Hu rau:Errol Zhou (Mr.)
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Ntxiv:1002, Huanmao Tsev, No.105, Mengcheng Txoj kev, Hefei Lub zos, 230061 Tuam Tshoj
CAS Nr: 2101700-15-4
Cov roj formula: C22H21F4N5O3
Molecular Luj: 479.43
EINECS NO:864-730-9
MDL Nr.: MFCD34179491
Product Description:
Khoom npe: Pirtobrutinib CAS 2101700-15-4
Synonyms:
(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,{ {8}}trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide;
LOXO-305;
TIAB SA 3527727.
Chemical & Physical Properties
Cov tsos mob: Dawb mus rau cov hmoov dawb dawb
Kev ntsuam xyuas: NLT99%
Kub Point: 619.2 degree
Qhov ceev: 1.44 ± {2}}.1 g / cm3 (Predicted)
Solubility: DMSO: 50 mg / mL (104.29 mM; Xav tau ultrasonic)
Daim ntawv thov: Pirtobrutinib, tseem hu ua LOXO-305 thiab LY 3527727, yog Bruton's tyrosine kinase (BTK) inhibitor thiab antineoplastic agent. Pirtobrutinib tau pom tias muaj kev vam meej thawj zaug hauv pts nrog pretreated Richter transformation nrog rau cov neeg mob tsis zoo, nrog rau cov neeg mob uas tau txais kev kho mob ua ntej chemoimmunotherapy thiab covalent BTK inhibitors. Pirtobrutinib yog ib qho kev xaiv zoo heev thiab muaj zog uas tsis yog-covalent BTK inhibitor (BTKi) nrog rau qhov ncauj bioavailability siab thiab ib nrab-lub neej ntev, ua rau muaj zog BTK lub hom phiaj txawm tias nyob rau hauv qib siab malignancies nrog siab BTK protein turnover.
Pirtobrutinib, ib qho kev xaiv zoo heev thiab tsis yog-covalent tiam tom ntej BTK inhibitor, inhibits ntau BTK C481 hloov pauv hloov pauv. Pirtobrutinib ua rau regression ntawm BTK-dependent lymphoma hlav hauv nas xenograft qauv. Pirtobrutinib kuj tseem muaj ntau dua 300-fold xaiv rau BTK piv rau 370 lwm kinases kuaj thiab qhia tias tsis muaj qhov cuam tshuam tseem ceeb ntawm non-kinase off-targets ntawm 1 μM.
Peb kuj tuaj yeem muab Pirtobrutinib nruab nrab:
4-[[(5-fluoro-2-methoxy-benzoyl)amino]methyl]benzoic acid CAS 1571888-11-3;
N-[[4-(2,2-dicyano-1-methoxy-vinyl)phenyl]methyl]-5-fluoro-2-methoxy-benzamide CAS 2764851-04-7 };
[(1S)-2,2,2-tri-fluoro-1-methyl-ethyl]hydrazine CAS 2764851-02-5;
[(1S)-2,2,2-trifluoro-1-methylethyl]hydrazine hydrochloride CAS 2764851-03-6.
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Cim npe nrov: pirtobrutinib cas 2101700-15-4, manufacturers, lwm tus neeg, Hoobkas, yuav, Tshuag
