Paclitaxel liposomes muaj kev ua tau zoo hauv kev siv tshuaj tua kab mob tiv thaiv kab mob rau kev mob ntsws cancer siab.

Nyob rau hauv xyoo tas los no, kev kho mob qog noj ntshav thoob ntiaj teb tau ua rau muaj kev cuam tshuam zoo, tshwj xeeb tshaj yog nyob rau hauv kev mob qog noj ntshav. Nrog rau kev cuam tshuam ntawm kev siv tshuaj tiv thaiv kab mob thiab cov phiaj xwm kho mob, lub sijhawm nruab nrab ntawm kev ciaj sia ntawm cov neeg mob uas mob qog noj ntshav siab tau zoo tuaj. Txawm li cas los xij, cov neeg mob qog noj ntshav uas tsis yog me me uas muaj cov noob tsav tsheb tsis zoo tseem suav rau feem coob ntawm cov neeg mob qog noj ntshav siab. Vim qhov nyuaj ntawm tus kab mob, cov neeg mob tau txwv cov txiaj ntsig kev ciaj sia los ntawm kev siv tshuaj tiv thaiv kab mob.

Nyob rau ntawm CSCO Satellite Conference on Advanced Lung Cancer Immunization and Chemotherapy, ntau tus kws paub txog qog nqaij hlav tau ua ntau qhov kev sib tham txog kev kho mob ntawm cov qog nqaij hlav qog nqaij hlav tsis zoo (NSCLC) hauv cov neeg mob uas muaj cov noob tsis zoo. Lub rooj sib tham tau tuav los ntawm Xib Fwb Qin Shukui, tus kws kho mob tseem ceeb ntawm Cancer Center ntawm Jinling Tsev Kho Mob ntawm Eastern Theatre Command, thiab xibfwb Han Baohui, tus kws kho mob tus thawj coj ntawm Lub Tsev Haujlwm Saib Xyuas Kev Ua pa ntawm Shanghai Chest Tsev Kho Mob. Xya tus kws tshaj lij thiab cov kws tshawb fawb los ntawm Beijing, Shanghai, Suzhou, thiab Xi' ib qho koom nrog hauv tsab ntawv tshaj tawm thiab kev sib tham. .

Kev txhaj tshuaj ua ke nrog kev kho tshuaj khomob tseem yog tus qauv xaiv rau NSCLC siab heev

Xibfwb Zhou Caicun, tus kws kho mob ntawm Shanghai Pulmonary Hospital koom nrog Tongji University, thiab xibfwb Mu Xinlin, tus kws kho mob ntawm Kev Ua pa thiab Kev Kho Mob Tseem Ceeb ntawm Peking University People' Tsev Kho Mob raws li qhia txog qhov kev txhim kho tshiab kawg hauv kev kho mob ntawm mob ntsws cancer siab heev.

Xib fwb Zhou Caicun tau hais tias hauv kev sim tshuaj, thawj kab tshuaj tiv thaiv kab mob tau txhim kho lub sijhawm muaj sia nyob ntawm cov neeg mob uas muaj NSCLC siab heev, thiab kev siv tshuaj tiv thaiv kab mob lossis kev tiv thaiv kab mob sib xyaw ua ke tau dhau los ua kev kho mob niaj hnub. Cov txiaj ntsig ntawm kev tshawb fawb hauv ntiaj teb tiag tiag ntawm kev tiv thaiv kab mob loj tshaj plaws hauv thawj kab kev kho mob ntawm NSCLC qib siab txog tam sim no qhia tau tias kev kho tshuaj tiv thaiv kab mob thiab kev tiv thaiv kab mob monotherapy tau zoo rau qib NSCLC, tab sis lawv tau txais txiaj ntsig tsawg dua li kev tshawb fawb soj ntsuam hauv ntiaj teb tiag. Ntawm lawv, cov ntsiab lus tseem ceeb cuam tshuam rau cov nyhuv ntawm kev tiv thaiv kab mob monotherapy yog PS qhab nia thiab lub hlwb metastasis, thiab qhov sib txawv ntawm cov nyhuv ntawm lub hlwb metastasis ntawm cov txiaj ntsig tau nce mus txog 6 zaug. Ntawm qhov tsis sib xws, tus neeg mob lub hnub nyoog thiab kev qhia PD-1 muaj qhov cuam tshuam tsis zoo rau qhov ua tau zoo.

