Eli Lilly's $ 1 Billion Tau Txais Protomer: Kev Txhim Kho Ntawm Glucose-responsive Insulin

Eli Lilly tsis ntev los no tshaj tawm qhov kev yuav khoom ntawm lub tuam txhab biotechnology Protomer Technologies, uas muaj cov peptide uas muaj cov tswv cuab thiab cov txheej txheem tsim hluav taws xob uas tuaj yeem siv los txheeb xyuas thiab sib sau ua ke cov lwg me me uas tuaj yeem paub txog kev tswj hwm cov piam thaj lossis lwm yam kev ua haujlwm protein. Nrog kev ua tiav ntawm kev txhim kho yav tom ntej thiab kev lag luam tseem ceeb, lub peev xwm ntawm kev sib pauv ntau dua US $ 1 nphom. Ua ntej qhov no, Eli Lilly thiab JDRF T1D Fund tau coj kev nqis peev nqis peev hauv Protomer, muab Eli Lilly koom nrog 14% hauv tuam txhab. Eli Lilly tau txais cov khoom seem uas seem dhau ntawm nws cov peev txheej pib hauv Protomer.

Protomer tau tsim muaj xyoo 2015 thiab muaj lub hauv paus chaw haujlwm hauv Pasadena, California. Nws tab tom tsim thiab tsim kho ib tiam tshiab ntawm kev kho cov protein uas tuaj yeem paub txog cov txheej txheem molecular hauv tib neeg lub cev thiab ua kom lawv tau txais raws li xav tau. Lub tuam txhab cov tswv lag luam Molecular Engineering ntawm Protein Sensors (MEPS) lub platform raws li tshuaj lom neeg lom neeg tuaj yeem txhim kho kev kho peptides thiab cov protein nrog kho cov haujlwm. Cov peptides thiab cov protein no tuaj yeem tswj hwm los ntawm cov txheej txheem me me kom ua tiav qhov txawv txav thiab kev tswj hwm. Protomer tau siv txoj hauv kev no txhawm rau txhawm rau txhim kho cov neeg sib tw kho mob, suav nrog cov tshuaj insulin-glucose teb, uas tuaj yeem nkag siab cov ntshav qabzib hauv cov ntshav thiab qhib nws tau raws li xav tau txhua hnub.

Kev kho cov haujlwm ntawm cov protein kho tom qab txhaj tshuaj yog txoj hauv kev zoo los txhim kho kev nyab xeeb thiab ua tau zoo. MEPS lub platform coj txoj hauv kev kho tshuaj kom haum rau tus kheej rau cov tshuaj tiv thaiv kab mob, tso cai rau kev siv tshuaj sib txawv uas haum rau txhua tus neeg' nws lub cev tshwj xeeb thiab kho cov lus teb. MEPS tseem tuaj yeem paub txog kev tswj hwm kev ua haujlwm tsis siv neeg ntawm kev qhib sai thiab kaw thiab hom-homing hom phiaj kho kom txo qis qhov cuam tshuam.

Ruth Gimeno, tus lwm thawj coj ntawm kev tshawb fawb ntshav qab zib thiab tshawb fawb soj ntsuam ntawm Eli Lilly, tau hais tias: "Lilly tau mob siab rau ua lub neej ntawm cov neeg mob ntshav qab zib kom zoo dua rau lub sijhawm ntev, thiab peb tseem tau txiav txim siab muab cov kev daws teeb meem tiag tiag, suav nrog kev hloov pauv hauv insulin kev kho mob. Ntshav qab zib. Cov tshuaj insulin rhiab yog thaj tsam tom ntej. Los ntawm kev txhim kho kev ua tau zoo thiab kev nyab xeeb ntawm kev kho tshuaj insulin, nws muaj peev xwm hloov pauv kev kho mob thiab lub neej zoo ntawm cov neeg mob ntshav qab zib. Protomer' txoj haujlwm insulin-sensitive insulin yog ua raws nws cov peev txheej muaj protein ntau sensor molecular engineering Lub (MEPS) lub platform tau qhia txog kev cog lus zoo, thiab Eli Lilly zoo siab siv lub tuam txhab cov thev naus laus zis los txhim kho peb cov ntshav qab zib."

Katie Ellias, Tus Thawj Coj ntawm JDRF T1D Fund, tau hais tias: "Qhov no yog lub hom phiaj tseem ceeb rau Hom 1 Ntshav Qab Zib (T1D) zej zog thiab cov kauj ruam tseem ceeb hauv kev coj Protomer kev hloov pauv kev siv tshuab cog lus ze rau lub tsev kho mob. Kev txhawb nqa thiab kev nqis peev yog lub cim ntawm peb cov phiaj xwm phiaj xwm los pab cov tuam txhab nrog kev tshawb fawb tshiab txhawm rau txhim kho kev kho lub neej tom ntej rau T1D cov neeg mob. Peb zoo siab heev uas Protomer tau koom nrog Eli Lilly tsev neeg, lub tuam txhab tau cog lus tias yuav muab kev daws teeb meem rau cov neeg mob ntshav qab zib raws li peb yog Txoj Haujlwm."