Apalutamide (ARN-509) CAS 956104-40-8

Khoom Qhia:

Khoom npe: Apalutamide (ARN-509) CAS TSIS TAU: 956104-40-8

Txhais:

4- [7- [6-cyano-5- (trifluoromethyl) pyridin-3-yl] -8-oxo-6-thioxo-5,7-diazaspiro [3.4] octan-5-yl] -2-fluoro-N -methylbenzamide;

Benzamide, 4- [7- [6-cyano-5- (trifluoromethyl) -3-pyridinyl] -8-oxo-6-thioxo-5,7-diazaspiro [3.4] oct-5-yl] -2-fluoro- N-methyl;

Tshuaj& Cov Khoom Uas Lub Cev:

Zog: Dawb kom dawb-dawb hmoov

Ntsuas: ≥99.0%

Qhov ceev: 1.6 g / cm3

Melting point: 190-192 ℃

Solubility DMSO ntawm 25 ° C: 18mg / ml

Solubility Dej ntawm 25 ° C: Insoluble

Solubility Ethanol ntawm 25 ° C: 5mg / ml

Apalutamide (INN) (kev loj hlob code npe ARN-509, kuj JNJ-56021927) yog non-steroidal antiandrogen uas tab tom tsim kho kev kho mob qog nqaij hlav prostate. Nws yog qhov zoo ib yam li enzalutamide ob qho tib si kev teeb tsa thiab pharmacologically, ua yeeb yam raws li xaiv kev sib tw ntawm cov androgen receptor (AR), tab sis qhia qee qhov zoo, suav nrog ntau dua potency thiab txo cov hlab hlwb nruab nrab permeation. Apalutamide khi tsis muaj zog mus rau GABAA receptor zoo ib yam li enzalutamide, tab sis vim nws qhov qis qis tshaj qhov nruab nrab, yuav muaj kev pheej hmoo qis ntawm qaug dab peg hauv kev sib piv.

Cov tshuaj tau tshawb pom tias muaj txiaj ntsig zoo thiab muaj kev tiv thaiv zoo hauv kev sim tshuaj mus txog thaum tam sim no, nrog rau cov kev mob tshwm sim feem ntau suav nrog kev qaug zog, xeev siab, mob plab, thiab zawv plab.

Tam sim no Apalutamide nyob rau theem III kev soj ntsuam kuaj mob rau mob castration-resistant prostate.

Tsis ntev los no, kev tau kis F876L hloov pauv ntawm AR tau txheeb pom nyob hauv qib siab prostate qog nqaij hlav tau raug pom los lees paub ob qho enzalutamide thiab apalutamide. Cov tshuaj antiandrogen tshiab, darolutamide (ODM-201), tsis cuam tshuam los ntawm qhov kev hloov pauv no, tsis tau pom tias muaj kev cuam tshuam los ntawm lwm qhov kev sim / paub zoo txog kev hloov AR; Apalutamide tej zaum yuav ua hauj lwm zoo nyob rau hauv ib tso tawm ntawm cov neeg mob qog nqaij hlav prostate nrog cov muaj peev xwm tiv taus abiraterone acetate.

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam hauv qab patent yog muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tau txiav txim siab nrog cov neeg yuav khoom.

Cim npe nrov: apalutamide (arn-509) cas 956104-40-8, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

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