Xib Fwb Mu Xinlin tau hais hauv tsab ntawv tshaj tawm hu ua" Kev nce qib hauv Kev Kho Mob Tsis Zoo Ntawm Cov Kab Mob ntsws me me los ntawm Kev txhaj tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob", txoj kev kho mob ntsws cancer tau dhau los ua ntau haiv neeg, thiab kev siv tshuaj khomob tseem yog ib qho. lub hauv paus tseem ceeb ntawm kev kho mob ntsws cancer." Kev tiv thaiv kab mob monotherapy yog xaiv rau cov neeg uas tau txais txiaj ntsig los ntawm kev mob qog noj ntshav siab. Cov neeg uas muaj PD-1 siab qhia yuav tau txais txiaj ntsig zoo, thiab cov neeg uas tsis tshua muaj PD-1 qhia yuav tsis tau txais txiaj ntsig zoo, thiab nws' tsis zoo dua li kev kho mob."

Tam sim no, NCCN cov lus qhia tau siv cov tshuaj tiv thaiv kab mob sib xyaw ua ke ua ib hom pov thawj rau kev kho mob ntsws cancer siab heev, suav nrog ntsws adenocarcinoma thiab ntsws squamous cell carcinoma. Nws txoj kev ua tau zoo thiab kev nyab xeeb tau raug pov thawj los ntawm ntau theem peb cov kev tshawb fawb soj ntsuam xws li KEYNOTE-407, RATIONAEL307, KEYNOT189, Impower130, thiab Impower150.

Cov kev tshawb fawb RCT loj qhia tau hais tias paclitaxel liposomes muaj kev txhim khu kev qha thiab kev nyab xeeb

Ntawm ntau cov kws khomob khomob, paclitaxel liposome tau dhau los ua kev xaiv tshuaj khomob zoo tshaj plaws hauv kev mob qog noj ntshav vim nws lub hom phiaj tshwj xeeb.

Thaum Lub Kaum Hli 26, cov ntawv pov thawj ntawm Cancer Communications (IF: 10.393) tau luam tawm ntau lub chaw, randomized, qhib, sib txuas tswj kev soj ntsuam kev tshawb fawb coj los ntawm Xib Fwb Zhou Caicun-Lipusu® (paclitaxel liposome) rau kev kho mob ntawm theem siab loj RCT kev tshawb fawb ntawm mob ntsws squamous cell carcinoma (LIPUSU txoj kev tshawb fawb). Txoj kev tshawb no tau muab piv rau kev ua tau zoo thiab kev nyab xeeb ntawm paclitaxel liposomes ua ke nrog cisplatin (LP) thiab gemcitabine ua ke nrog cisplatin (GP) hauv thawj kab kev kho mob ntawm lub ntsws squamous cell carcinoma. Cov txiaj ntsig tau pom tias cov nyhuv curative ntawm LP hauv thawj kab kev kho mob ntawm cov mob ntsws squamous cell carcinoma zoo ib yam li GP, nrog qhov nruab nrab PFS (5.2m) p> 0.05; OS nyob rau hauv pab pawg LP yog 2.1 lub hlis ntev dua li hauv pawg GP (14.6m vs 12.5m), hais txog ORR thiab DCR hauv ob pawg Tsis muaj qhov sib txawv tseem ceeb tag nrho (p> 0.05). Hais txog kev nyab xeeb, tag nrho cov xwm txheej ntawm ob pawg tau zoo sib xws. Tag nrho (> 30%) cov xwm txheej tsis zoo (tshwj tsis yog cov plaub hau poob) hauv pawg LP tau qis dua cov hauv pawg GP (p< 0.01),="" thiab="" ntau="" qib="" 3-5="" cov="" xwm="" txheej="" tsis="" zoo="" tshwm="" sim.="" hauv="" pawg="" gp="" cov="" xwm="" txheej="" xws="" li="" qib="" 3-5="" anemia="" (31.2%="" vs="" 14.3%,="">< 0.0001)="" thiab="" platelet="" poob="" (14.1%="" vs="" 1.5%,="">< 0.0001).="" qhov="" feem="" pua="" ​​​​ntawm="" cov="" tshuaj="" raug="" ncua="" lossis="" kev="" txiav="" tawm="" vim="" yog="" qhov="" tshwm="" sim="" tsis="" zoo="" lossis="" qhov="" tshwm="" sim="" tsis="" zoo="" hauv="" pawg="" lp="" tau="" qis="" dua="" li="" ntawm="" pawg="">

