Teva thiab MODAG tau mus txog qhov tshwj xeeb thoob ntiaj teb daim ntawv tso cai: kev txhim kho ntawm aggregation inhibitor anle138b

Teva Pharma thiab MODAG GmbH tsis ntev los no tshaj tawm tias lawv tau mus txog kev koom tes nrog kev koom tes tshwj xeeb rau kev tso cai thoob ntiaj teb thiab kev txhim kho ntawm MODAG GmbH' s lead compound anle 138 thiab lwm yam compound sery433. anle138b tsom rau cov kab mob pathological α-synuclein (α-syn) oligomers, thiab tam sim no ntsuas nws cov peev xwm kho cov kab mob hauv cov neeg mob uas muaj kab mob neurodegenerative. Raws li cov ntsiab lus ntawm daim ntawv cog lus thiab tseem tos daim ntawv tso cai, Teva yuav tau txais daim ntawv tso cai thoob ntiaj teb tshwj xeeb los tsim, tsim thiab ua lag luam anle138b thiab sery433.

Raws li kev tshawb fawb soj ntsuam thaum ntxov, ob tog yuav sib koom ua ke tsim cov tshuaj sib xyaw no rau kev kho mob ntau yam kab mob atrophy (MSA) thiab Parkinson' tus kab mob (PD) qhia, thiab xav txog kev tshawb fawb ntxiv raws li cov txiaj ntsig kho mob. Tam sim no, nws ntseeg tau hais tias lub pathological feature ntawm MSA yog qhov tsub zuj zuj ntawm glial cell khoom hu ua α-synuclein (α-syn) ua rau muaj kev hloov pauv pathological. Qhov pib ntawm PD kuj yog ib qho ntxiv ntawm alpha-synuclein. Yog li ntawd, ob kab mob no yuav muaj qee qhov kev sib txuas.

anle138b yog ib hom tshiab, qhov ncauj, lub hlwb permeability, protein oligomer modulator thiab aggregation inhibitor, nyob rau hauv high-throughput ntsuam xyuas ntawm α-synuclein (α-syn) thiab prion protein (PrP (Sc)) oligomers Me molecule inhibitors tau tshawb pom nyob rau hauv cov txheej txheem. . anle138b tuaj yeem tiv thaiv kev tsim ntawm pathological aggregates ntawm prion protein (PrP(Sc)) thiab α-synuclein (α-syn), muaj qhov ncauj bioavailability zoo, ntshav-hlwb barrier permeability, thiab tsis muaj tshuaj toxicity.

anle138b cov qauv tshuaj

Tam sim no, qhov sib xyaw ua ke tau tsim los rau kev kho mob ntau yam kab mob atrophy (MSA) thiab Parkinson' tus kab mob (PD), uas tau nce zuj zus hauv synucleosis. Nws kuj muaj peev xwm siv tau rau lwm cov synucleocytopathies, xws li dementia nrog Lewy lub cev (DLB). anle138b qhia txog kev kho tshiab rau kev txo cov kab mob hauv cov kab mob neurodegenerative (xws li prions, Parkinson' tus kab mob, thiab lwm yam).

Kev kawm theem 1 los ntsuas anle138b hauv cov neeg ua haujlwm noj qab haus huv tau ua tiav thaum Lub Xya Hli 2020 (NCT04208152) tau pom tias ntawm txhua qib, anle138b muaj cov txiaj ntsig zoo-kev pheej hmoo, thiab qib plasma siab dua hauv cov qauv tsiaj rau kev kho kom tiav Cov qib ntshav plasma yuav tsum tau ua. nyhuv. anle138b yog Ameslikas tsim nyob rau hauv cov neeg mob nrog MSA thiab PD, thiab tej zaum yuav siv tau rau lwm yam kab mob neurodegenerative, xws li Alzheimer' s kab mob (AD). A theem 1b (NCT04685265) kev sim tshuaj ntsuam xyuas tam sim no tab tom ua los ntsuas kev nyab xeeb thiab kev ua tau zoo ntawm cov khoom sib xyaw hauv cov neeg mob PD.

Hafrun Fridriksdottir, Tus Lwm Thawj Coj Thawj Coj ntawm Teva Ntiaj Teb R& D, tau hais tias: "Teva muaj lub hauv paus tseem ceeb ntawm kev txawj ntse hauv neuroscience, neurology thiab psychiatry. Daim ntawv tso cai thiab daim ntawv cog lus kev koom tes no ntxiv ib qho kev cog lus tshiab rau peb cov kav dej thaum ntxov. Cov tshuaj muaj peev xwm coj tau kev xaiv tshiab rau cov neeg mob uas muaj ntau yam kab mob atrophy thiab Parkinson tus kab mob. Peb zoo siab heev los koom tes nrog pab pawg MODAG thiab tos ntsoov rau kev txhim kho yav tom ntej los tshawb txog lwm yam kev qhia rau ob qho kev sib koom ua ke."