(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) Methanol CAS 2169271-28-5

Product Description:

Lub npe khoom: (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol CAS {{ 7}}

 

Synonyms:

TAK438 impurity 1;

Vonoprasan impurity 37;

1-[(2-chloro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde;

 

Chemical & Physical Properties

Cov tsos mob: N / A

Kev Ntsuas: 99% +

Kub taw tes: 564.5 ± 6 0.0 degree

Ceev: 1.38 ± {2}}.1g/cm³

Pka: 13.89 ± 0.10

 

Daim ntawv thov

(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol yog ib qho nruab nrab ntawm Vonorazan. Vonorazan fumarate (TAK-438), ib qho poov tshuaj ion (K +) kev sib tw acid blocker (P-CAB), yog ib qho kev hloov pauv ntawm proton twj tso kua mis inhibitor. Tom qab nkag mus rau hauv tib neeg lub cev, cov khoom lag luam tshem tawm cov kua qaub ntawm lub plab los ntawm inhibiting kev khi ntawm K + thiab H+-K+ -ATPase (proton twj tso kua mis) nyob rau hauv cov kauj ruam kawg ntawm cov kua qaub secretion hauv parietal hlwb. Cov khoom no muaj zog thiab kav ntev inhibitory nyhuv ntawm gastric acid secretion.

Piv nrog rau cov tsoos proton twj tso kua mis inhibitor lansoprazole, Vonoprazan ua haujlwm los ntawm kev sib tw thiab thim rov qab inhibition ntawm K + hauv lub twj tso kua mis proton. Cov kws kho mob thiab cov tsiaj sim tau pom tias Vonoprasan ua sai dua PPI lossis H2 blockers, muaj zog ua rau pH nce ntxiv, tuaj yeem txo cov tsos mob ntawm plab zom mov sai, thiab rov ua haujlwm enzyme tom qab zom mov. Tsawg qhov tsis zoo tshwm sim, Vonorazan muaj lipophilicity siab thiab siab dissociation tas li, thiab tuaj yeem ua haujlwm zoo hauv acidic ib puag ncig yam tsis muaj kua qaub. Vonorazan inhibits lub twj tso kua mis proton yam tsis muaj kua qaub ua kom lub plab thiab nkag mus rau hauv lub plab hauv siab ntau, ua rau cov nyhuv inhibitory loj tshaj plaws ntawm thawj koob tshuaj thiab kav ntev li 24 teev. Vonorazan ruaj khov hauv cov kua qaub, thiab tuaj yeem nce pH nqi hauv plab sai, ua rau cov kua qaub inhibitory nyhuv.

 

 

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

 

 

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Cim npe nrov: (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1h-pyrrol-3-yl) methanol cas 2169271-28-5 , manufacturers, lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: 2, 3-Pyrazinedcarboxylic Acid CAS 89-01-0
• Tom ntej: Crisaborole CAS 906673-24-3