Fetcroja (cefiderocol): Kev Ua Haujlwm Zoo Tshaj Tawm Txog Qhov Tseem Ceeb Ua Ntej Gram-negative Bacteria! --- 1/2

Nyij Pooj tuam txhab lag luam Shionogi tsis ntev los no tshaj tawm cov ntaub ntawv tseem ceeb ntawm cov tshuaj tua kab mob tshiab Fetcroja (cefiderocol) ntawm European Conference on Clinical Microbiology and Infectious Diseases (ECCMID). Cefiderocol yog lub ntiaj teb' thawj siderophore cephalosporin uas siv cov kab mob' tus kheej lub cev nqus cov hlau nkag mus rau cov kab mob hauv lub cev zoo ib yam li&"Trojan nees &" ;. Cefiderocol muaj cov tshuaj tiv thaiv kab mob vitro tiv thaiv ntau yam kab mob aerobic Gram-negative pathogens.

cefiderocol yog thawj qhov pom zoo tshuaj tua kab mob nrog siderophore muaj nuj nqi. Nws tau pom zoo hauv Tebchaws Meskas thaum Lub Kaum Ib Hlis 14, 2019 (Fetroja) thiab lub Plaub Hlis 2020 hauv European Union (Fetcroja). Nws tau siv rau cov neeg mob uas muaj kev txwv lossis tsis muaj kev xaiv kho mob. Cov neeg mob laus hnub nyoog 18 xyoo thiab laus dua kho tus kab mob tshwm sim los ntawm cov kab mob Gram-negative.

Cefiderocol yog tus tshiab siderophore cephalosporin nrog cov txheej txheem tshwj xeeb ntawm kev nkag mus rau cov cell membrane ntawm cov kab mob Gram-tsis zoo (suav nrog cov kab mob ntau yam tiv taus kab mob). Nws muaj peb lub tswv yim tseem ceeb rau kev kov yeej carbapenem tsis kam (porin raws). Hloov pauv, β-lactamase inactivation, ua haujlwm ntau dhau ntawm cov twj tso kua mis). Cefiderocol khi rau cov hlau ferric thiab tau nquag thauj mus rau hauv cov kab mob ntawm tes los ntawm txheej sab nrauv ntawm daim nyias nyias ntawm tes los ntawm cov kab mob thauj cov hlau. Lub tswv yim nees Trojan no tso cai rau cefiderocol kom nkag siab ntau dua hauv cov kab mob cell periplasm, khi rau penicillin khi cov protein hauv thaj chaw periplasmic thiab tiv thaiv kab mob cell cell phab ntsa synthesis.

Cov ntaub ntawv los ntawm cefiderocol kev saib xyuas ntau haiv neeg hauv ntiaj teb qhia tias cefiderocol muaj txiaj ntsig tiv thaiv dav-spectrum aerobic Gram-negative pathogens hauv vitro (suav nrog tag nrho peb yam tseem ceeb kab mob ua ntej teev los ntawm World Health Organization): carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, refractory carbapenem-resistant Enterobacter ) thiab Stenotrophomonas maltophilia muaj lub zog tiv thaiv kab mob. Ib qho ntxiv, cefiderocol kuj tseem tiv taus ntau yam tshuaj tiv thaiv kab mob (xws li txuas ntxiv-spectrum β-lactamase [ESBL], AmpC lact-lactamase [AmpC], serine carbapenemase thiab hlau carbapenemase). Cov kab mob no muaj zog hauv vitro cov tshuaj tua kab mob.

Tshuaj tiv thaiv kab mob tiv thaiv kab mob (AMR) yog lub nra hnyav rau kev noj qab haus huv uas yuav tsum tau hais daws. Raws li txoj hauv kev tshwj xeeb ntawm kev nkag mus rau ntawm phab ntsa ntawm cov kab mob gram-tsis zoo thiab muaj peev xwm kov yeej ntau yam kev tiv thaiv kab mob rau cov tshuaj tua kab mob, cefiderocol tau pab ua kom qhov tseem ceeb tsis xav tau kev kho mob.

cefiderocol molecular qauv