Qhov teeb meem FDA

Lub asthiv dhau los, Asmeskas FDA tau tshaj tawm 15 cov tub ntxhais hluas cov kws muaj peev xwm ua yeeb tshuaj nyob rau hauv ib qho ua pa, suav nrog ntau yam tshuaj rau kev kho mob siab mob cancer, mob plab, thiab mob plab biliary.

kho mob cancer

Ntawm cov no 15 tshuaj, 5 yog siv rau kev kho mob qog nqaij hlav, suav nyiaj ib feem peb. Ntawm lawv, kev kho mob ntawm tes TCB 002 coj los ntawm TC BioPharm yog cov tshuaj tsuas kho mob ntshav ntshav. Qhov no yog" allogeneic"" npaj-rau-siv" kev kho mob cell rau nthuav CD3-zoo gamma del T cell. Nws tau nkag mus hauv cov chaw kuaj mob los kho tus mob pob myeloid.

Tshuav plaub yam tshuaj tua kabmob cancer kho cov qog, uas AstraZeneca' s PD-L 1 inhibitor Imfinzi (durvalumab) thiab CTLA-4 inhibitor tremelimumab yog cov tub ntxhais muaj peev xwm ua yeeb tshuaj rau hepatocellular carcinoma. Silydi' s subcutaneous PD-L 1 tshuaj tiv thaiv envafolimab tsim nyog rau chaw tu menyuam ntsuag tsom rau tus mob biliary mob cancer. OBI-999 ntawm Taiwan Hao Ding Tuam Txhab yog ib qho tshuaj tiv thaiv tshuaj tiv thaiv kab mob tiv thaiv kab mob Globo-H antigen, thiab nws cov peev xwm tshuaj xyuas chaw ua haujlwm yog tsom rau cov qog nqaij hlav cancer.

Kev kho noob

Peb kuj tau pom qee qhov kev kho mob gene, xws li ib qho los ntawm Esteve Pharmaceuticals, uas tau siv lub AAV 9 gene vector los qhia cov GALNS ib txwm muaj rau cov neeg mob los kho tus mob IVA mucopolysaccharidosis; lwm txoj kev kho mob los ntawm Baxalta yog Lub gene encoding FIX Padua tau pauv mus rau cov neeg mob AAV 8 vector los kho tus mob hemophilia hom B.

Aruvant Sciences yog ib txoj kev kho mob uas siv lentiviral vectors. Nws qhia tawm cov gene encoding γ-globin rau hauv tus neeg mob' s tus kheej lub hlwb CD34 kom kho tau tus mob ntshav liab zoo ntshav. Lwm txoj kev kho mob zoo sib xws yog los ntawm Orchard Kev Kho Mob, uas kuj siv CD34-cov hlwb zoo. Qhov sib txawv yog tias nws hloov lub gp 91 phox noob los kho X-chromosome-txuas nrog kev mob granulomatosis.

Lwm yam kab mob tsawg

Ntxiv nrog rau mob qog noj ntshav thiab kab mob uas tsis tshua muaj tuaj yeem kho nrog kev kho noob, lwm yam kab mob tsawg kuj muaj feem tsim cov tshuaj tshiab. Cov Tshuaj Tsw Siv Woolsey' fasudil yog ROCK inhibitor, uas xav kom kho amyotrophic lateral sclerosis; OncoArendi Tshuaj Kho' OATD-01 yog CHIT-1 inhibitor tshiab, uas xav tias yuav raug siv rau kev kho mob ntawm sarcoidosis; Rebasez (Luspatercept) yog tus kabmob ntshav liab rau cov neeg laus txoj kev loj hlob, thiab tus kabmob raug tsom los ntawm tus menyuam ntsuag tsimnyog tshuaj yog pob txha caj mob.

Ntawm cov tshuaj no uas tsim nyog rau cov tshuaj ntsuag, tseem muaj qee cov tshuaj tiv thaiv. Ntawm lawv, Danuo Tshuaj' s TNP {{{2}} tau txais kev tsim nyog rau khoom cuav sib koom ua ke. Sij hawm dhau los, nws tseem tau ua tiav los ntawm FDA los ua cov khoom lag luam tawm tsam. F 2 G' s olorofim tau ob lub chaw ntsuag tshuaj ntsuab tsim nyog, feem rau kis ntawm Lomentospora / Scedosporium thiab tus mob aspergillosis.