Samuraciclib CAS 1805833-75-3

Product Description:

Khoom npe: Samuraciclib CAS 1805833-75-3

 

Synonyms:

(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,{6}}a]pyrimidin-5-yl)amino)methyl)piperidin -3-ol;

PPDA-001;

ICEC0942 (CT7001) Dawb puag.

 

Chemical & Physical Properties

Cov tsos mob: Cov hmoov hmoov

Kev Ntsuas: NLT98%

Qhov ceev: 1.30g / cm3

Cov khoom siv tshuaj lom neeg: Soluble hauv DMSO

 

Daim ntawv thov: Samuraciclib yog lub zog, xaiv, ATP-kev sib tw thiab qhov ncauj nquag CDK7 inhibitor, nrog IC50 ntawm 41 nM. Samuraciclib qhia 45-, 15-, 230- thiab 30-fold selectivity tshaj CDK1, CDK2 (IC50 ntawm 578 nM), CDK5 thiab CDK9, feem. Samuraciclib inhibits kev loj hlob ntawm cov kab mob qog nqaij hlav hauv lub mis nrog GI50 qhov tseem ceeb ntawm 0.2-0.3 µM. Samuraciclib muaj cov tshuaj tiv thaiv qog.

 

Peb kuj tuaj yeem muab tauSamuraciclib nruab nrab:

3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol 771510-25-9;

5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine 771510-32-8;

tert-butyl benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate 1092444-33-1;

(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,{6}}a]pyrimidin-5-yl)amino)methyl)piperidin -3-ol 1805833-75-3;

(3R,4R)-tert-Butyl4-(aminomethyl)-3-(methoxymethoxy)piperidine-1-carboxylate 1805790-20-8;

N-Boc-4-(hydroxymethyl)-1,2,3,6-tetrahydropyridine 203663-26-7.

 

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

 

 

Cov khoom raws li patent yog muab rau R & D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: samuraciclib cas 1805833-75-3, manufacturers, lwm tus neeg, Hoobkas, yuav, Tshuag

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