STM: Kev hloov kho caj ces ntawm cov qia hlwb tuaj yeem txhim kho ntshav qab zib

Raws li kev tshawb nrhiav tsis ntev los no, cov kws tshawb fawb siv cov hlwb ua los ntawm daim tawv nqaij ntawm tus neeg mob tsis tshua muaj insulin - cov ntshav qab zib mellitus (kab mob Wolfram syndrome) ua rau cov ntshav pluripotent qia thiab hloov mus ua insulin - cov qe ntshav. Cov cuab yeej kho kom zoo CRISPR - Cas9 kho cov caj ces mob uas ua rau muaj mob. Lawv mam li cog cov hlwb no hauv cov nas thiab kho cov nas & # 39; s mob ntshav qab zib.

Cov kev tshawb fawb no los ntawm cov kws tshawb fawb hauv Tsev Kawm Ntawv University of Washington hauv Tsev Kawm Ntawv Tshuaj hauv St. Louis qhia tias CRISPR - Cas9 thev naus laus zis tuaj yeem ua lub zog tshaj lij rau kev kho mob ntshav qab zib, tshwj xeeb tshaj yog ntshav qab zib tshwm sim los ntawm ib qho kev hloov noob. Cov kev tshawb fawb tau luam tawm online nyob rau hauv phau ntawv xov xwm Science Translational Medicine thaum lub Plaub Hlis 22.

(Yees duab los ntawm: Www.pixabay.com)

Cov neeg mob uas muaj Wolfram syndrome pib mob ntshav qab zib thaum menyuam yaus lossis thaum tiav hluas, thiab xav tau kev hloov tshuaj insulin sai sai, yuav tsum tau txhaj tshuaj insulin ntau hnub. Cov neeg mob feem ntau ntsib teeb meem tsis pom kev thiab sib npaug thiab lwm yam teeb meem. Hauv ntau cov neeg mob, tus mob yuav ua rau muaj kev tuag ntxov.

& quot; Nov yog thawj zaug uas CRISPR tau siv los kho cov ntshav qab zib los ntawm kev tshuaj ntsuam caj ces, & quot; hais tias co - tus kws tshawb nrhiav Dr. Jeffrey R. Millman, uas yog ib tug pab cuam kws tshuaj thiab tshuaj lom neeg lub tsev kawm ntawv qib siab hauv University Washington.

Cov kab mob Wolfram yog tshwm sim los ntawm kev hloov pauv hauv ib tus noob tib, yog li cov kws tshawb nrhiav vam tias yuav nkag siab tias los ntawm kev sib txuas ntawm cov cell cell technology nrog CRISPR, mob ntshav qab zib los ntawm kev hloov pauv tuaj yeem kho tau.

Ob peb xyoos dhau los, Millman thiab cov npoj yaig tau pom yuav ua li cas hloov tib neeg cov qia hlwb ua rau pancreatic beta cells. Cov kws tshawb nrhiav tau tsim kho cov thev naus laus zis tshiab uas tuaj yeem hloov kho tib neeg lub hlwb mus ua cov qe ntshav beta, uas muaj cov txiaj ntsig zoo los tswj cov ntshav qab zib.

Hauv txoj kev tshawb nrhiav no, lawv tau siv sijhawm ntxiv los mus rho cov hlwb no los ntawm cov neeg mob thiab siv CRISPR - Cas9 gene kho cov cuab yeej ntawm cov hlwb no los kho cov kev hloov caj ces uas ua rau Wolfram syndrome (WFS1). Cov kws tshawb nrhiav tom qab muab cov noob - kho tawm cov hlwb nrog insulin - tso tawm cov qe hlwb sib txawv ntawm cov qub ntawm cov qia hlwb uas tsis tau kho nrog CRISPR.

Tus kws sau cog lus CRISPR - kho cov hlwb rau cov ntshav qab zib uas yog los ntawm cov hlav ntshav tsis xws luag. Cov txiaj ntsig pom tau tias cov ntshav qab zib sai sai ploj, thiab cov tsiaj cov ntshav qab zib cov ntshav yuav nyob li qub thoob plaws rau lub hlis ntawm kev tshuaj xyuas. Nyob rau hauv ntau. Hauv kev sib piv, cov nas uas tau txais cov tsis muaj ntshav beta tseem tuaj yeem muaj ntshav qab zib.

In the future, using CRISPR to correct certain mutations in beta cells may help those with diabetes caused by multiple genetic and environmental factors. & quot;We are excited that we are able to combine these two technologies and use CRISPR to correct genetic defects, & quot; Millman said. & quot;In fact, we found that the corrected beta cells are no different from those derived from the stem cells of healthy people without diabetes. & quot;

Cov kws tshawb nrhiav tau hais tias yav tom ntej, cov txheej txheem ua β cov hlwb los ntawm cov qia hlwb yuav tsum ua kom yooj yim dua. Piv txwv li, cov kws tshawb fawb tau tsim kho txoj hauv kev tsawg dua los ua kom cov qia hlwb ntshav tawm los ntawm cov ntshav - lawv tau ua haujlwm los tsim cov qia hlwb los ntawm kev tso zis. (los ntawm Bioon.com)