Zanubrutinib CAS TSIS: 1691249-45-2

Khoom Qhia:

Khoom npe: Zanubrutinib CAS TSIS: 1691249-45-2

Txhais:

(7S) -2- (4-Phenoxyphenyl) -7- (1- (prop-2-enoyl) piperidin-4-yl) -4,5,6,7-tetrahydropyrazolo (1,5-a) pyrimidine-3 -carboxamide;

(7S) -7- (1-Acryloyl-4-piperidinyl) -2- (4-phenoxyphenyl) -4,5,6,7-tetrahydropyrazolo [1,5-a] pyrimidine-3-carboxamide;

Tshuaj& Cov Khoom Uas Lub Cev:

Zog: Dawb kom dawb-dawb hmoov.

Ntsuas: ≥98.0%

Qhov ceev: 1.33g / cm3

Melting point: N / A

Lub Ntsiab Lus Boiling: 713.4 ℃

Flash Point: N / A

Qhov nqe lus zam: N / A

Vapor Siab: 0.0mmHg ntawm 25 ° C

PSA: 102.48000

LogP: 4.99880

Solubility: Soluble hauv DMSO,> 50 mg / ml hauv DMSO. Ethanol:< 1="" mg="" ml="">

Pawg: Tshuaj Cawv; Kws Tshuaj / API Tshuaj Tshuaj Nruab Nrab;

Cov Ntaub Ntawv Kev Nyab Xeeb:

HS Code: 2933599090

Cia ： Muab cia rau qhov chaw txias thiab qhuav kaw zoo kaw. Cia kom deb ntawm ya raws thiab muaj zog lub teeb / cua sov.

Daim ntawv thov:

Zanubrutinib yog qhov xaiv Bruton tyrosine kinase (BTK) inhibitor ..

Zanubrutinib (BGB3111) yog qhov muaj zog, xaiv thiab qhov ncauj Btk inhibitor; displaymuch txwv ntau qhov txwv-phiaj xwm kev ua haujlwm tiv thaiv ib lub vaj huam sib luag ntawm kinases, suav nrog ITK, piv nrog Ibrutinib. BGB-3111 xaiv yeem khi thiab khi rau txoj haujlwm ntawm BTK thiab tiv thaiv kom tsis txhob muaj kev ua haujlwm ntawm B-cell antigen receptor (BCR) kev taw qhia.

Peb lub Hoobkas tsim khoom (S) -Zanubrutinib, tshuab paub tab, cov khoom lag luam ruaj khov, kev lees paub zoo.

Cov Ntaub Ntawv Nres: Muaj Hauv Tshuag.

Peb tuaj yeem muab (7S) -4,5,6,7-Tetrahydro-7- [1- (1-oxo-2-propen-1-yl) -4-piperidinyl] -2- (4-phenoxyphenyl) pyrazolo [ 1,5-a] pyrimidine-3-carboxamide COA (daim ntawv pov thawj ntawm kev tsom xam), MOA (Txoj kev tsom xam), Pyrazolo (1,5-a) pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-7 - (1- (1-oxo-2-propen-1-yl) -4-piperidinyl) -2- (4-phenoxyphenyl) -, (7S) - ROS (Txoj kev ntawm synthesis), CAS 1691249-45-2 MSDS (Khoom Siv Cov Ntaub Ntawv Kev Nyab Xeeb Cov Ntaub Ntawv) thiab lwm yam kev txhawb nqa rau koj!

Related Zanubrutinib:

(±) -Zanubrutinib CAS: 1633350-06-7 (haiv neeg)

(S) -Zanubrutinib CAS: 1691249-45-2 (S-isomer)

(R) -Zanubrutinib CAS: 1691249-44-1 (R-isomer)

Hauv Vitro:

Zanubrutinib (BGB-3111) yog tus xaiv Bruton tyrosine kinase (BTK) inhibitor. Hauv ob qho kev cog qoob loo biochemical thiab cellular, Zanubrutinib ua qauv qhia txog nanomolar BTK kev txwv tsis pub ua ub no. Hauv ob peb lub MCL thiab DLBCL kab xovtooj, Zanubrutinib inhibits BCR kev sib sau ua ke-ua rau BTK autophosphorylation, thaiv cov dej ntws los ntawm PLC-γ2 cov cim, thiab lub zog tawm ntawm tes kom loj hlob ntawm tes. Hauv kev sib piv nrog PCI-32765, Zanubrutinib qhia ntau qhov kev txwv ntau dhau ntawm cov phiaj xwm kev ua haujlwm tiv thaiv cov vaj huam sib luag ntawm kinases, suav nrog ITK [1].

Hauv Vivo:

Zanubrutinib (BGB-3111) tsim cov tshuaj tiv thaiv qog tiv thaiv qog mob tiv thaiv REC-1 MCL xenografts ua rau xaim duab los yog kaw lus los ntawm tus Tsov tus tw txhaj rau hauv nas. Hauv subcutaneous xenografts, Zanubrutinib ntawm 2.5 mg / kg BID qhia cov haujlwm zoo ib yam li PCI-32765 ntawm 50 mg / kg QD. Hauv cov qauv txheej txheem, cov muaj sia nyob nruab nrab ntawm Zanubrutinib 25 mg / kg BID pawg yog lub sijhawm ntev dua li ntawm ob qho ntawm PCI-32765 50 mg / kg QD thiab BID pawg. Hauv qhov ABC-subtype DLBCL (TMD-8) subcutaneous xenograft qauv, Zanubrutinib kuj qhia tau zoo dua los tiv thaiv qog ua haujlwm zoo dua li PCI-32765. Kev Kawm Ua Ntej 14-hnub ua tshuaj lom rau hauv cov nas qhia tau pom tias Zanubrutinib pom zoo zoo thiab muaj peev xwm tiv taus ntau tshaj plaws (MTD) tsis tau txog thaum nws tau sau ntawv txog 250 mg / kg / hnub [1].

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: zanubrutinib cas tsis yog: 1691249-45-2, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: Ibrutinib CAS TSIS 936563-96-1
• Tom ntej: 5-Ethyluracil CAS TSIS MUAJ 4212-49-1