CStone Pharmaceuticals thiab Pfizer koom tes txhim kho ntxiv los koom ua ke tsim cov tshuaj kho mob qog noj ntshav tshiab loratinib hauv Suav teb

Thaum Lub Rau Hli 15th, Hong Kong cov khoom lag luam sau npe tshiab cov tuam txhab tshuaj Cornerstone Pharmaceuticals (2616.HK) tshaj tawm tias lub tuam txhab thiab Pfizer yuav koom ua ke tsim cov tshuaj tshiab rau ROS1-zoo mob qog noj ntshav rau cov neeg mob hauv Cheeb Tsam Loj Tuam Tshoj-lorlatinib (lorlatinib). Ob tog' kev tshawb fawb soj ntsuam tom ntej ntawm ROS1 lub hom phiaj hauv Suav teb yuav yog lub ntiaj teb' thawj qhov kev kawm tseem ceeb ntawm loratinib ntawm lub hom phiaj no.

Kev sib koom ua ke muaj zog ntawm kev tshawb fawb tshawb fawb thiab kev txhim kho thiab phiaj xwm kev tshawb fawb

Kev sib koom tes txhim kho kev koom tes ntawm CStone Pharmaceuticals thiab Pfizer yog kev ntxiv dag zog ntxiv ntawm txoj kev koom tes zoo ntawm ob tog txij li xyoo tas los. Thaum lub Cuaj Hlis xyoo tas los, CStone Pharmaceuticals thiab Pfizer tshaj tawm txoj kev koom tes nrog, suav nrog Pfizer US $ 200 lab kev nqis peev nqis peev hauv CStone Pharmaceuticals, CStone kev tso cai ntawm Pfizer los tsim thiab ua lag luam suggliumab hauv Suav teb, thiab CStone Pharmaceuticals thiab Pfizer yuav qhia ntau yam khoom siv oncology rau hauv. lub luag haujlwm ntawm kev koom tes hauv Cheeb Tsam Loj Tuam Tshoj. CStone Pharmaceuticals thiab Pfizer yuav koom ua ke xaiv cov khoom lag luam oncology hauv Pfizer pipeline uas yog nyob rau theem kawg ntawm kev tshawb fawb thiab kev txhim kho (uas tau dhau qhov pov thawj-ntawm-lub tswv yim) thiab sib koom tsim lawv hauv Cheeb Tsam Tuam Tshoj. CStone Pharmaceuticals thiab Pfizer tseem tuaj yeem xaiv koom tes hauv Cheeb Tsam Tuam Tshoj. Qhia lwm cov khoom qog.

Dr. Jiang Ningjun, Tus Thawj Coj thiab CEO ntawm CStone Pharmaceuticals, tau hais tias: "Qhov kev koom tes ntxiv no ua rau pom tau tias Pfizer lees paub CStone Pharmaceuticals 'muaj peev xwm txhim kho kev kho mob. Peb tos ntsoov rau kev sib koom tes zoo nrog Pfizer txhawm rau txhim kho kev ua tau zoo thiab ua tau zoo. Ntau yam khoom kho mob qog nqaij hlav tshiab tau coj tuaj rau feem coob ntawm cov neeg mob."

Pierre Gaudreault, Thawj Tswj Hwm ntawm Pfizer Biopharmaceuticals Group hauv Suav Teb, hais tias:" Qhov kev sib koom ua lag luam tob tob nrog CStone Pharmaceuticals muab rau peb lwm qib hauv kev koom tes. Thoob plaws ntiaj teb, Pfizer muaj ntau yam tseeb ntawm lub hom phiaj kev hloov pauv noob caj noob ces hauv kev mob ntsws ntsws. Cov tshuaj kho mob, thiab muaj kev nkag siab tob txog kev ua lag luam ntawm ALK thiab ROS1 lub hom phiaj. CStone Pharmaceuticals tsom mus rau txoj kev kho qog nqaij hlav qog noj ntshav tshiab thiab tshuaj kho mob kom raug, thiab yuav txhaj tshuaj muaj zog txhim kho kev muaj peev xwm rau hauv kev koom tes no. Peb tos ntsoov rau kev nrawm ntxiv ntawm Laura Kev nyab xeeb thiab ua haujlwm tau zoo ntawm tinib hauv Suav cov neeg mob nrog ROS1-zoo tshaj NSCLC yuav pablorlatinibtau txais txiaj ntsig zoo rau cov neeg mob Suav sai li sai tau."

