Ledipasvir CAS 1256388-51-8

Khoom Qhia:

Khoom Siv Lub Npe: Ledipasvir CAS TSIS TAU: 1256388-51-8

Txhais:

GS-5885;

Methyl N - [(2S) -1 - [(6S) -6- [5- [9,9-Difluoro-7- [2 - [(1S, 2S, 4R) -3 - [(2S) -2- (methoxycarbonylamino) -3-methylbutanoyl] -3-azabicyclo [2.2.1] heptan-2-yl] -3H-benzimidazol-5-yl] fluoren-2-yl] -1H-imidazol-2-yl] -5- azaspiro [2.4] heptan-5-yl] -3-methyl-1-oxobutan-2-yl] carbamate;

Tshuaj& Cov Khoom Uas Lub Cev:

Zog: cov hmoov dawb dawb dawb-dawb

Ntsuas: ≥99.0%

Qhov ceev: 1.4 g / cm3

Ledipasvir (yav dhau los GS-5885) yog yeeb tshuaj rau kev kho mob siab hom C uas tau tsim los ntawm Gilead Sciences. Tom qab ua tiav qhov kev kuaj mob Theem III, Lub Ob Hlis 10, 2014 Gilead tau thov rau Asmeskas pom zoo rau cov tshuaj leadipasvir / sofosbuvir txhaj tshuaj sib xyaw ua ke rau cov kabmob muaj kabmob 1 kab mob siab C. Tus kabmob leadipasvir / sofosbuvir ua ke yog tus neeg sawv cev tiv thaiv kev tiv thaiv kabmob uas cuam tshuam nrog HCV replication thiab tuaj yeem siv los kho cov neeg mob genotypes 1a lossis 1b yam tsis muaj PEG-interferon lossis ribavirin.

Ledipasvir yog ib qho inhibitor ntawm tus kab mob siab C tus kab mob NS5A protein.

Cov ntaub ntawv nthuav tawm ntawm Lub Rooj Sab Laj 20 ntawm Retroviruses thiab Cov Cuam Tshuam Cov Kab Mob hauv Lub Peb Hlis 2013 tau qhia tias muaj peb tus lej sib luag ntawm nucleotide analog inhibitor sofosbuvir, ledipasvir, thiab ribavirin tsim 12 lub lis piam tom qab-kho mob txhawb kev tiv thaiv kab mob (SVR12) ntawm 100% rau ob qho tib si kev kho mob-cov neeg tsis muaj zog thiab ua ntej tsis teb nrog HCV caj ces 1. Lub sofosbuvir / ledipasvir coformulation raug sim nrog thiab tsis muaj ribavirin. Thaum Lub Ob Hlis 2014 Gilead tau ua ntawv thov rau Tsoomfwv Meskas Khoom Noj thiab Tshuaj (FDA) pom zoo ntawm kev coj tshuaj lipipavir / sofosbuvir, tsis muaj tshuaj interferon thiab ribavirin.

Lub Kaum Hlis 10, 2014 FDA tau pom zoo rau kev sib xyaw ua ke khoom siv leadipasvir / sofosbuvir hu ua Harvoni.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov hu rau peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: cojipasvir cas 1256388-51-8, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

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