cov kws tshawb fawb xub tau piav txog lub luag haujlwm tseem ceeb ntawm cov kab mob lactic acid hauv kev kho mob qog noj ntshav. Thaum lub sijhawm, Otto Warburg, tus kws tshaj lij Nobel, pom tias lub cim tseem ceeb ntawm cov kabmob kheesxaws tsis yog tsuas yog ua rau cov piam thaj sai sai xwb, tabsis nws tseem yuav ua rau lactic acid ntau ntxiv. Cov txheej txheem no yog hu ua 0010010 quot; War War nyhuv 0010010 quot; Hauv 2017, cov kws tshawb fawb tau dhau los ua kev tshawb fawb Ua rau kwv yees hais tias lawv nthuav tawm qhov tseem ceeb ntawm cov nyhuv Warburg, uas yog, tsim kom muaj cov kab mob lactic acid rau kev tsim mob qog nqaij hlav.

Cov kws tshawb nrhiav San Millan thiab lwm tus tom qab ntawd tau pib paub qhov tseeb no. Lawv nthuav tawm tib neeg cov mob cancer ntawm lub mis mus rau cov kua nplaum ntev, uas ua rau cov lactic acid, uas ua rau muaj kev tawm ntau ntawm cov kev hloov pauv loj hauv cov noob, thiab cov noob no nce ntxiv hauv mob cancer mis 150% -800%. Peb txhua tus paub tias tsis yog txhua lub cell hloov pauv yuav dhau los ua qog, thiab qee qhov kev tshawb fawb tau xav tias yam twg yuav ua rau cov kev hloov pauv ntawm cov noob. Cov kev tshawb fawb cuam tshuam qhia tau hais tias cov lactic acid tuaj yeem yog lub ntsiab tseem ceeb. Tam sim no cov kws tshawb nrhiav hauv cov cell me kab mob ntsws Kev tshawb fawb tab tom ua rau mob qog nqaij hlav kom paub meej seb puas muaj cov txiaj ntsig zoo sib xws.

Cov kws tshawb nrhiav tau hais tias cov lactic acid yuav yog lub cim teeb meem loj thiab cov gene regulator koom nrog kev mob qog noj ntshav, uas txawv ntawm cov lactic acid uas peb tsim thaum ua exercise. Cov kab mob lactic acid tsim tawm thaum lub dag zog lub cev yuav ua tiav sai sai ntawm lub cev. Nws tuaj yeem txhim kho txoj kev noj qab haus huv ntawm lub cev, thiab cov nyiaj ntawm cov kab mob lactic acid tsim thaum lub sijhawm ua haujlwm cancer tseem zoo ib yam. Nws yuav txuas ntxiv tsim khoom thiab ua li Ruihua thiab ua kom lub cev hloov mus rau qhov mob qog noj ntshav. Tam sim no cov kws tshawb nrhiav tseem tsis tau paub meej txog nws Cov tshuab tshwj xeeb molecular.

Tib neeg cov leeg muaj zog tiv taus ntau yam mob cancer. Kev tawm dag zog tuaj yeem txo qee yam mob qog nqaij hlav thiab tuaj yeem kho qee tus mob qog nqaij hlav. Tam sim no cov kws tshawb nrhiav tau pib siv cov kev ua qoj ib ce pab rau kev kho mob qog noj ntshav. Lawv cia siab tias lub tswv yim no yuav raug siv ua ib feem ntawm kev npaj kho mob qog noj ntshav, thiab cov kws tshawb nrhiav kuj tseem yuav qhia ntxiv tias cov kev tawm dag zog tuaj yeem pab tiv thaiv thiab kho mob qog nqaij hlav cancer tau li cas. Cov kws tshawb nrhiav tseem tabtom sim nrhiav txoj hauv kev tshiab los thaiv lactic acid los ntawm kev tawm hauv lub hlwb.

Thaum cov kab mob lactic acid tsim tawm tom qab, nws yuav tawm ntawm tes los ntawm kev thauj khoom. Cov kws tshawb nrhiav xav kawm thiab sim siv cov sib txuas sib txawv los thaiv kev tsim cov kab mob lactic acid hauv qog hlwb thiab lactic acid hauv hlwb mob ntshav. Yuav tsis ua. Tab sis kev sim siv cov tshuaj rau lub cev muaj zog tiv thaiv cov kab mob lactic acid hauv lub cev tuaj yeem ua rau neeg tuag taus, yog li cov kws tshawb nrhiav xav tau cov hom phiaj kho ntxiv. Ib qho ntxiv, lactic acid los ntawm cov kabmob kheesxaws kuj tseem tuaj yeem ua qhov tseem ceeb 0010010 quot; player 0010010 quot; txhawm rau tiv thaiv lub cev tiv thaiv kabmob hlwb tsis tu ncua.

Thaum kawg, tus kws tshawb fawb San Millan tau hais tias tam sim no lawv kawm hauv qhov tob kom sim lactic acid uas ua los ntawm cov qog nqaij hlav sib txawv tau cog hauv cov nas. Yog tias lawv muaj peev xwm ua tau hom phiaj lactic acid, cov neeg tshawb xyuas yuav vam tias yuav muaj tus neeg tshiab los xaus rau Kev Siv Tshuaj Kuaj Mob Cancer. (los ntawm Bioon.com, sau hsppharma.com)

thawj qhov chaw:

Iñigo San-Millán li al. 0010010 nbsp;Puas yog Lactate ib Oncometabolite? Pov Thawj Txhawb Txoj Haujlwm rau Lactate nyob hauv txoj cai ntawm kev hloov pauv kev ua haujlwm ntawm Cov Kab Mob Ntawm Kab Mob Cancer hauv MCF 7 Lub Hlwb Mob Cancer Ntawm Lub Cev, 0010010 nbsp;Cov Hauv Paus hauv Oncology 0010010 nbsp; ({{1})). DOI: 10. 3389 / fonc. 2019. 01536