Sihuan Cov Khoom lag luam txais tag nrho cov cai thiab cov cuab yeej fwm cai ntawm Zemdri (plazomicin) hauv Greater Suav Teb!

Sihuan Pharmaceutical Holdings Group Co., Ltd. tau tshaj tawm tsis ntev los no hais tias nws tau txais tag nrho cov cai thiab cov cuab yeej fwm kev cai ntawm tiam tshiab ntawm aminoglycoside tshuaj tua kab mob Zemdri (plazomicin) hauv Greater China cheeb tsam (Mainland, Hong Kong, Macau, Taiwan) los ntawm Asmeskas chaw tsim tshuaj kev lag luam Achaogen.

Plazomicin yog lub sijhawm tshiab ntawm cov tshuaj tiv thaiv ib nrab ntawm aminoglycoside tsim los ntawm Achaogen. Nws tsuas yog inhibits kev txhais cov txheej txheem ntawm cov kab mob protein los ntawm kev sib txuas nrog cov kab mob ribosomal 30S subunit, yog li ua cov kab mob bacteriostatic. Plazomicin raug hloov kho tshuaj raws kev sisomicin, uas tuaj yeem zam kom tsis txhob raug rhuav tshem los ntawm aminoglycoside tseem ceeb tshuaj tua kab mob deactivation enzyme (AME) thiab plam nws cov haujlwm. plazomicin tau tsim kho rau kev kho mob rau cov mob hnyav los ntawm multidrug tsis kam (MDR) Cov kab mob Gram-negative Enterobacteriaceae, suav nrog Enterobacteriaceae tiv taus cov tshuaj tua kab mob carbapenem.

Hauv Suav Teb, cov kab mob MDR feem ntau kis hauv tsev kho mob, thiab feem ntau ntawm cov neeg mob yog cov tsis muaj kev tiv thaiv qis los ntawm ntau yam. Cov kab mob zoo li kab mob tshiab coronavirus yuav ua mob tawm rau lymphocytes thiab rhuav tshem lub cev' s tiv thaiv kab mob. Thaum lub cev' s tiv thaiv kab mob tsawg dua, cov kab mob kis kab mob theem ob yuav tshwm sim, muaj feem ntau ntawm kev kis mob hauv tsev kho mob.

Cov tshuaj muaj rau cov kab mob MDR hauv kev kho mob hauv tsev kho mob muaj tsawg tsawg, tab sis tsuas yog qee txoj kev kho tau txwv kev siv tshuaj vim kev mob raum tsis zoo thiab lwm yam teeb meem. Lub Rau Hli 2018, txhaj tshuaj plazomicin (hom npe: Zemdri) tau pom zoo los ntawm Tsoom Fwv Tswj Khoom Noj thiab Tshuaj (FDA) rau kev kho cov mob txeeb zig ua ke (cUTI) thiab mob pyelonephritis mob siab rau cov neeg laus. Tam sim no, cov ntawv thov soj ntsuam tau lees paub tias qhov kev pheej hmoo ntawm nephrotoxicity ntawm plazomicin yog qis dua li ntawm cov tiam dhau los ntawm aminoglycoside tshuaj.

FDA tau pom zoo txhaj plazomicin raws li cov ntaub ntawv los ntawm Ntu III EPIC kawm. Qhov no yog thawj zaug kev kawm txog kev soj ntsuam los soj ntsuam ib zaug-txhua hnub cov tshuaj aminoglycoside rau cUTI (suav nrog pyelonephritis). Lub hom phiaj tseem ceeb kawg ntawm txoj kev tshawb no yog: kev kho cov kab mob sib kis tau yooj yim los kho (mMITT, n = 388) pab pawg hnub 5 thiab mus ntsib kho mob (kuaj-ntawm-kho, TOC, hnub 17 + 2) (kho mob thiab kev tshem tawm cov kab mob me).

