Cevimeline Hydrochloride Hemihydrates CAS 153504-70-2

Khoom Piav Qhia

Khoom npe: Cevimeline hydrochloride hemihydrates CAS 153504-70-2

Txhais:

Cevimeline hydrochloride hemihydrate;

cis-2-Methylspiro (1,3-oxathiolane-5,3') quinuclidine hydrochloride hydrate (2: 2: 1);

(+ / -) - cis-2-Methylspiro [1,3-oxathiolane-5,3' -quinuclidine] hydrochloride hemihydrate;

(+ / -) - cis-2-methylspiro [1,2-oxathiolane-5,3' -quinclidine] monohydrochloride;

Cevimeline HCl 1 / 2H2o;

(+ / -) - cis-2-methylspiro [1,3-oxathiolane-5,3' -quinuclidine] monohydrochloride;

cevimeline hydrochloride;

(+ / -) - cis-2-methylspiro [1,3-oxathiolane-5,3' -quinuclidine] monohydrochloride hemihydrate;

CeviMeline hydrochloride hemihydrates;

CevimelineHCl;

Tshuaj& Lub cev nqaij daim tawv

Zog: Cov hmoov dawb dawb

Ntsuas: ≥99.0%

Qhov ceev: 1.19g / cm3

Lub Ntsiab Kub: 308.5 ℃ ntawm 760 mmHg

Flash Point: 140.4 ℃

Cevimeline hydrochloride hemihydrate, tshiab tshuaj muscarinic receptor agonist, yog tus neeg sib tw muab tshuaj rau xerostomia hauv Sjogren' s syndrome. Tus nqi IC50: Phiaj: mAChRQhov tshuaj feem ntau. Cov cuab yeej ntawm cov tshuaj no ntawm lub plab zom mov, tso zis, thiab lub cev muaj zog thiab lwm yam nqaij tau tshawb xyuas hauv nas, nas, Guinea npua, luav, thiab dev. Hauv tshuaj vitro. ntawm SNI-2011 tseem raug soj ntsuam nrog cov nas thiab dev daim tawv nqaij microsomes. Tom qab lub qhov ncauj tswj hwm, ntshav plooj. ntawm SNI-2011 tau mus txog rau Cmax li ntawm 1 h hauv ob hom, qhia tias SNI-2011 tau nqus sai, thiab tom qab ntawd poob qis nrog t1 / 2 ntawm 0.4-1.1 h. Txoj kev nyab xeeb yog 50% thiab 30% hauv nas thiab dev, resp. Cov tshuaj loog loj hauv plasma yog ob qho tib si S- thiab N-oxidized metabolites hauv cov nas thiab tsuas yog N-oxidized metabolite hauv dev, qhia tias muaj ntau hom sib txawv yog obsd. hauv cov metabolism. ntawm SNI-2011. Poj niam txiv neej txawv kuj tseem dub. hauv cov khw muag tshuaj ntawm SNI-2011 hauv nas, tab sis tsis muaj hauv dev. Hauv kev tshawb fawb hauv vitro, tshuaj lom neeg. kev txwv tsis pub thiab pH-cov kev tshawb fawb siv qhia tias sulfoxidn. thiab N-oxidn. ntawm SNI-2011 tau raug sib kho los ntawm cytochrome P 450 (CYP) thiab flavin-contg. monooxygenase (FMO), resp., hauv ob hom. Hauv ntxiv, CYP2D thiab CYP3A tau ua lub luag haujlwm tseem ceeb rau sulfoxidn. hauv nas mob siab ua microsomes.

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Cim npe nrov: cevimeline hydrochloride hemihydrates cas 153504-70-2, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: IRAK Tus Neeg Tso Cai Kev Tso Npe 6 CAS 1042672-97-8
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