CStone Pharmaceuticals tau sau cov kev paub nplua nuj hauv kev tshawb fawb mob qog noj ntshav. Lub tuam txhab tsis ntev los no tau tshaj tawm qhov kev soj ntsuam zaum kawg rau nws cov qog tiv thaiv kab mob cov khoom qab zibizumab, qhia tias cov tshuaj muaj txiaj ntsig zoo rau cov neeg mob uas muaj theem 3 tsis yog mob qog noj ntshav tsawg ntawm lub ntsws (NSCLC), thiab qab zib qab zib tau dhau los ua lub ntiaj teb' thawj PD-1 lossis PD-L1 monoclonal antibody npog tag nrho cov pejxeem ntawm theem III thiab theem IV tsis-mob qog noj ntshav qog noj ntshav tsawg nyob rau tib lub sijhawm. Ib qho ntxiv, CStone Pharmaceuticals tau ua tiav kev lag luam ob yam tshuaj kho tau zoo hauv Suav teb. Lawv yog lub ntiaj teb thawj qhov tshuaj kho tau zoo Avatinib (lub npe lag luam: Taiji) rau GIST nrog PDGFRA exon 18 hloov pauv (suav nrog D842V hloov pauv). Hua), thiab thawj qhov kev xaiv RET inhibitor pratinib nyob hauv Suav teb (lub npe lag luam: Pugeta Hua), uas yog siv rau hauv ib cheeb tsam qib siab lossis metastatic tsis-mob qog noj ntshav ntawm lub ntsws uas tau txais platinum-muaj tshuaj kho mob rau RET fusion-positive Kev kho mob ntawm cov neeg laus cov neeg mob Txog CStone Pharmaceuticals, tsom mus rau qog tiv thaiv kab mob thiab kho kom raug, nrog txaus&"; mos txwv &";, 2021 yuav pib nyob rau hauv ib xyoos ntawm kev tawm tsam.

CStone Pharmaceuticals tau hais tias lub tuam txhab yuav txuas ntxiv txhawb kev koom tes ntau yam nrog Pfizer yav tom ntej kom coj kev kho mob qog nqaij hlav tshiab ntau dua rau cov neeg mob qog noj ntshav hauv Suav teb.

Cov khoom muaj peev xwm ntawm Pfizer' thoob ntiaj teb cov raj xa dej zoo:lorlatinib

CStone' kev sib sib zog nqus cog qoob loo hauv thaj chaw mob qog noj ntshav lub hauv paus los ntawm kev kuaj mob ntau thiab xav tau kev kho mob hauv daim teb no.

Xyoo tsis ntev los no, qhov tshwm sim ntawm mob qog noj ntshav hauv kuv lub tebchaws tau nce ntxiv. Cov ntaub ntawv mob qog noj ntshav thoob ntiaj teb zaum kawg hauv xyoo 2020 qhia tias yuav muaj txog 820,000 tus neeg mob qog noj ntshav tshiab hauv Suav teb xyoo 2020, thiab kwv yees li 710,000 tus neeg tuag yuav yog mob qog noj ntshav hauv lub ntsws.

Raws li tus neeg sawv cev tshiab thiab tshwj xeeb cov yam ntxwv sib txawv, ROS1 rov kho dua yog qhov tseem ceeb mob qog noj ntshav ntsig txog tus neeg tsav tsheb, uas muaj ntau dua rau cov hluas, tsis haus luam yeeb lossis haus luam yeeb nrog lub ntsws adenocarcinoma. Tam sim no hauv Suav teb, kev kho mob xaiv rau ROS1-zoo mob qog noj ntshav cov neeg mob tau txwv. Tsuas muaj ib lub hom phiaj tshuaj hauv khw uas tuaj yeem siv rau kev kho mob ntawm ROS1-cov neeg mob qog noj ntshav zoo, thiab cov neeg mob tuaj yeem txhim kho tshuaj tiv thaiv tom qab lub sijhawm kho.