Cov ntaub ntawv qhia tias plazomicin piv rau meropenem: (1) Qhov sib xyaw ua kom zoo ntawm hnub thib tsib ntawm kev kho mob yog 88.0 (168/191) hauv pawg Zemdri thiab 91.4% (180/197) hauv pawg meropenem (qhov txawv: - 3.4%, 95% CI: -10.0, 3.1). (2) Qhov sib xyaw ua kom zoo ntawm TOC lub sijhawm yog 81.7 (156/191) hauv pawg Zemdri thiab 70.1% (138/197) hauv pawg meropenem (qhov txawv: 11.6%, 95% CI: 2.7, 20.3). (3) Ntawm cov neeg mob bacteremia ntawm lub hauv paus, qhov sib koom ua kom zoo ntawm TOC lub sijhawm yog 72.0 (18/25) hauv pawg Zemdri thiab 56.5% (13/23) hauv pawg meropenem. Hauv kev tshawb nrhiav, qhov xwm txheej tshwm sim ntau tshaj plaws (tshwm sim hauv ≥1% ntawm Zemdri-kho cov neeg mob) tau txo lub raum tsis ua haujlwm, mob raws plab, kub siab, mob taub hau, xeev siab, ntuav, thiab ntshav siab.

Ntxiv rau kev nrhiav tau ntawm plazomicin, chav kawm tshiab ntawm lub carbapenem broad-spectrum tshuaj tua kab mob" Binapenem" kev ywj pheej tsim los ntawm Sihuan Pharmaceutical Holdings Group, nws theem II kev soj ntsuam kuaj mob rau mob txeeb zig ua rau ntau qhov chaw kuaj mob hauv Suav teb tau ua thiab tau ua haujlwm zoo. Nws yuav tsum nkag mus rau theem III kev soj ntsuam hauv tsev kho mob lub sijhawm thib ob ntawm lub xyoo no. Lwm qhov tshuaj los tiv thaiv kev sib kis ntawm cov pab pawg," azithromycin tsiav tshuaj", npaj yuav raug xaiv los ua cov pawg thib ob ntawm lub teb chaws cov tshuaj rau kev ua haujlwm nruab nrab. Cov khoom xa tuaj hauv xeev ntawm cov tshuaj yog Jiangsu, Shandong, Fujian, Liaoning, Heilongjiang, Gansu, Guangxi thiab Tibet, thiab yuav muab tsawg kawg 30 lab ntsiav tshuaj ntawm cov tshuaj.

Dr. Che Fengsheng, Tus Thawj Coj thiab Tus Thawj Coj ntawm Sihuan Pharmaceutical Holdings Group tau hais tias:" Raws li cov kab mob txuas ntxiv tiv thaiv cov tshuaj tua kab mob uas twb muaj lawm, cov kab mob super tau dhau los ua kev phom sij tshaj plaws rau tib neeg. Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv kwv yees hais tias los ntawm 2050 10 lab tib neeg tau tuag los ntawm tus kab mob super kab mob. Txheeb xyuas Pharma, lub koom haum kev tshawb fawb txog kev lag luam tshuaj, kwv yees tias plazomicin kev muag khoom txhua xyoo yuav nce mus txog $ 313 lab nyob rau xyoo 2022. Tom qab tau teev npe hauv Greater Tuam Tshoj, pab pawg cia siab tias plazomicin yuav tau txais txiaj ntsig kev lag luam ntau ntxiv, kev xaiv ntawm azithromycin capsules hauv ob batch ntawm lub teb chaws nruab nrab cov kev yuav tshuaj yuav pab cov pab pawg azithromycin tsiav tshuaj kom sai qhib cov kev muag khoom hauv tsev muag hauv Suav teb, nce kev lag luam, thiab yuav txhawb ntxiv kev loj hlob sai sai ntawm pab pawg hauv cov tshuaj tiv thaiv kev kis mob.

Sihuan Pharmaceutical Holdings Group Co., Ltd. tau tsim nyob rau xyoo 2001. Nws yog cov pab pawg tshuaj lag luam nrog 21 lub chaw pabcuam thiab kev sib xyaw R& D, ntau lawm thiab muag khoom. Vim tias muaj ntau tshaj li kaum xyoo ntawm kev siv zog tas mus li thiab muaj kev nqis peev ntau hauv kev tshawb nrhiav thiab kev tsim kho, Sihuan Pharmaceutical tau tsim pab pawg tshawb fawb thiab kev tsim kho ze li ntawm 1,000 tus neeg, muaj ntau tshaj li 110 txoj haujlwm tshuaj nyob hauv kev tsim kho, thiab tau txais ntau dua 300 tawm lub teb chaws tsim tshuaj tshiab. , ntawm uas ntau dua 80 Thov rau txawv teb chaws patent cov cai. Cov phiaj xwm kev tshawb fawb tsuas yog siv rau ntau qhov tseem ceeb xws li mob ntshav qab zib, tiv thaiv qog, tiv thaiv mob thiab tsis muaj kab mob cawv. (Bioon.com)