Lwm qhov kev rov qab los, ntau qhov chaw, ib sab caj npab, tsis muaj kev cuam tshuam hauv ntiaj teb txoj kev tshawb fawb soj ntsuam kev ua tau zoo thiab kev nyab xeeb ntawm PD-1 monoclonal antibody ua ke nrog paclitaxel liposomes hauv kev kho mob ntsws squamous cell carcinoma thiab ntsws adenocarcinoma hauv ntiaj teb tiag. Txoj kev tshawb no tau sau cov neeg mob uas mob ntsws squamous cell carcinoma lossis ntsws adenocarcinoma kho nrog paclitaxel liposome nrog PD-1 monoclonal antibody los ntawm rooj plaub ntawm Peking University People's Hospital, Jiangsu Provincial People's Hospital, thiab Shandong University Qilu Tsev Kho Mob los ntawm 2016 txog 2021. cov ntaub ntawv.

Cov txiaj ntsig tau pom tias" paclitaxel liposome ua ke nrog PD-1 monoclonal antibody pom tias muaj txiaj ntsig zoo hauv kev kho mob ntsws squamous cell carcinoma thiab ntsws adenocarcinoma. Qhov nruab nrab PFS ntawm tag nrho cov pejxeem yog 9.2 lub hlis, ntawm qhov nruab nrab PFS ntawm squamous cell carcinoma pejxeem yog 9.8 Lub Hlis, qhov nruab nrab PFS ntawm cov neeg mob adenocarcinoma yog 9.2 lub hlis, thiab tsis muaj qhov sib txawv. Kev nyab xeeb ntawm kev sib xyaw ua ke yog kev zam, thiab feem ntau ntawm lawv yog qib 1-2 qhov kev phiv tshwm sim, thiab tsis pom qhov tshwm sim tsis zoo tshiab." Xibfwb Mu Xinlin Express.

Paclitaxel liposomes tau suav nrog hauv kev pov hwm kho mob, thiab bevacizumab yog tus khub tsiaj qus.

Ntawm lub rooj sib tham satellite, tsib tus kws tshaj lij kuj tau sib tham tob txog kev siv tshuaj kho mob qog noj ntshav, tshwj xeeb yog paclitaxel.

Xib fwb Shu Yongqian los ntawm Cancer Center ntawm Jiangsu Provincial People' s Tsev Kho Mob tau hais tias koob tshuaj kho mob rau lub ntsws squamous cell carcinoma muaj feem xyuam rau thaj tsam ntawm lub cev. Kev lag luam muaj liposomal paclitaxel 30mg / lub raj mis, tuaj yeem kho raws li tus neeg mob' lub cev zoo li qub. Cov koob tshuaj yog ib qho yooj yim los kho thiab tswj, thiab nws yog qhov kev xaiv zoo tshaj plaws rau cov neeg Suav, tshwj xeeb tshaj yog rau cov neeg laus. Tsis tas li ntawd, pretreatment ntawm liposomal paclitaxel yog qhov yooj yim. Kev sib xyaw ua ke ntawm PD-1 thiab lwm yam tshuaj muaj txiaj ntsig zoo hauv tsev kho mob, thiab tsis ua rau muaj qhov tsis zoo ntawm tus neeg mob.

