7-Xylosyl-10-deacetyltaxol CAS 90332-63-1

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Khoom Siv Lub Npe: 7-Xylosyl-10-deacetyltaxol CAS 90332-63-1

Txhais:

Benzenepropanoic acid, β- (benzoylamino) -α-hydroxy-, (2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS) -12b- (acetyloxy) -12- (benzoyloxy) -2a, 3, 4,4a, 5,6,9,10,11,12,12a, 12b-dodecahydro-6,11-dihydroxy-4a, 8,13,13-t etramethyl-5-oxo-4- (β-D- xylopyranosyloxy) -7,11-methano-1H-cyclodeca [3,4] benz [1,2-b] oxet-9-yl ester, (αR, βS) -;

(2α, 3β, 5β, 7β, 10β, 13α) -4-Acetoxy-13 - {[(2R, 3S) -3- (benzoylamino) -2-hydroxy-3-phenylpropanoyl] oxygen} -1,10-dihydroxy -9-oxo-7- (β-D-xylopyranosyloxy) -5,20-epoxytax-11-en-2-yl benzoate;

(2α, 5β, 7β, 10β, 13α) -4-Acetoxy-13 - {[(2R, 3S) -3- (benzoylamino) -2-hydroxy-3-phenylpropanoyl] oxygen} -1,10-dihydroxy-9 -oxo-7- (β-D-xylopyranosyloxy) -5,20-epoxytax-11-en-2-yl benzoate;

Benzenepropanoic acid, β- (benzoylamino) -α-hydroxy-, (2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aS, 12bS) -12b- (acetyloxy) -12- (benzoyloxy) -2a, 3, 4,4a, 5,6,9,10,11,12,12a, 12b-dodecahydro-6,11-dihydroxy-4a, 8,13,13-t etramethyl-5-oxo-4- (β-D- xylopyranosyloxy) -7,11-methano-1H-cyclodeca [3,4] benz [1,2-b] oxet-9-yl ester, (αR, βS) -

10-Deacetyl-7-xylosyl paclitaxel;

Tshuaj & Lub Cev Lub Cev

Zog: cov hmoov dawb dawb

Assay: ≥99.0%,

Qhov ceev: 1.5 ± 0.1 g / cm3

Lub Ntsiab Kub: 1068.4 ± 65.0 ℃ ntawm 760 mmHg

Flash Point: 599.9 ± 34.3 ℃

PSA: 274.14000

LogP: 7.18

Vapor Siab: 0.0 ± 0.3 mmHg ntawm 25 ° C

Qhov ntsuas ntawm kwv yees: 1.660

Soluble hauv methanol, ethanol, DMSO thiab lwm cov organic solvents.

10-Deacetyl-7-xylosyl paclitaxel yog Paclitaxel derivative nrog cov tshuaj muaj txiaj ntsig zoo dua qub thiab muaj dej ntau dua solubility.IC50 tus nqi: Lub Hom Phiaj: Microtubule inhibitor10-Deacetyl-7-xylosyl paclitaxel vim ua rau muaj kev cuam tshuam rau cov xov tooj ntawm tes thiab ua kom muaj kev tiv thaiv zoo raws li ntsuas los ntawm kev ntws cytometry, DNA laddering , thiab lub tshuab xa hluav taws xob hauv tshuab hluav taws xob. Pro-apoptotic Bax thiab cov lus qhia tsis zoo rau cov protein tau txhim kho thiab tiv thaiv apoptotic Bcl-2 thiab Bcl-XL kev qhia tawm, uas ua rau muaj kev cuam tshuam ntawm cov mitochondrial membrane permeability thiab kom ua haujlwm ntawm caspase-9. Nyob rau hauv lem, caspase-9 qhib dej hauv qab caspases-3 thiab -6, tab sis tsis yog caspase-8. Qhov kev twv tawm tau raug ua haujlwm los ntawm caspase-3. Rov qab, kev kho mob nrog ib tus caspase-10-cov inhibitor tshwj xeeb tsis tuaj yeem tiv thaiv PC-3 hlwb los ntawm 7-xylosyl-10-deacetyl-paclitaxel-triggered apoptosis. Ntxiv mus, 7-xylosyl-10-deacetylpaclitaxel tsis muaj kev cuam tshuam cov lus qhia ntawm CD95 thiab NF-kappaB cov nqaijrog, qhia tias apoptosis tau ntxias los ntawm mitochondrial-pathway hauv PC-3 hlwb.

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Cim npe nrov: 7-xylosyl-10-deacetyltaxol cas 90332-63-1, tuam ntxhab, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: Allopurinol CAS 315-30-0
• Tom ntej: 10-DAT, Deacetyltaxol CAS 78432-77-6