Loratinib yog lub cim thib peb ALK/ROS1 tyrosine kinase inhibitor (TKI) nrog lub hauv nruab nrab lub paj hlwb nkag mus rau lub zog, uas cia siab tias yuav muab txoj kev kho tshiab rau cov neeg mob ROS1-zoo siab NSCLC.

Hauv qhov pov thawj-ntawm-lub tswvyim kev tshawb fawb ntawm ROS1-positive advanced NSCLC, loratinib kuj tau qhia ua ntej qhov ua tau zoo thiab muaj kev nyab xeeb zoo. Loratinib tau txhim kho lub hom phiaj cov lus teb (ORR) thiab intracranial ORR hauv cov neeg mob nrog ROS1-positive advanced NSCLC uas tau kho nrog tshuaj TKI lossis ua tsis tiav ROS1 inhibitor kho. Rau cov neeg mob uas muaj lub paj hlwb metastases zoo, loratinib tau ua tiav qhov kev tshem tawm ntau dua thiab lub sijhawm tshem tawm ntev.

Loratinib tsis ntev los no tau pom zoo los ntawm Asmeskas Khoom Noj thiab Tshuaj Yeeb Tshuaj (FDA) rau thawj-kab kev kho mob ntawm cov neeg laus uas muaj tus kab mob ALK-zoo metastatic non-small cell ntsws tau lees paub los ntawm FDA-pom zoo txoj kev sim. Hauv Suav teb, ntau qhov kev tshawb fawb soj ntsuam ntawm loratinib rau ALK-mob ntsws cancer tau ua tiav, thiab nws daim ntawv thov tshuaj tshiab rau ALK-positive advanced NSCLC tau xa hauv lub Peb Hlis 2021.

Dr. Jiang Ningjun tau hais tias: "Peb zoo siab heev uas tuaj yeem sib koom tsim loratinib nrog Pfizer. Loratinib yog lub cim tshiab ALK/ROS1 lub hom phiaj tshuaj hauv Pfizer lub thoob ntiaj teb cov raj xa dej, thiab CStone's R& D pipeline tau nthuav dav ntxiv. "

CStone Pharmaceuticals tau xaivlorlatinibntawm Pfizer' ntau qhov kev ua haujlwm zoo oncology, vim tias nws muaj peev xwm loj hauv kev kho mob. Pfizer muaj ntau yam tshuaj kho tau zoo rau kev hloov pauv noob caj noob ces hauv kev mob ntsws ntsws, thiab muaj kev nkag siab tob txog kev ua lag luam ntawm ALK thiab ROS1 lub hom phiaj. Raws li tus tswv ntawm thawj-tiam ALK/ROS1 tyrosine kinase inhibitor crizotinib, Pfizer tau sau cov kev paub nplua nuj hauv daim teb no, ob qho hauv kev tshawb fawb thiab kev txhim kho thiab kev lag luam.

& quot; Kuv ntseeg tias nrog CStone' kev muaj peev xwm txhim kho kev kho mob thiab Pfizer' tus thawj coj muaj peev xwm ua lag luam, nws yuav txuas ntxiv ua rau kev txhim kho kev kho mob thiab kev lag luam ntawm loratinib ROS1 lub hom phiaj,&] & quot; hais tias Dr. Jiang Ningjun.

& quot; Kev tshawb fawb tus kheej + qhia" yog CStone' tus qauv tsim kho tshiab tshwj xeeb txij li nws tau tsim. Tam sim no, 8 ntawm nws 14 kab khoom tau tsim los ntawm nws tus kheej thiab 6 tau qhia. Kev qhia cov khoom lag luam los ntawm sab nrauv muab CStone lub sijhawm los xaiv cov khoom lag luam zoo tshaj plaws thiab ua cov khoom lag luam ntawm lub ntiaj teb, thiab tsim kom muaj cov khoom sib txawv muaj zog sib txawv. CStone' muaj peev xwm txhim kho kev kho mob kom ntseeg tau sai sai ntawm cov khoom lag luam tuaj txawv teb chaws hauv Suav teb. Xyoo no, CStone Pharmaceuticals npaj kom ua tiav kev pom zoo ntawm 4 cov tshuaj tshiab hauv khw. Yav tom ntej, nws npaj yuav xa 1-2 daim ntawv thov tshuaj kho mob tshiab txhua xyoo.