Cov xwm txheej ntawm β-lactams

Tom qab ze li ntawm 50 xyoo ntawm kev txhim kho, β-lactam cov tshuaj tua kab mob tau tsim ib qho kev ua tiav tiav. Yuav luag txhua yam antibiotics-lactam cov tshuaj tua kab mob (tshwj tsis yog cov ntau yam hauv lub sijhawm ua si muaj cai) tuaj yeem tsim nyob hauv Suav teb, thiab tus nqi qis heev. Kev tsim cov tshuaj penicillin yog nyob rau hauv txoj hauj lwm saum toj kawg nkaus hauv lub ntiaj teb, thiab coob tus xa khoom xa tawm mus rau lub thoob ntiaj teb. Cov tshuaj tua kab mob cephalosporin yog qhov txaus nws tus kheej. Yuav tuaj yeem sib ntaus sib tua ib feem ntawm kev xa tawm.

Txhua cov tshuaj nruab nrab ua ke nrog antibiotics-lactam cov tshuaj tua kab mob tuaj yeem tsim tawm ntawm peb tus kheej. Tsuas yog suav cov ntsaws ib nrab ntawm cov tshuaj tiv thaiv ib nrab hluavtaws, 7-ACA thiab 7-ADCA, txhua qhov ntawm cov saw sab ib nrab yuav tuaj yeem tsim thiab xa tawm hauv ntau ntau.

Noj phenylacetic acid, lub ntsiab lus nruab nrab ntawm cov tshuaj tua kab mob β-lactam, piv txwv li, muaj ze li 30 phenylacetic acid tsim nyob rau hauv Suav nrog tag nrho txhua xyoo kev tsim muaj peev xwm ntawm txog 20,000 tons. Txawm li cas los xij, feem ntau cov tuam txhab lag luam me me hauv qhov loj me, nrog qhov loj tshaj plaws txhua xyoo tsim tawm ntawm 2,000 tons, thiab lwm qhov loj loj nyob rau hauv ntau xyoo ntawm ntau pua pua tons. Hauv 2003, tag nrho cov kev thov hauv tebchaws rau phenylacetic acid yog li ntawm 14,000 tons. Tus qauv noj yog: penicillin G lees paub txog 85%, lwm yam tshuaj muaj txog 4%, cov tshuaj tsw qab muaj 7%, thiab cov tshuaj tua kab thiab lwm cov teb muaj txog 4%.

Nrog rau kev txhim kho cov txuj lom hauv tsev, tshuaj, tshuaj tua kab thiab lwm yam kev lag luam, qhov kev thov rau phenylacetic acid yuav nce ntxiv. Nws kwv yees tias los ntawm 2005, Tuam Tshoj txoj kev lag luam kws tshuaj yuav haus txog 14,000 tons ntawm phenylacetic acid, kev lag luam tshuaj tua kab yuav haus 500 tons, thiab kev lag luam txuj lom yuav haus txog 2,000 tons. Ua ke nrog kev noj nyob rau hauv lwm cov haujlwm, kev xav tau tag nrho hauv tebchaws rau phenylacetic acid yuav tsum ncav 18,000 tons hauv 2005.