Commun Biol: Cov protein tshwj xeeb hauv lub hlwb yuav pab tiv thaiv Alzheimer

Tsis ntev los no, nyob rau hauv tsab ntawv ceeb toom tshawb fawb luam tawm nyob rau hauv thoob ntiaj teb phau ntawv Xov Xwm Kev Sib Tham txog Biology, cov kws tshawb fawb los ntawm University of Alberta thiab lwm lub koom haum tau pom tias cov protein ntau tshaj plaws hu ua CD 33 tuaj yeem ua lub luag haujlwm hauv kev tswj cov qe ntshav dawb ntawm tus tib neeg lub hlwb. Lub luag haujlwm tseem ceeb, kev tshawb fawb ntsig txog yuav pab tsim kho cov kev kho mob tshiab tiv thaiv Alzheimer' s kab mob.

Cov duab muaj nuj nqi: CC0 Tus Txhab Nyiaj Rau Tsoom Fwv

Cov kev tshawb fawb nyob rau hauv tsab xov xwm no yog ua tiav raws li cov kev tshawb pom dhau los. Cov kws tshawb nrhiav dhau los pom tias CD 33 protein yuav yog qhov tseem ceeb ua rau txo qis kev muaj mob ntawm cov tib neeg uas muaj Alzheimer' s kab mob. Txawm li cas los xij, tsawg dua ntawm 10% ntawm cov tib neeg muaj Cov CD no 33. Cov kws tshawb nrhiav Matthew Macauley tau hais tias microglial cov hlwb hauv lub hlwb yog lub luag haujlwm tseem ceeb hauv kev txhim kho Alzheimer' s kab mob thiab tias lawv muaj ob sab (muaj kev phom sij lossis tiv thaiv).

Lub xub ntiag ntawm CD 33 ntawm microglia qhia tau tias, hauv kev tsim nyog, lub cev tiv thaiv kab mob tuaj yeem tiv thaiv lub cev' s lub hlwb los ntawm Alzheimer' s kab mob; yog tias cov kws tshawb fawb tuaj yeem tsom lub hom CD no ntau dua 33 cuam tshuam rau Microglia ua rau lawv zoo li microglia uas coj cov CD tsis tshua muaj tsawg 33, yog li nws xav tias yuav pab ua kom microglia tiv thaiv Alzheimer' s mob.

Cov kws tshawb nrhiav tau taw qhia tias cov txiaj ntsig ntawm txoj kev kawm no tau tsim lub hauv paus rau tom qab kev txhim kho ntawm kev sib raug zoo ntawm CD 33 thiab Alzheimer' s kab mob, thiab nws tseem xav tias yuav pab tsim kho cov tswv yim kho tshiab hloov pauv microglia teeb meem los ntawm kev hom phiaj CD 33 Cov kev phom sij rau lub cev. Microglia tuaj yeem tshem tawm cov leeg neurodegenerative plaques los ntawm cov txheej txheem hu ua phagocytosis, yog li cov tswv yim no tuaj yeem ua rau qeeb lossis thim rov qab rau ntawm Alzheimer' s kab mob. Raws li Alzheimer' s Koom Haum cov ntaub ntawv, 747, 000 Cov neeg Canadians tam sim no muaj Alzheimer' s kab mob lossis lwm hom dementia, uas cuam tshuam rau kev noj qab haus huv ntau dua ntawm { {8}} lab tus neeg thoob ntiaj teb. Cov kws tshawb nrhiav tom qab no tseem yuav tsim kho cov kev kho tshiab uas muaj txiaj ntsig tiv thaiv Alzheimer' s kab mob los ntawm kev tshawb nrhiav ntau dua. (los ntawm Bioon.com, sau hsppharma.com)

yuavtsum txuj lom ：

Bhattacherjee, A., Rodrigues, E., Jung, J. li al.Kev tsuj cov kab mob phagocytosis los ntawm tib neeg CD 33 tsis yog tshwj tseg nrog nas CD 33.Sib Biol2, 450 (2 019) doi: 10. 10 38 / s4 2 003-019-0698-6