Emopamil binding protein (EBP) inhibitor DSP-0390 nkag mus rau thawj theem 1 kev sim tshuaj rau tib neeg!

Sumitomo Dainippon Pharma Oncology, lub tuam txhab ua lag luam tag nrho ntawm Sumitomo Dainippon Pharma, lub tuam txhab tshuaj Japanese, tsis ntev los no tau tshaj tawm tias thawj tus neeg mob tau raug tswj hwm nyob rau theem 1 kev tshawb fawb soj ntsuam (NCT0502351) tshuaj ntsuam xyuas cov tshuaj DSP-0390 nyob rau hauv kev tshawb nrhiav. DSP-0390 yog ib qho emopamil binding protein (EBP) inhibitor rau kev kho mob ntawm cov neeg mob uas rov muaj dua qib siab glioma.

High-grade glioma yog hom mob qog nqaij hlav hauv hlwb feem ntau, uas tuaj yeem ua rau mob hnyav thiab tuag taus. Cov kev tshawb fawb ua ntej tau pom tias DSP-0390 tuaj yeem muaj kev tiv thaiv qog nqaij hlav thiab pab daws qhov kev xav tau kev kho mob mus ntev.

Txoj kev tshawb no theem 1 yog thawj tus tib neeg, qhib-daim ntawv sau npe, kev tshawb fawb txog koob tshuaj, thiab nws lub hom phiaj tseem ceeb yog ntsuas kev nyab xeeb thiab kev zam ntawm DSP-0390 hauv cov neeg mob uas muaj qib siab glioma. Qhov kev sim kuj tseem yuav txiav txim siab qhov siab tshaj plaws uas tau txais koob tshuaj (MTD) thiab / lossis ncua kev pom zoo koob tshuaj (RDE). Lub hom phiaj thib ob yog piav qhia txog cov tshuaj pharmacokinetic (PK) ntawm DSP-0390.

Tom qab ua tiav cov koob tshuaj nce ntxiv ib feem ntawm qhov kev sim, txoj kev tshawb fawb yuav nkag mus rau qhov txuas ntxiv ntawm Ntu 2 los soj ntsuam seb DSP-0390 puas muaj kev tiv thaiv qog ua ntej thiab txiav txim siab txog kev kho mob ntawm WHO (WHO) qib III lossis IV malignant kua nplaum. pom zoo rau theem 2 koob tshuaj rau cov qog nqaij hlav loj (RP2D).

DSP-0390 yog ib qho emopamil binding protein (EBP) inhibitor thiab tam sim no tab tom kawm theem 1 hauv cov neeg mob uas rov muaj qib siab glioma (NCT0502351). EBP yog endoplasmic reticulum membrane protein koom nrog hauv cov roj cholesterol biosynthesis. Txij li thaum feem ntau cov qog nqaij hlav qog nqaij hlav yog tus cwj pwm los ntawm kev tswj hwm ntawm ntau txoj hauv kev ua lub luag haujlwm rau lawv cov biosynthesis, thiab xav tau cov roj cholesterol los txhawb kev loj hlob ntawm tes.

Yog li, qhov inhibition ntawm EBP los ntawm DSP-0390 yuav tsum ua rau kev puas tsuaj ntawm cov roj cholesterol homeostasis thiab ua rau mob qog noj ntshav tuag. Tsis tas li ntawd, nws tau tshaj tawm tias EBP tau nthuav tawm ntau yam mob qog noj ntshav thiab cuam tshuam nrog kev ua phem ntawm qee yam mob qog noj ntshav. DSP-0390 muaj peev xwm muaj kev tiv thaiv qog nqaij hlav hauv cov qog nqaij hlav no.