Xib fwb Hu Xingsheng los ntawm Cancer Institute ntawm Suav Academy ntawm Kev Kho Mob Sciences ntseeg hais tias txawm hais tias txoj kev loj hlob ntawm immunotherapy yog nyob rau hauv tag nrho viav vias, los ntawm kev soj ntsuam, cov nyhuv ntawm kev tiv thaiv kab mob monotherapy nyob rau hauv kev kho mob ntawm lub ntsws cancer yog tseem txwv, thiab tsuas muaj zoo. Cov ntaub ntawv muaj sia nyob rau cov neeg uas muaj PD-1 qhia ntau dua 50%. Cov neeg mob uas PD-1 qhia tsawg dua 50% tseem yuav tsum tau siv tshuaj tiv thaiv kab mob ua ke nrog tshuaj kho mob.

Xib fwb Ren Shengxiang los ntawm Department of Oncology, Shanghai Pulmonary Hospital koom nrog Tongji University, tau hais tias rau kev mob qog noj ntshav siab, txawm tias adenocarcinoma lossis squamous cell carcinoma, kev siv tshuaj tiv thaiv kab mob ua ke tau dhau los ua kev kho mob thawj zaug. Tam sim no, liposomal paclitaxel tau pom zoo rau kev kho mob ntawm cov qog nqaij hlav tsis me me hauv lub ntsws, mob qog noj ntshav ntawm zes qe menyuam thiab mob qog noj ntshav, thiab suav nrog cov kev pov hwm kho mob hauv tebchaws, uas txo qis nyiaj txiag lub nra ntawm cov neeg mob qog noj ntshav thiab txhim kho kev muaj. tshuaj.

& quot; Lub luag haujlwm ntawm cov tshuaj tiv thaiv kab mob tiv thaiv kab mob hauv kev kho mob NSCLC siab heev nrog cov noob tsis zoo tsav tsheb tau tsim. Txawm hais tias nws yog squamous cell carcinoma lossis adenocarcinoma, txawm hais tias PD-1 tau qhia los yog tsis, paclitaxel liposomes ntxiv rau cov tshuaj siv tshuaj platinum ua ke nrog kev tiv thaiv kab mob tiv thaiv Txhua tus neeg sawv cev tau pom zoo los ntawm CSCO cov lus qhia (Cov pov thawj Class 1A). hais tias xibfwb Chen Kai los ntawm Department of Oncology, First Affiliated Hospital of Soochow University.

Hais txog tus nqi ntawm bevacizumab nyob rau hauv advanced non-squamous NSCLC, xibfwb Yao Yu, tus kws kho mob ntawm Thawj Tsev Kho Mob ntawm Xi'an Jiaotong University, ntseeg hais tias cov tshuaj anti-angiogenic bevacizumab muaj keeb kwm ntawm ntau tshaj kaum xyoo hauv kev kho mob daim ntawv thov thiab tau ua Cov txheej txheem pom zoo kom muab cov tshuaj tua kab mob, cov tshuaj tsom, thiab tshuaj tiv thaiv kab mob rau thawj kab kev kho mob ntawm qib siab uas tsis yog-squamous NSCLC. Nws tau piav qhia," Bevacizal zoo li tus khub uas muaj ntau yam, thiab nws tau ua haujlwm zoo nrog kev kho mob, kev tiv thaiv kab mob, thiab lub hom phiaj."