Winlevi qab zib, tshuaj pleev androgen receptor inhibitor, yuav pib sai sai: nws haum rau txiv neej thiab poj niam!

Sun Pharma thiab Cassiopea SpA, lub ntiaj teb thib plaub loj tshaj plaws cov tshuaj tsim tawm thiab Is Nrias teb tus tsim tshuaj loj tshaj plaws, koom ua ke tshaj tawm tias ob tog tau kos npe tso cai thiab muab kev pom zoo rau Winlevi (clascoterone 1%) qab zib hauv Tebchaws Meskas thiab Canada. Winlevi tau txais kev pom zoo los ntawm Asmeskas FDA thaum Lub Yim Hli 2020. Cov tshuaj yog hom tshuaj tshiab nrog lub cim tshwj xeeb ntawm kev nqis tes ua. Raws li tshuaj pleev tshuaj, nws tau siv los kho pob txuv vulgaris (pob txuv vulgaris) hauv cov neeg mob hnub nyoog 12 xyoos thiab laus dua. Pob txuv yog kab mob ntawm daim tawv nqaij feem ntau hauv Tebchaws Meskas, cuam tshuam rau 50 lab tus tib neeg txhua xyoo, tab sis FDA tau pom zoo zaum kawg siv cov tshuaj pob txuv nrog cov txheej txheem tshiab ntawm kev ua (MOA) ze li 40 xyoo dhau los.

Raws li cov lus cog tseg, Sun Pharma yuav muaj txoj cai tshwj xeeb rau kev lag luam Winlevi hauv Tebchaws Meskas thiab Canada, thiab Cassiopea yuav yog tus muab khoom tshwj xeeb ntawm cov khoom. Cassiopea yuav tau txais kev them nyiaj ua ntej ntawm US $ 45 lab, cov peev txheej tseem ceeb hauv kev lag luam them nyiaj tag nrho US $ 190 lab, thiab 2-tus lej nqi ncaj ncees raws li kev muag khoom. Qhov kev pom zoo yuav pib siv tom qab lub sijhawm tos ntawm US HSR Act tau dhau mus.

Winlevi cia siab tias yuav mus muag hauv Tebchaws Meskas nyob rau plaub lub hlis xyoo 2021. Abhay Gandhi, CEO ntawm Sun Pharma North America, tau hais tias: "Sun Pharma zoo siab heev los koom tes nrog Cassiopea SpA. Winlevi yog cov tshuaj pleev tshuaj tshiab hauv daim tawv nqaij uas yuav ntxiv rau peb cov khoom siv pob txuv qhov ncauj uas twb muaj lawm. Qhov ntxiv ntawm Winlevi ntxiv dag zog rau Peb txoj haujlwm hauv thaj tsam pob txuv thiab ntxiv dag zog rau peb txoj kev mob siab rau saib xyuas cov neeg mob thiab hloov lawv lub neej."

Pob txuv yog kab mob ntawm daim tawv nqaij multifactorial uas cuam tshuam los ntawm 4 txoj hauv kev sib txawv: tso cov roj ntau dhau (sebum), txhaws qhov hws (hyperkeratosis), cov kab mob loj hlob (Corynebacterium acnes), thiab mob o. Cov kev kho hauv nroog tsom rau androgens yog qhov xav tau tseem ceeb hauv kev kho mob pob txuv, thiab androgens tsav sebum ntau lawm thiab ua rau mob loj heev.

Winlevi (clascoterone 1%, cream) yog thawj cov tshuaj pob txuv nrog cov txheej txheem tshiab ntawm kev nqis tes ua (MOA) pom zoo los ntawm Asmeskas FDA hauv 40 xyoo dhau los, thiab yuav muab cov kws kho mob dermatologists thiab cov neeg mob nrog txoj kev kho tshiab thiab muaj txiaj ntsig zoo. Tsis zoo li cov tshuaj hormones hauv qhov ncauj siv los kho pob txuv, Winlevi tuaj yeem siv rau ob tus txiv neej thiab poj niam mob.

Cov khoom siv tshuaj muaj zog ntawm Winlevi yog clascoterone, uas yog thawj-hauv-chav kawm tshuaj pleev androgen receptor inhibitor tsim los daws cov androgen tivthaiv ntawm txiv neej thiab poj niam pob txuv. Lub luag haujlwm ntawm androgen receptor inhibitors yog txwv cov kev mob tshwm sim ntawm cov tshuaj no kom nce sebum. Clascoterone yog cov tshuaj me me uas tuaj yeem nkag rau ntawm daim tawv nqaij kom mus txog qhov androgen receptors hauv cov qog sebaceous thiab cov hauv paus plaub hau. Cov tshuaj no yog thawj qhov kev nyab xeeb thiab muaj txiaj ntsig tshuaj pleev tshuaj androgen inhibitor tsis muaj kev phiv tshuaj.

Cov qauv txheej txheem ntawm clascoterone (daim duab qhov chaw: medchemexpress.cn)

Winlevi siv cov tshuaj pleev ib hnub ob zaug ib hnub los ua qhov tshuaj androgen receptor ntawm qhov chaw siv tshuaj txhawm rau txhawm rau txhawm rau thaj tsam (tawv nqaij) ntawm dihydrotestosterone (DHT). DHT yog qhov tseem ceeb tsav tsheb rau qhov tshwm sim ntawm pob txuv. Kev tshawb fawb hauv chav kuaj pom pom tias clascoterone tuaj yeem tiv thaiv lipid ntau lawm hauv cov roj tsim cov cell (sebcyte) thiab txo qis pro-inflammatory cytokines thiab cov kws kho nruab nrab cuam tshuam los ntawm androgens. Yog li ntawd, txoj hauv kev uas txhawb nqa qhov tshwm sim ntawm pob txuv raug rhuav tshem los ntawm clascoterone.

Cov ntaub ntawv los ntawm ob theem tseem ceeb 3 kev sim tshuaj kho mob pom tias Winlevi tau qhia txog kev txhim kho tseem ceeb hauv txhua qhov kev soj ntsuam zaum kawg, qhia txog kev kho pob txuv kom zoo thiab txo qhov txhab pob txuv, thiab nws tau ua zoo thaum siv ob zaug ib hnub. Qhov tshwm sim ntawm daim tawv nqaij feem ntau yog erythema me me.

Tsis muaj cov xwm txheej tsis zoo uas cuam tshuam txog kev kho mob tau sau tseg thaum mus sib hais; cov tawv nqaij hauv zos (yog tias muaj) zoo ib yam rau cov khoom siv, feem ntau me me. Kev nyab xeeb ntawm cov tshuaj tau lees paub hauv kev qhib daim ntawv lo kev nyab xeeb, uas nthuav dav thaj tsam ntawm cov tshuaj kom suav nrog lub ntsej muag thiab lub cev. Lub sijhawm thov tshuaj ntev thiab kev pab them nqi tsis tau nce qhov tshwm sim ntawm cov kev mob tshwm sim tseem ceeb.