Eli Lilly Txoj Kev Kawm Taub Hau Taub Hau Pib Rau Cov Neeg Mob: Sib piv Monoclonal Antibody Emgality Nrog Cov Tshuaj Hauv Qhov Ncauj Nurtec ODT!

Eli Lilly tsis ntev los no tau tshaj tawm tias kev tso npe tus neeg mob hauv CHALLENGE-MIG kev sim tshuaj tau pib. Qhov no yog thawj zaug thiab tsuas yog ib qho los sib piv ob qho tshuaj anticalcitonin gene-related peptide (CGRP) rau kev tiv thaiv kev qaug dab peg hauv cov neeg laus Head-to-head test rau kev sib deev migraine (EM). Txoj kev tshawb no yuav tsum sau npe txog 700 tus neeg laus cov neeg mob nrog paroxysmal migraine hauv Tebchaws Meskas. Nws yuav piv Emgality (galcanezumab-gnlm, txhaj subcutaneously ib hlis ib zaug) nrog Nurtec®ODT (rimegepant), thiab siv cov ntsuas tus neeg mob hauv nruab nrab. Qhov no suav nrog txo tus naj npawb ntawm migraine tawm tsam ib hlis thiab txhim kho lub neej zoo.

Calcitonin gene-related peptide (CGRP) yog cov protein nyob hauv lub hlwb uas xav tias ua lub luag haujlwm tseem ceeb hauv kev mob migraine. Txawm hais tias ob qho tib si Nurtec ODT thiab Emgality yog cov tshuaj uas tsom CGRP, vim tias Emgality yog monoclonal antibody (mAb) uas khi rau CGRP, nws cov nyhuv txawv ntawm Nurtec ODT thiab lwm yam tshuaj uas khi rau CGRP receptors thiab thaiv CGRP receptors. .

Txoj kev tshawb nrhiav CHALLENGE-MIG tau tsim lub sijhawm no txhawm rau nkag siab tob txog lub luag haujlwm ntawm CGRP monoclonal antibody (mAb) hauv kev tiv thaiv kev kho mob migraine thiab teb qee cov lus nug tseem ceeb los pab kws kho mob thiab cov neeg mob txiav txim siab kho mob.

Shivang Joshi, tus kws tshawb fawb hauv CHALLENGE-MIG txoj kev tshawb fawb thiab kws kho mob paj hlwb ntawm Dent Neurologic Institute hauv New York, tau hais tias:" Migraines tuaj yeem cuam tshuam rau kev ua ub no thiab ua rau tib neeg lub neej txhua hnub thiab cov haujlwm tshwj xeeb. Txo. Qhov zaus ntawm migraine tawm tsam tuaj yeem pab tib neeg tau ntau hnub tsis muaj migraine thiab txaus siab rau lub neej zoo dua; ob qho no yog cov hom phiaj kho mob tseem ceeb. Eli Lilly's CHALLENGE-MIG txoj kev kawm yuav pab peb nkag siab txog ntau hom Kev Tiv Thaiv Tuam Tshoj li cas (CGRP monoclonal antibodies thiab geptants) pab tib neeg ua tiav cov hom phiaj tseem ceeb tshaj plaws rau lawv. Nws yog qhov zoo siab tias qhov kev nkag siab tsim tawm hauv thawj lub taub hau-rau-lub taub hau sim ntawm nws hom yuav txhawb nqa migraines Kev Sib Tham txog kev npaj kho mob ntawm tus neeg mob thiab nws tus kws kho mob."

Migraine yog tus kab mob thib peb tshaj plaws thiab yog thib rau tus kab mob uas tsis muaj peev xwm tshaj plaws hauv ntiaj teb. Nws yog ib hom kab mob neurovascular uas tshwm sim los ntawm kev mob taub hau hnyav, feem ntau hemilateral. Nws tau kwv yees tias tag nrho cov neeg mob migraine thoob ntiaj teb muaj tshaj li 1 billion, thiab li ntawm 90% yog episodic migraine (EM), uas yog tus yam ntxwv txog li 14 hnub migraine ib hlis; qhov seem 10% yog mob migraine (CM), uas yog tshwm sim los ntawm qhov tshwm sim ntawm mob taub hau tsawg kawg yog 15 hnub hauv ib lub hlis, ntawm 8 hnub lossis ntau dua yog migraines, thiab tus neeg mob lub sijhawm ntev dua 3 lub hlis. Tam sim no, tsis muaj tshuaj uas yuav kho tau migraine. Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Hauv Ntiaj Teb (WHO) tau teev cov kab mob migraine yog ib qho ntawm 10 cov kab mob uas tsis zoo tshaj plaws. Piv nrog rau lwm cov neeg, cov neeg mob migraine feem ntau yuav raug kev nyuaj siab, kev ntxhov siab, pw tsaug zog, lwm yam mob thiab qaug zog.

Calcitonin-related gene peptide (CGRP) yog ib qho neuropeptide uas tau pom tias raug tso tawm thaum muaj mob migraine thiab suav tias yog qhov ua rau mob migraine. Tam sim no, CGRP thiab nws cov receptors tau dhau los ua lub hom phiaj nrov rau kev txhim kho cov tshuaj migraine.

Txog rau tam sim no, 4 monoclonal antibody migraine kho uas lub hom phiaj CGRP thiab nws cov receptors tau ua lag luam, suav nrog: Eli Lilly Emgality (targeting CGRP), Amgen / Novartis Aimovig (targeting CGRP receptor), thiab Ling North Vyepti (targeting CGRP), Teva Ajovy (Lub hom phiaj CGRP). Hais txog cov tshuaj, ob qho tib si Emgality thiab Aimovig tau txhaj tshuaj subcutaneously ib hlis ib zaug, Ajovy tuaj yeem txhaj tshuaj subcutaneously ib hlis ib zaug lossis ib zaug txhua 3 lub hlis, thiab Vyepti txhaj tshuaj txhua 3 lub hlis.

Ntawm lawv, Emgality tau pom zoo los ntawm US FDA thaum lub Cuaj Hlis 2018 rau kev tiv thaiv kev kho mob ntawm cov neeg laus mob migraine. Thaum Lub Rau Hli 2019, Emgality tau rov pom zoo los ntawm US FDA rau kev kho mob ntawm cov neeg laus pib mob taub hau (ECH). Nws tsim nyog hais tias Emgality yog thawj cov tshuaj kho ECH thiab thawj CGRP antibody uas tuaj yeem kho 2 kab mob sib txawv.

Nurtec ODT tau tsim los ntawm Biohaven thiab tau pom zoo thaum Lub Ob Hlis 2020 rau kev kho mob ntawm cov neeg laus mob migraine (nrog lossis tsis muaj aura), tsis hais tus naj npawb ntawm migraine hnub hauv ib hlis. Thaum lub Tsib Hlis 2021, Nurtec ODT tau pom zoo rau qhov qhia tshiab: nws yog siv rau kev tiv thaiv kev kho mob migraine. Nws yog tshwj xeeb yog muaj feem xyuam rau cov neeg laus cov neeg mob uas muaj mob migraine episodic (EM) uas muaj tsawg dua 15 hnub mob taub hau hauv ib hlis.

Nws yog tsim nyog hais tias Nurtec ODT yog thawj qhov ncauj CGRP antagonist pom zoo rau kev tiv thaiv kev kho mob migraine thiab thawj cov tshuaj migraine tau pom zoo rau kev kho mob hnyav thiab kev tiv thaiv kev kho mob.